Lycopene Inhibits Disease Progression in Patients with Benign Prostatic Hyperplasia

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Lycopene Inhibits Disease Progression in Patients with Benign Prostatic

Hyperplasia

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Lycopene inhibits disease progression in patients with

benign prostate hyperplasia, " Schwarz S, Obermuller-Jevic UC, et al, J

Nutr, 2007; 138(1): 49-53. (Address: University of Hohenheim, Institute

of Biological Chemistry and Nutrition, 70593 Stuttgart, Germany; 5 BASF

Aktiengesellschaft, 67117 Limburgerhof, Germany. E-mail:

biesal@... ).

Summary: In a placebo-controlled pilot study involving 40 elderly male

patients with histologically-confirmed benign prostatic hyperplasia

(BPH) who were free from prostate cancer, supplementation with lycopene

(15 mg/d) for a period of 6 months was found to reduce prostate-specific

antigen (PSA) levels, while placebo had no such effect. In addition, no

enlargement of the prostate was found in the lycopene-supplemented

group, while the placebo group was found to have progression of prostate

enlargement, assessed via trans-rectal ultrasonography and digital

rectal examination. Plasma lycopene concentrations increased among the

men taking lycopene, while levels of other carotenoids were unaffected.

Men in both groups experienced improvements in symptoms of BPH, assessed

via the International Prostate Symptom Score questionnaire, with a

greater improvement found among subjects in the lycopene-supplemented

group. These results suggest that lycopene may inhibit the progression

of BPH. Considering that men with BPH are at a higher risk of developing

prostate cancer, these results also suggest that lycopene may have a

role to play in the prevention of prostate cancer. Additional research

is warranted.

--

ne Holden, MS, RD < fivestar@... >

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