RESEARCH - Osteonecrosis in patients with SLE develops very early after starting high dose corticosteroid treatment

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Ann Rheum Dis 2001;60:1145-1148 ( December )

Concise report

Osteonecrosis in patients with systemic lupus erythematosus develops

very early after starting high dose corticosteroid treatment

K Oinumaa, Y Haradaa, Y Nawatab, K Takabayashib, I Abea, K Kamikawaa, H

Moriyaa

a Department of Orthopaedic Surgery, Chiba University School of

Medicine, Japan, b Second Department of Internal Medicine, Chiba

University School of Medicine, Japan

Correspondence to: Dr K Oinuma, Department of Orthopaedic Surgery,

Kamitsuga-sogo Hospital, 1-1033, Shimoda-machi, Kanuma City, 322-8550,

Japan info@...

OBJECTIVES To investigate the actual time of onset of osteonecrosis (ON)

after high dose corticosteroid treatment in systemic lupus erythematosus

(SLE).

METHODS 72 patients with active SLE, who received high dose

corticosteroid for the first time, for the development of ON at hips and

knees were monitored by magnetic resonance imaging for at least 12

months.

RESULTS ON lesions were detected in 32/72 patients (44%) between one and

five months (3.1 months on average) after starting high dose

corticosteroid treatment. No osteonecrotic lesion was newly detected

from the sixth month of treatment until the end of the follow up period.

CONCLUSION The findings suggested that the actual time of onset of ON in

SLE is within the first month of high dose corticosteroid treatment.

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