Re: Enbrel - facial rash, ANA positivity

[Guest guest]

Thank you ,

These sites helped alot. It makes me feel more at ease. I knew you could

find something for me to read I will read more. It is very helpful.

Thank you

Renate

[ ] Enbrel - facial rash, ANA positivity

> Bulletin on the Rheumatic Diseases

> 2003 - 2004

> " Safety of New Biologic Therapies in Rheumatoid Arthritis "

> Volume 52, Number 8

>

>

> " Drug-induced Lupus. ANA positivity is commonly found in 30% to 40% of

> RA patients, regardless of DMARD use. In controlled clinical trials, the

> incidence of new ANA positivity ranged from 26% to 49% with infliximab

> to 11% with etanercept and 12.9% with adalimumab-treated patients

> (3,4,5,6). However, ANA positivity has no pathogenic significance in

> these patients. Possibly of greater concern is the occurrence of native

> (or double-stranded) DNA antibodies found in a subset of infliximab (8%

> to 15%), etanercept (3% to 15%), and adalimumab (5.6%) treated patients.

> Nevertheless, the incidence of TNF inhibitor-related drug-induced lupus

> is very rare. Among 1,897 infliximab-treated patients, there are only 4

> reports of a lupus-like disease (0.2%) (26).

>

> Several reports of lupus-like disease have appeared in the postmarketing

> era (26,27,28,29,30). Most patients appear to have mild to moderate

> symptoms that include fever, arthritis, serositis, rashes (ie, facial,

> discoid, or subacute cutaneous lupus or vasculitic rashes), and

> autoantibodies. While most have shown positive serologies for

> antinuclear antibodies and anti-dsDNA antibodies, other antibodies

> against Sm, RNP, histone, and cardiolipin and hypocomplementemia have

> been observed less frequently. There have been no clinical reports of

> the nephritis, cerebritis, or antiphospholipid syndrome. All cases

> resolved when the TNF inhibitor was withdrawn. Routine monitoring for

> ANA or DNA autoantibodies in patients receiving anti-TNF therapy is not

> advised but may be indicated in patients who exhibit either an

> unexpected flare of their arthritis, fever, serositis, or rash. "

>

> http://www.arthritis.org/research/Bulletin/Vol52No8/Safety_Concerns.asp

>

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> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>

>

>

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>