Vitamin B6 Supplementation May Be Necessary to Eliminate Vitamin B6 Deficiency

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Vitamin B6 Supplementation May Be Necessary to Eliminate Vitamin B6

Deficiency

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Plasma pyridoxal 5'-phosphate in the US population: the

National Health and Nutrition Examination Survey, 2003-2004, " MS,

Picciano MF, et al, Am J Clin Nutr, 2008; 87(5): 1446-54. (Address: Jean

Mayer US Department of Agriculture Human Nutrition Research Center on

Aging at Tufts University, Boston, MA 02111, USA. E-mail:

martha.morris@... ).

Summary: In a study investigating the vitamin B6 status of the U.S.

population, levels of plasma pyrixodal 5'-phosphate (PLP) - an indicator

of vitamin B6 adequacy - decreased with age in men who did not take

vitamin B6 supplements, were low in women of childbearing age regardless

of supplement use, and were < 20 nmol/L in women using oral

contraceptives. Subjects from all subgroups consuming between 2 and 2.9

mg/d vitamin B6 had significantly greater than 3% prevalence of low PLP.

Smokers, the elderly, non-Hispanic blacks and current and former oral

contraceptive users consuming between 3 to 4.9 mg/d vitamin B6 had

significantly greater than 3% prevalence of low PLP as well. In most

subgroups, consuming between 3 to 4.9 mg/d vitamin B6 offered

significant protection against low PLP, compared to consuming < 2 mg/d.

Consuming between 3 to 4.9 mg/d vitamin B6 also protected the elderly

from hyperhomocysteinemia. The authors conclude, " Vitamin B-6 intakes

of 3 to 4.9 mg/d appear consistent with the definition of a Recommended

Dietary Allowance for most Americans. However, at that intake level,

substantial proportions of some population subgroups may not meet

accepted criteria for adequate vitamin B-6 status. "

--

ne Holden, MS, RD

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