Vitamin B12 deficiency neurological syndromes: correlation of clinical, MRI and cognitive evoked potential

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Vitamin B12 Deficiency and Neurological Syndromes

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Vitamin B12 deficiency neurological syndromes: correlation

of clinical, MRI and cognitive evoked potential, " Kalita J, Misra UK, et

al, J Neurol, 2008; 255(3): 353-9. (Address: Dept. of Neurology, Sanjay

Gandhi Post Graduate Institute of Medical Sciences (PGIMS), Rae Bareily

Road, Lucknow, 226014, India. E-mail: jayanteek@... ).

Summary: In a study involving 36 patients between the ages of 16 and 80

years of age (32 patients being over the age of 40 years) with low serum

B12 or megaloblastic bone marrow or both, a high incidence of cognitive

impairment and P3 abnormalities were found in patients which

significantly improved with vitamin B12 treatment. Of the subjects, 9

had myeloneurocognitive syndrome, 10 had myeloneuropathy, 8 had

myelocognitive syndrome, 8 had myelopathy, and 1 had cognitive syndrome.

An abnormal Mini Mental State Examination (MMSE) score was found in 17

of the patients, unrecordable P3 was found in 7 patients, P3 latency was

prolonged in 8 out of 33 patients, and multiple white matter

hyperintensity in T2 and 3 and cortical atrophy in 1 was found via

cranial MRI in 14 of the patients. Results found that scores on the MMSE

were abnormal in 47% of the subjects and P3 was abnormal in 45.5% of

subjects with vitamin B12 deficiency neurological syndromes. Treatment

with vita min B12 was found to improve the conditions. The authors

conclude, " There is high incidence of reversible cognitive impairment

and P3 abnormalities in B12 deficiency neurological syndromes. "

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