Ginkgo Biloba Extract Improves Coronary Blood Flow in Patients with Coronary Artery Disease

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Ginkgo Biloba Extract Improves Coronary Blood Flow in Patients with

Coronary Artery Disease

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Ginkgo biloba extract improves coronary blood flow in

patients with coronary artery disease: role of endothelium-dependent

vasodilation, " Wu Y, Li S, et al, Planta Med, 2007; 73(7): 624-8.

(Address: Department of Cardiology, Second Hospital of Hebei Medical

University, Shijiazhuang, P.R. China. E-mail: caswu@... ).

Summary: In a double-blinded, randomized, placebo-controlled study

involving 80 patients with coronary artery disease (CAD), treatment with

ginkgo biloba extract (GBE) was found to improve coronary blood flow.

Subjects were randomly assigned to either receive an injectable solution

of GBE (ton, an aqueous solution containing 17.5 mg GBE for

injection per 5 mL ampoule; extract standardized to 24% ginkgo flavone

glycosides, corresponding to 4.2 mg ginkgo flavone glycosides per 5 mL

ampoule), at a dose of 0.7 mg/minute, or a placebo, for a period of 120

minutes. After treatment with GBE, significant increases in left

anterior descending coronary artery (LAD) blood flow in maximal

diastolic peak velocity (MDPV), maximal systolic peak velocity (MSPV)

and diastolic time velocity integral (DTVI) were found, as compared to

after placebo. Furthermore, flow-mediated dilation increased by 69.75%

(from 3.95 to 6.55). The percentage changes in MDPV, MSPV, or DTVI of

LAD blood flow were fou nd to be linearly correlated with the percentage

change in brachial artery FMD following treatment with GBE. The authors

conclude, " …GBE treatment in patients with CAD had a beneficial effect

on coronary flow, at least partially through endothelium-dependent

vasodilation. "

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ne Holden, MS, RD

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