effects of daily alendronate, daily calcitonin and alendronate every other day on bone mineral density in osteoporotic men

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Aging Male. 2007 Dec;10(4):197-201.

The effects of daily alendronate, daily calcitonin and alendronate

every other day on bone mineral density in osteoporotic men.

Guven Z, Karadag-Saygi E, Unlu-Ozkan F, Akyuz G.

Department of Physical Medicine and Rehabilitation, Marmara

University School of Medicine, Istanbul, Turkey.

Objectives. Biphosphonates have been widely used in the treatment

of osteoporosis, but there is not enough data on their use in men. The

aim of this study is to investigate the effects of twelve months'

treatment with daily 10 mg alendronate, every other day 10 mg

alendronate and daily 200 IU calcitonin on bone mineral density (BMD) in

men with osteoporosis. Materials and methods. 46 men with osteoporosis

were randomly allocated to three groups: 15 patients in the first group

received daily 10 mg alendronate and calcium (1000 mg/day), 14 patients

in the second group used every other day 10 mg alendronate and calcium

and 17 patients in the third group were given intranasal salmon

calcitonin and calcium. At the baseline, sixth and twelfth months, BMD

was measured at lumbar spine (L(2-4)), femoral neck and Ward's triangle

zone by means of dual energy X-ray absorptiometry (LUNAR). Results. In

daily and every other day alendronate and calcitonin groups there was a

significant increase in BMD at lumbar spine (p = 0.004, p = 0.001, p =

0.04), but no difference at the femoral neck (p > 0.05) at the end of

twelve months. When the groups were compared with each other, no

significant differences in BMD levels at lumbar spine, femoral neck and

Ward's triangle were found (p > 0.05).

PMID: 18033629 [PubMed - in process]

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