Sensitivity and specificity for primary Sjogren's syndrome of IgA and IgG anti-alpha-fodrin antibodies

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J Rheumatol. 2004 Mar;31(3):504-7.

Sensitivity and specificity for primary Sjogren's syndrome of IgA and

IgG anti-alpha-fodrin antibodies detected by ELISA.

Ruffatti A, Ostuni P, Grypiotis P, Botsios C, Tonello M, Grava C, Favaro

M, Todesco S.

Department of Medical and Surgical Sciences, University of Padova,

Padova, Italy. amelia.ruffatti@...

OBJECTIVE: To investigate the sensitivity and specificity of

anti-alpha-fodrin antibodies in patients with primary Sjogren's syndrome

(pSS). METHODS: IgA and IgG anti-alpha-fodrin antibodies were measured

in the sera of 80 patients with pSS, 60 blood donors matched for age and

sex, 50 patients with systemic lupus erythematosus (SLE), 30 with

rheumatoid arthritis (RA), 20 with systemic sclerosis (SSc), and 10 with

polymyositis or dermatomyositis (PM/DM) by an ELISA method employing

recombinant human alpha-fodrin as antigen. RESULTS: The sensitivity of

IgA and IgG anti-alpha-fodrin antibodies for pSS was 32.50% and 21.25%,

respectively. When the prevalence of these antibodies in patients with

SLE, RA, SSc, and PM/DM was evaluated, we observed specificity of these

antibodies of 68.18% and 79.09%, respectively. The sensitivity and

specificity for pSS of the combined determination of IgA and IgG

anti-alpha-fodrin antibodies were 40% and 58.18%, respectively.

CONCLUSION: The prevalences of IgA and IgG anti-alpha-fodrin antibodies

in our patients with pSS and other chronic autoimmune diseases have

induced us to doubt their use as diagnostic markers of pSS.

PMID: 14994395

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