A coffee with your doughnut could protect against Alzheimer's disease

[Guest guest]

Colleagues, the following is FYI and does not necessarily reflect my own

opinion. I have no further knowledge of the topic. If you do not wish to

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---------------------------------------------------------

Public release date: 2-Apr-2008

http://www.eurekalert.org/pub_releases/2008-04/bc-acw040108.php

Contact: Charlotte Webber

charlotte.webber@...

44-0

BioMed Central

A coffee with your doughnut could protect against Alzheimer's disease

A daily dose of caffeine blocks the disruptive effects of high

cholesterol that scientists have linked to Alzheimer's disease. A study

in the open access publication, Journal of Neuroinflammation revealed

that caffeine equivalent to just one cup of coffee a day could protect

the blood-brain barrier (BBB) from damage that occurred with a high-fat

diet.

The BBB protects the central nervous system from the rest of the body's

circulation, providing the brain with its own regulated

microenvironment. Previous studies have shown that high levels of

cholesterol break down the BBB which can then no longer protect the

central nervous system from the damage caused by blood borne

contamination. BBB leakage occurs in a variety of neurological disorders

such as Alzheimer's disease.

In this study, researchers from the University of North Dakota School of

Medicine and Health Sciences gave rabbits 3 mg caffeine each day – the

equivalent of a daily cup of coffee for an average-sized person. The

rabbits were fed a cholesterol-enriched diet during this time.

After 12 weeks a number of laboratory tests showed that the BBB was

significantly more intact in rabbits receiving a daily dose of caffeine.

“Caffeine appears to block several of the disruptive effects of

cholesterol that make the blood-brain barrier leaky,” says

Geiger, University of North Dakota School of Medicine and Health

Sciences. “High levels of cholesterol are a risk factor for Alzheimer's

disease, perhaps by compromising the protective nature of the

blood-brain barrier. For the first time we have shown that chronic

ingestion of caffeine protects the BBB from cholesterol-induced leakage.”

Caffeine appears to protect BBB breakdown by maintaining the expression

levels of tight junction proteins. These proteins bind the cells of the

BBB tightly to each other to stop unwanted molecules crossing into the

central nervous system.

The findings confirm and extend results from other studies showing that

caffeine intake protects against memory loss in aging and in Alzheimer’s

disease.

“Caffeine is a safe and readily available drug and its ability to

stabilise the blood-brain barrier means it could have an important part

to play in therapies against neurological disorders,” says Geiger.

###

Notes to Editors:

1. Caffeine blocks disruption of blood brain barrier in a rabbit model

of Alzheimer's disease Xuesong Chen, W. Gawryluk, F.

Wagener, Othman Ghribi and D. Geiger Journal of

Neuroinflammation (in press)

During embargo, article available here:

http://www.jneuroinflammation.com/imedia/9007199481777929_article.pdf?random=997\

881

After the embargo, article available at journal website:

http://www.jneuroinflammation.com/

Please name the journal in any story you write. If you are writing for

the web, please link to the article. All articles are available free of

charge, according to BioMed Central’s open access policy.

Article citation and URL available on request at press@...

on the day of publication

2. Journal of Neuroinflammation is an Open Access, peer-reviewed online

journal that focuses on innate immunological responses of the central

nervous system, involving microglia, astrocytes, cytokines, chemokines,

and related molecular processes.

3. BioMed Central (http://www.biomedcentral.com/) is an independent

online publishing house committed to providing immediate access without

charge to the peer-reviewed biological and medical research it

publishes. This commitment is based on the view that open access to

research is essential to the rapid and efficient communication of science.

--

ne Holden, MS, RD

" Ask the Parkinson Dietitian " http://www.parkinson.org/

" Eat well, stay well with Parkinson's disease "

" Parkinson's disease: Guidelines for Medical Nutrition Therapy "

http://www.nutritionucanlivewith.com/

[Guest guest]

Is the 10:00 news, or are we professials, This is crazy. Are we

really going to talk about, make recommendations for people based on

what one study stays. PLEASE lets be real. This is the type of junk

that has people coming in with habits that they believe are helping

them. " I read that....I so I eat/drink it every day " Can we stop w/

the JUNK!!

