Vitamin B12 Supplementation May Reduce Delirium in Dementia Patients with Vitamin B12 Deficiency

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Vitamin B12 Supplementation May Reduce Delirium in Dementia Patients

with Vitamin B12 Deficiency

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Vitamin B(12) supplementation did not improve cognition but

reduced delirium in demented patients with vitamin B(12) deficiency, "

Kwok T, Lee J, et al, Arch Gerontol Geriatr, 2008; 46(3): 273-82.

(Address: Department of Medicine and Therapeutics, Prince of Wales

Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

E-mail: tkwok@... ).

Summary: In a study involving 30 consecutive mild to moderate dementia

patients with vitamin B12 deficiency, results indicate that

supplementation with vitamin B12 may reduce delirium associated with

dementia. The patients received 3 intramuscular injection of

methylcobalamin (1 mg) in the first week; oral supplementation with

methylcobalamin (1 tablet 3 times a day) for 16 weeks; and 1

intramuscular injection of cyanocobalamin (1 mg) once a month, for 6

months. At intervention end a significant decrease in Delirium Rating

Scale scores were observed compared to baseline. However, no significant

changes in cognitive function and behavioral symptoms were observed

between baseline and study end. Thus, the authors of this study

conclude, " Cognitive function of mild to moderately demented older

people with vitamin B(12) deficiency did not significantly change with

vitamin B(12) supplementation over a 10-month period. The

supplementation red uced delirium associated with dementia. "

--

ne Holden, MS, RD

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