Antibodies to tTg and SCA in ankylosing spondylitis and psoriatic arthritis

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J Rheumatol. 2004 May;31(5):920-4.

Antibodies to tissue transglutaminase and Saccharomyces cerevisiae in

ankylosing spondylitis and psoriatic arthritis.

Riente L, Chimenti D, Pratesi F, Sedie AD, Tommasi S, Tommasi C,

Bombardieri S, Migliorini P.

Rheumatology and Immunology Units, Department of Internal Medicine,

University of Pisa, Pisa, Italy. lriente@...

OBJECTIVE: Subclinical gut inflammation has been described in patients

with ankylosing spondylitis (AS) or psoriatic arthritis (PsA). Joint

involvement has also been reported related to celiac disease. We

investigated IgA antibodies to bovine tissue tranglutaminase (tTg) and

IgA and IgG antibodies to human tTg and to Saccharomyces cerevisiae

(ASCA) in patients with AS and PsA. METHODS: We evaluated the frequency

of IgA antibodies to bovine tTg, and of IgA and IgG antibodies to human

tTg and to ASCA in 43 patients with AS and 75 with PsA. As control

groups we considered 79 patients with rheumatoid arthritis (RA) and 78

healthy blood donors. RESULTS: We detected antibodies as follows: IgA

antibodies to bovine tTg in 1/43 patients with AS, 3/75 with PsA, 1/79

with RA, and in 9/78 healthy controls; IgA antibodies to human tTg in

1/43 patients with AS, 1/75 with PsA, 1/79 with RA, and in 3/78 healthy

controls; IgG antibodies to human tTg in 1/43 patients with AS, 4/75

with PsA, 5/79 with RA, and in 7/78 healthy controls. IgA ASCA were

confirmed in 10/43 patients with AS, 7/75 with PsA, 14/79 with RA, and

in 7/78 healthy controls; IgG ASCA were present in 5/43 patients with

AS, 4/75 with PsA, 8/79 with RA, and in 8/78 healthy controls. No

statistically significant difference was observed in the prevalence of

IgA or IgG antibodies to bovine and human tTg and in the frequency and

in mean level of IgA or IgG ASCA between the studied groups or between

each group and healthy controls.

CONCLUSION: Our data fail to show an increased prevalence of

autoantibodies associated with celiac and Crohn's disease in patients

with AS and PsA.

PMID: 15124251

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