Vitamin D may Reduce Risk of Postmenopausal Breast Cancer

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Vitamin D may Reduce Risk of Postmenopausal Breast Cancer

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Serum 25-hydroxyvitamin D and risk of postmenopausal breast

cancer - results of a large case-control study, " Abbas S, Linseisen J,

et al, Carcinogenesis, 2007 Oct 31; [Epub ahead of print]. (Address:

Division of Cancer Epidemiology, German Cancer Research Center,

Heidelberg, Germany).

Summary: In a population-based, case-control study involving 1,394

subjects with breast cancer and 1,365 controls (between the ages of 50

and 74), serum 25(OH)D concentration - a marker of vitamin D status -

was found to be significantly inversely associated with postmenopausal

breast cancer risk. Results of conditional logistic regression analysis

found that compared to subjects with the lowest serum 25(OH)D

concentrations (less than 30 nM), those in the higher categories of

25(OH)D levels had significantly reduced odds ratios for breast cancer

(ORs of 0.57 for 30-45 nM, 0.49 for 45-60 nM, 0.43 for 60-75 nM, and

0.31 for 75 nM or greater). Fractional polynomial analysis indicated a

non-linear association. A stronger association was found for women who

had never used menopausal hormone replacement therapy, compared to women

who had or currently were using HRT. These results suggest that in

postmenopausal women, vitamin D status may play a role in affecting the

risk of developing b reast cancer. Additional research would be needed

to assess the effects of supplementation with vitamin D on risk of

breast cancer in this population.

--

ne Holden, MS, RD

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