Efficacy and Safety of COX-2 Inhibitors vs. NSAIDs

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American Family Physician

February 15, 2002

" Efficacy and Safety of COX-2 Inhibitors vs. NSAIDs " :

" Despite having no greater clinical efficacy in the treatment of

arthritis than standard, nonselective, nonsteroidal anti-inflammatory

drugs (NSAIDs), the selective cyclooxygenase-2 (COX-2) inhibitors

(celecoxib and rofecoxib) are being widely prescribed because of their

decreased potential for adverse gastrointestinal effects. FitzGerald and

Patrono present an in-depth review of the pharmacology and clinical

effects of selective COX-2 inhibitors, including a discussion of a

possibly increased incidence of cardiovascular and renal disease among

patients using these agents. "

http://www.aafp.org/afp/20020215/tips/5.html

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Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org