Guest guest Posted November 30, 1999 Report Share Posted November 30, 1999 : Somebody needs to figure out how we can get CEUs for reading all of your email. Now that's a project I'd support! Ha! Melody Malouf ************************** >Gene, > >You are correct, to a point. > >Treatment of organophosphate (OP) poisoning consists of the >administration >of atropine, a drug that blocks the effects of the excess >acetylcholine >(ACh) at muscarinic ACh receptor sites; and of 2-pyrdine >aldoxime methyl >chloride (2-PAM Cl, also called pralidoxime chloride), an >oxime that will >remove the OP from acetylcholinestrase (AChE), thereby >reactivating the >enzyme after poisoning by OP. However, it is ineffective >against OP once >they have " aged " . Ventilatory support is necessary when >breathing has >stopped or is inadequate, and the anticonvulsante diazepam >(Valium) may need >to be administered (these patients convulse with large >exposures). > >Aging is a process by which one of the OP's alkyl groups >leaves the >molecule. After de-alkylation, an AChE-bound nerve agent >molecule can no >longer be removed from the enzyme by an oxime. The aging >process varies from >OP to OP (I have no figures, sorry). > >2-PAM Cl is an oxime that increases the rate of breakdown of >the OP-AChE >complex to regenerate the AChE (in effect, the 2-PAM Cl > " pries " the OP from >the AChE, think 2-PAM crowbar). 2-PAM Cl ameliorates muscle >weakness, >fasciculations, and alterations of consciousness, it does NOT >relieve >bronchospasm or bronchorrhea. It is synergistic with >atropine. Dose: >600-1800 mg IM or 1g IV SLOWLY; may repeat 600 mg or 1 g dose >every hour up >to three times. > >The BIGGEST factors to OP treatment are: >1> avoid exposing yourself (routes are inhalation and >absorption); >2> decontaminate the patient THOROUGHLY (skin exposure is >possible); >3> airway and respiratory support; >4> atropine until secretions are dried and airway is open; >5> 2-PAM Cl if available (give it EARLY on). > >Keep safe all, > Webb > >______________________________________________________ > >------------------------------------------------------ ---------- >-------- >Buy 1 Get 2 FREE at FamilyWonder.com! Choose from over 50,000 >videos >and CDs! FamilyWonder.com is dedicated to helping parents and >friends >make the best possible purchase decisions for children. >http://clickhere./click/1807 > > >-- 20 megs of disk space in your group's Document Vault >-- /docvault//?m=1 > > > Quote Link to comment Share on other sites More sharing options...
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