RESEARCH - Dyslipoproteinemia in patients with active rheumatoid arthritis

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J Rheumatol. 2004 Sep;31(9):1746-53.

Dyslipoproteinemia in patients with active rheumatoid arthritis: effects

of disease activity, sex, and menopausal status on lipid profiles.

Yoo WH.

Division of Rheumatology, Department of Internal Medicine, Chonbuk

National University Medical School and Research Institute of Clinical

Medicine, Chonju, South Korea.

OBJECTIVE: To investigate the lipid profiles in patients with active

rheumatoid arthritis (RA) and to assess the relationship of inflammatory

disease activity markers, sex, and menopausal status with lipid

profiles. METHODS: Three groups of patients with active RA (n = 184)

were studied: men (n = 61, mean age 50.8 +/- 4.81 yrs), premenopausal

women (n = 58, mean age 39.2 +/- 2.44 yrs), and postmenopausal women (n

= 65, mean age 60.4 +/- 2.14 yrs), and healthy controls (n = 161): men

(n = 65, mean age 50.9 +/- 3.42 yrs), premenopausal women (n = 47, mean

age 40.3 +/- 1.66 yrs), and postmenopausal women (n = 49, mean age 61.3

+/- 3.16 yrs). We measured fasting plasma levels of total cholesterol

(TC), triglyceride (TG), HDL-cholesterol (HDL-C), LDL-cholesterol

(LDL-C), lipoprotein (a) [LP(a)], apolipoprotein A1 (apo A1),

apolipoprotein B (apo , and erythrocyte sedimentation rate (ESR) and

C-reactive protein (CRP). RESULTS: Male RA patients had significantly

higher apo B/apo A1 and LP(a) and lower HDL-C than male controls. Female

RA patients had significantly higher TC, LDL-C, and LP(a) than female

controls. Premenopausal RA patients had significantly higher LDL-C,

TC/HDL-C, LDL-C/HDL-C, and apo B/apo A1 and lower TG and HDL-C than

premenopausal controls. Postmenopausal RA women had significantly higher

TG and LP(a) and lower TC than postmenopausal controls. Female RA

patients had higher HDL-C, apo A1, and TC/HDL-C and lower apo B/apo A1

than male RA patients. Postmenopausal RA patients had significantly

higher TC, TG, TC/HDL-C, apo B, LP(a), and LDL-C/HDL-C than

premenopausal RA patients. CRP correlated positively with TC/HDL-C,

LDL-C/HDL-C, and apo B/apo A1 and negatively with HDL-C in male RA

patients. In female RA patients CRP had positive correlation with

TC/HDL-C and LDL-C/HDL-C and negative correlation with HDL-C.

CONCLUSION: These findings suggest that patients with active RA have

altered lipid profiles and that disease activity, sex, and menopausal

status affect lipid profiles, and these would be expected to change the

pattern of atherosclerotic events in RA.

PMID: 15338494

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

5338494 & dopt=Abstract

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