Autoimmune thyroiditis and anti-thyroid antibodies in primary Sjogren's syndrome: a case-control study

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Ann Rheum Dis. 2004 May;63(5):575-7.

Autoimmune thyroiditis and anti-thyroid antibodies in primary Sjogren's

syndrome: a case-control study.

Tunc R, Gonen MS, Acbay O, Hamuryudan V, Yazici H.

Department of Internal Medicine, Division of Rheumatology, Meram School

of Medicine, Selcuk Universitesi, Konya, Turkey. trecep@...

OBJECTIVE: To determine the frequency of antithyroid antibodies and the

presence of autoimmune thyroiditis among patients with primary Sjogren's

syndrome. DESIGN: A case-control study. METHODS: 53 consecutive patients

with primary Sjogren's syndrome, 30 with rheumatoid arthritis, 12 with

secondary Sjogren's syndrome associated with rheumatoid arthritis, 17

with autoimmune thyroiditis, and 53 apparently healthy controls were

studied for anti-TG and anti-TPO antibodies as well as serum thyroid

hormones and TSH levels. RESULTS: The overall frequencies of thyroid

antibodies were 6/53 (11%) in primary Sjogren's syndrome, 2/30 (7%) in

rheumatoid arthritis, 2/12 (17%) in secondary Sjogren's syndrome, 4/53

(8%) in healthy controls, and 16/17 (94%) in autoimmune thyroiditis.

There was no difference in the frequency of the thyroid antibodies among

the groups if patients with autoimmune thyroiditis were excluded (p =

0.415 for anti-TPO; p = 0.275 for anti-TG; p = 0.696 for either anti-TG

and/or anti-TPO). Only two patients with primary Sjogren's syndrome had

clinical hypothyroidism associated with autoimmune thyroiditis.

CONCLUSIONS: In this Turkish population, no association between primary

Sjogren's syndrome and autoimmune thyroiditis was found.

PMID: 15082490

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