>

> Colleagues, the following is FYI and does not necessarily reflect

my own

> opinion. I have no further knowledge of the topic. If you do not

wish to

> receive these posts, set your email filter to filter out any

messages

> coming from @nutritionucanlivewith.com and the program will

remove

> anything coming from me.

> ---------------------------------------------------------

>

> Public release date: 2-Apr-2008

> http://www.eurekalert.org/pub_releases/2008-04/bc-acw040108.php

>

> Contact: Charlotte Webber

> charlotte.webber@...

> 44-0

> BioMed Central

>

> A coffee with your doughnut could protect against Alzheimer's

disease

>

> A daily dose of caffeine blocks the disruptive effects of high

> cholesterol that scientists have linked to Alzheimer's disease. A

study

> in the open access publication, Journal of Neuroinflammation

revealed

> that caffeine equivalent to just one cup of coffee a day could

protect

> the blood-brain barrier (BBB) from damage that occurred with a high-

fat

> diet.

>

> The BBB protects the central nervous system from the rest of the

body's

> circulation, providing the brain with its own regulated

> microenvironment. Previous studies have shown that high levels of

> cholesterol break down the BBB which can then no longer protect the

> central nervous system from the damage caused by blood borne

> contamination. BBB leakage occurs in a variety of neurological

disorders

> such as Alzheimer's disease.

>

> In this study, researchers from the University of North Dakota

School of

> Medicine and Health Sciences gave rabbits 3 mg caffeine each day –

the

> equivalent of a daily cup of coffee for an average-sized person.

The

> rabbits were fed a cholesterol-enriched diet during this time.

>

> After 12 weeks a number of laboratory tests showed that the BBB was

> significantly more intact in rabbits receiving a daily dose of

caffeine.

>

> " Caffeine appears to block several of the disruptive effects of

> cholesterol that make the blood-brain barrier leaky, " says

> Geiger, University of North Dakota School of Medicine and Health

> Sciences. " High levels of cholesterol are a risk factor for

Alzheimer's

> disease, perhaps by compromising the protective nature of the

> blood-brain barrier. For the first time we have shown that chronic

> ingestion of caffeine protects the BBB from cholesterol-induced

leakage. "

>

> Caffeine appears to protect BBB breakdown by maintaining the

expression

> levels of tight junction proteins. These proteins bind the cells of

the

> BBB tightly to each other to stop unwanted molecules crossing into

the

> central nervous system.

>

> The findings confirm and extend results from other studies showing

that

> caffeine intake protects against memory loss in aging and in

Alzheimer's

> disease.

>

> " Caffeine is a safe and readily available drug and its ability to

> stabilise the blood-brain barrier means it could have an important

part

> to play in therapies against neurological disorders, " says Geiger.

>

> ###

>

> Notes to Editors:

>

> 1. Caffeine blocks disruption of blood brain barrier in a rabbit

model

> of Alzheimer's disease Xuesong Chen, W. Gawryluk, F.

> Wagener, Othman Ghribi and D. Geiger Journal of

> Neuroinflammation (in press)

>

> During embargo, article available here:

>

http://www.jneuroinflammation.com/imedia/9007199481777929_article.pdf?

random=997881

>

> After the embargo, article available at journal website:

> http://www.jneuroinflammation.com/

>

> Please name the journal in any story you write. If you are writing

for

> the web, please link to the article. All articles are available

free of

> charge, according to BioMed Central's open access policy.

>

> Article citation and URL available on request at press@...

> on the day of publication

>

> 2. Journal of Neuroinflammation is an Open Access, peer-reviewed

online

> journal that focuses on innate immunological responses of the

central

> nervous system, involving microglia, astrocytes, cytokines,

chemokines,

> and related molecular processes.

>

> 3. BioMed Central (http://www.biomedcentral.com/) is an independent

> online publishing house committed to providing immediate access

without

> charge to the peer-reviewed biological and medical research it

> publishes. This commitment is based on the view that open access to

> research is essential to the rapid and efficient communication of

science.

> --

> ne Holden, MS, RD

> " Ask the Parkinson Dietitian " http://www.parkinson.org/

> " Eat well, stay well with Parkinson's disease "

> " Parkinson's disease: Guidelines for Medical Nutrition Therapy "

> http://www.nutritionucanlivewith.com/

>