Guest guest Posted August 19, 2000 Report Share Posted August 19, 2000 For those of us who have at least a degree of interest in, and optimism about, herbs and other " alternative " medicines, the following article may be worth looking into (or rather, what may be worth looking into is the compound studied here). If anyone has access to a really comprehensive book about herbs, or better yet a well-informed herbologist, please ask them about this compound -- the ethanol extract from the root wood of Cudrania cochinchinensis var. gerontogea (Moraceae). Thanks, and please let us know what you find. Ezra Am J Chin Med 1999;27(2):227-39 Related Articles, Books, LinkOut The anti-inflammatory and hepatoprotective effects of fractions from Cudrania cochinchinensis var. gerontogea. Lin CC, Lee HY, Chang CH, Yang JJ School of Pharmacy, Kaohsiung Medical College, Taiwan. Various fractions of the ethanol extract from the root wood of Cudrania cochinchinensis var. gerontogea (Moraceae) were evaluated for their anti-inflammatory effects on carrageenan-induced edema and hepatoprotective activities on carbon tetrachloride (CCl4)-induced and D-galactosamine-(D-GalN) induced acute hepatotoxicity in rats. The fractions (n-hexane, CHCl3, EtOAc, n-BuOH, and H2O) displayed significant inhibitory activity against carrageenan-induced edema, and the active anti-inflammatory components were further localized in the n-BuOH fraction, which exhibited the greatest anti-inflammatory effect, an effect 5% greater than indomethacin (which was used as a standard reference substance). Each fraction exerted a significant hepatoprotective effect by reducing enzymatic alteration (sGOT and sGPT) and by improving hepatic lesions, including liver centrilobular inflammation, cell necrosis, fatty change, ballooning degeneration in CCl4-induced acute hepatitis; and necrosis of the portal area in D-GalN-induced acute liver injury. The n-BuOH and EtOAc fractions had the greatest hepatoprotective effects on CCl4-induced liver injury; in contrast, the CHCl3 fraction was most potent against D-GalN intoxication, which is comparable to silymarin, as a recognized hepatoprotective drug. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 19, 2000 Report Share Posted August 19, 2000 Ezra, I am forwarding this to my brother and sil who are both pharmacists. They might be able to find out more. I will let you know when I hear from them. Thanks for your insight about my cousins PSC and itching. It makes sense to me. I forgot to say that his bili is at 4 right now and has been as high as 6. I wasn't upset about your observation about the possible familial factor. In fact I have wondered about the same possibility with ulcerative colitis. My maternal grandfather probably had it (tests weren't available in the 40's) and he didn't even have indoor plumbing yet. My brother also had UC but has not developed PSC. This cousin who has PSC is from my father's side of the family. Dad was the oldest of 14 children and my cousins mom was child no. 8 or 9 so I didn't have much contact with him as we were growing up plus we didn't live real close. I would imagine that we will develop a bond through this disease. Barby married 21 years, mom of 5 sons- KS UC - dx in 1965 (11yo), ostomy 1972, BCIR (continent ostomy)1994 PSC- dx in 1999 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 21, 2000 Report Share Posted August 21, 2000 Ezra, Okay, I'm out of the closet, I have some papers at home about this stuff....it had peaked my interest a couple of weeks ago, I'm pretty sure that's what they were written on, I'll dig them out (have patience, you have NO idea how I file things...), when I find them I'll let you know. I have access to a wonderful herb book at a local pharmacy (that sucker is BIG), I'll look it up there also, Patti >From: Iszat@... >Reply-To: egroups >To: egroups >Subject: Re: An Herbal Lead >Date: Sat, 19 Aug 2000 20:08:37 EDT > >For those of us who have at least a degree of interest in, and optimism >about, herbs and other " alternative " medicines, the following article may >be >worth looking into (or rather, what may be worth looking into is the >compound >studied here). If anyone has access to a really comprehensive book about >herbs, or better yet a well-informed herbologist, please ask them about >this >compound -- the ethanol extract from the root wood of Cudrania >cochinchinensis var. gerontogea (Moraceae). Thanks, and please let us know >what you find. Ezra > >Am J Chin Med 1999;27(2):227-39 Related Articles, Books, LinkOut > >The anti-inflammatory and hepatoprotective effects of fractions from >Cudrania >cochinchinensis var. gerontogea. > >Lin CC, Lee HY, Chang CH, Yang JJ > >School of Pharmacy, Kaohsiung Medical College, Taiwan. > >Various fractions of the ethanol extract from the root wood of Cudrania >cochinchinensis var. gerontogea (Moraceae) were evaluated for their >anti-inflammatory effects on carrageenan-induced edema and hepatoprotective >activities on carbon tetrachloride (CCl4)-induced and >D-galactosamine-(D-GalN) induced acute hepatotoxicity in rats. The >fractions >(n-hexane, CHCl3, EtOAc, n-BuOH, and H2O) displayed significant inhibitory >activity against carrageenan-induced edema, and the active >anti-inflammatory >components were further localized in the n-BuOH fraction, which exhibited >the >greatest anti-inflammatory effect, an effect 5% greater than indomethacin >(which was used as a standard reference substance). Each fraction exerted a >significant hepatoprotective effect by reducing enzymatic alteration (sGOT >and sGPT) and by improving hepatic lesions, including liver centrilobular >inflammation, cell necrosis, fatty change, ballooning degeneration in >CCl4-induced acute hepatitis; and necrosis of the portal area in >D-GalN-induced acute liver injury. The n-BuOH and EtOAc fractions had the >greatest hepatoprotective effects on CCl4-induced liver injury; in >contrast, >the CHCl3 fraction was most potent against D-GalN intoxication, which is >comparable to silymarin, as a recognized hepatoprotective drug. > ________________________________________________________________________ Get Your Private, Free E-mail from MSN Hotmail at http://www.hotmail.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 22, 2000 Report Share Posted August 22, 2000 In a message dated 8/19/00 5:09:07 PM Pacific Daylight Time, Iszat@... writes: > or those of us who have at least a degree of interest in, and optimism > about, herbs and other " alternative " medicines, the following article may be > > worth looking into (or rather, what may be worth looking into is the > compound > studied here). If anyone has access to a really comprehensive book about > herbs, or better yet a well-informed herbologist, please ask them about this > compound -- the ethanol extract from the root wood of Cudrania > cochinchinensis var. gerontogea (Moraceae). Thanks, and please let us know > what you find. Ezra Ezra, I tried to look up Cudrania in the 1998 PDR for herbal remedies but there was no info on it. Sorry. Adam Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.