NEWS - Mice study opens door to psoriasis treatment

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Mice study opens door to psoriasis treatment

Last Updated: 2004-12-13 10:19:12 -0400 (Reuters Health)

WASHINGTON (Reuters) - Researchers said on Sunday they may have

discovered what causes psoriasis, a common and irritating skin ailment,

and said their findings may open the way to an effective treatment.

They found that it takes a combination of a protein called STAT3 and an

active immune system to cause psoriasis, which experts estimate affects

as much as 2 percent of the population.

Their finding suggests that psoriasis may start with an

over-enthusiastic attempt by the body to heal wounds.

And the researchers at The University of Texas M. D. Cancer

Center made a skin cream that blocked the process that leads to

psoriasis in mice.

" We may have found an entirely new treatment option for psoriasis, " said

M.D. 's DiGiovanni, who led the study.

" We have developed a mouse model that exhibits all the major features of

human psoriatic lesions and shown we can reverse those steps. "

Psoriasis is a chronic condition in which patches of skin become

inflamed and become itchy, red and flaky. There is no good treatment,

although symptoms can be alleviated.

The disease involves skin cells called keratinocytes that grow too fast

and too abundantly.

" There has been an ongoing controversy about whether the primary defect

in psoriasis is in the immune system or in the keratinocytes, "

DiGiovanni said in a statement.

" We may have found the link -- the change in keratinocytes that

cooperates with the immune system cells necessary for development of

human psoriasis. "

Writing in the journal Nature Medicine, the researchers said they looked

at STAT3, a protein involved in wound healing and the development of

skin cancer.

Activated STAT3 is essential for wound healing. When the healing process

is complete, normal STAT3 returns to its inactive form. But when it

fails to turn off, the wound healing process continues and skin cells

proliferate.

DiGiovanni's team first looked for activated STAT3 in the skin of

psoriasis patients and found high levels of activated STAT3 in psoriasis

lesions in 19 of 21 of them.

They bred a mouse in which STAT3 is always turned on in the keratinocyte

skin cells, and these mice always developed psoriasis.

The researchers then developed a solution containing a small piece of

DNA called an oligonucleotide, which was designed to prevent STAT3 from

activating genes.

It helped clear up the lesions in the mice.

" This study opens the door to a whole new kind of therapy for

psoriasis, " said DiGiovanni.

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org