Vit. D--Breast CA, hip fracture

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Prevalence of Vitamin D Insufficiency in Breast Cancer Survivors

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Vitamin D insufficiency in a multiethnic cohort of breast

cancer survivors, " Neuhouser ML, Sorensen B, et al, Am J Clin Nutr,

2008; 88(1): 133-9. (Address: ML Neuhouser, Cancer Prevention Program,

Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North,

M4-B402, PO Box 19024, Seattle, WA 98109-1024, USA. E-mail:

mneuhous@... ).

Summary: In a cross-sectional study involving 790 breast cancer

survivors, the prevalence of insufficient vitamin D levels was high

(76%). The authors point out that vitamin D has an influence on pathways

that relate to carcinogenesis. After adjusting for various potential

confounders, stage of disease was found to independently predict serum

25(OH)D level. The mean serum 25(OH)D for the whole group was 24.8

ng/mL. For African-Americans, the mean serum 25(OH)D was 18.1 ng/mL, and

for Hispanics, the mean serum 25(OH)D was 22.1 ng/mL. Lower serum

25(OH)D levels were also found in women with localized or regional

breast cancer, as compared to women with in situ disease. These results

point to the prevalence of insufficient vitamin D status in survivors of

breast cancer. The authors conclude, " Clinicians might consider

monitoring vitamin D status in breast cancer patients, together with

appropriate treatments, if nece ssary. "

Low Vitamin D Status Linked to Hip Fracture

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Serum 25-hydroxyvitamin D concentrations and risk for hip

fractures, " Cauley JA, Lacroix AZ, et al, Ann Intern Med, 2008; 149(4):

242-50. (Address: University of Pittsburgh, Department of Epidemiology,

130 DeSoto Street, Crabtree A524, Pittsburgh, PA 15261, USA. E-mail:

jcauley@... ).

Summary: In a nested, case-control study involving 400 patients with

incident hip fracture and 400 controls who were followed for an average

of 7 years, serum 25(OH)D levels were lower among cases (55.95 nmol/L)

than controls (59.60 nmol/L). Moreover, lower serum 25(OH)D

concentrations increased the risk of hip fracture. Each 25-nmol/L

decrease was associated with a 1.33 adjusted odds ratio of hip fracture.

Women with the lowest concentrations of 25(OH)D (47.5 nmol/L or lower)

had a significantly higher risk of fracture compared to those with the

highest concentrations (70.7 nmol/L or higher), with an adjusted odds

ratio of 1.71. These results suggest that insufficient vitamin D status

may increase the risk of hip fractures.

--

ne Holden, MS, RD

" Ask the Parkinson Dietitian " http://www.parkinson.org/

" Eat well, stay well with Parkinson's disease "

" Parkinson's disease: Guidelines for Medical Nutrition Therapy "

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