Prior medical conditions and medication use and risk of non-Hodgkin lymphoma in Connecticut US women

July 28, 2004

Cancer Causes Control. 2004 May;15(4):419-28.

Prior medical conditions and medication use and risk of non-Hodgkin

lymphoma in Connecticut United States women.

Zhang Y, Holford TR, Leaderer B, Zahm SH, Boyle P, Morton LM, Zhang B,

Zou K, Flynn S, Tallini G, Owens PH, Zheng T.

Department of Epidemiology and Public Health, Yale University School of

Medicine, New Haven, CT 06520, USA.

OBJECTIVE: To further investigate the role of prior medical conditions

and medication use in the etiology of non-Hodgkin lymphoma (NHL), we

analyzed the data from a population-based case-control study of NHL in

Connecticut women. METHODS: A total of 601 histologically confirmed

incident cases of NHL and 717 population-based controls were included in

this study. In-person interviews were administered using standardized,

structured questionnaires to collect information on medical conditions

and medication use. RESULTS: An increased risk was found among women who

had a history of autoimmune disorders (such as rheumatoid arthritis,

lupus erythematosus, Sjogren's syndrome, and multiple sclerosis),

anemia, eczema, or psoriasis. An increased risk was also observed among

women who had used steroidal anti-inflammatory drugs and tranquilizers.

A reduced risk was found for women who had scarlet fever or who had used

estrogen replacement therapy, aspirin, medications for non-insulin

dependent diabetes, HMG-CoA reductase inhibitors, or beta-adrenergic

blocking agents. Risk associated with past medical history appeared to

vary based on NHL subtypes, but the results were based on small number

of exposed subjects.

CONCLUSION: A relationship between certain prior medical conditions and

medication use and risk of NHL was observed in this study. Further

studies are warranted to confirm our findings.

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Mayo Clinic in Rochester

s Hopkins Medicine

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