Polymorphisms in the MBL gene are not associated with erosions in RA or inflammatory polyarthritis

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J Rheumatol. 2004 Mar;31(3):442-7.

Polymorphisms in the mannose binding lectin (MBL) gene are not

associated with radiographic erosions in rheumatoid or inflammatory

polyarthritis.

Barton A, Platt H, Salway F, Symmons D, Lunt M, Worthington J, Silman A.

Arthritis and Rheumatism Campaign Epidemiology Unit, University of

Manchester, Manchester, UK. ABarton@fs 1.ser.man.ac.uk

OBJECTIVE: To investigate the association between the mannose binding

lectin gene (MBL) promoter and structural single nucleotide

polymorphisms (SNP) with development of erosions in a primary care

inception cohort of patients with inflammatory polyarthritis (IP).

METHODS: DNA was available from 438 patients with IP and radiographic

data were available for all patients at 5 years. Four SNP [MBL-550*C/G

(H/L), MBL-221*G/C (Y/X), MBL codon 52*C/T, and MBL codon 54*G/A]

mapping to the MBL gene were genotyped using primer extension

techniques. Allele frequencies were compared between IP cases with

erosions by 5 years and those without. RESULTS: None of the SNP were

associated with erosive outcomes by 5 years. Furthermore there was no

association with Larsen score by 1 or 5 years or with the change in

Larsen score between 1 and 5 years. Similarly, the genotype combinations

known to encode for low MBL protein production were not associated with

erosive outcome in the IP cohort as a whole or in those with rheumatoid

arthritis (RA) by 5 years.

CONCLUSION: Polymorphism within the MBL gene is not associated with

presence or extent of erosions by 5 years in patients with RA or IP.

PMID: 14994386

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