Re: Biologics with MTX - how much MTX?

[Guest guest]

My rheumy gave me a choice between Enbrel or Humira, since I couldn't

take mtx because of a low white blood cell count. He said that Remicade

works much better along with mtx.

So I guess in his opinion, Enbrel or Humira can be effective alone if

mtx cannot be tolerated. This has proven true for me, since Enbrel is

working very well to control my RA. Perhaps you could eliminate the mtx

eventually and still have good results.

Sue

On Monday, September 20, 2004, at 01:23 PM, Jennie G wrote:

> For those of you on Enbrel, Remicade or Humira, and who also take

> mtx, how much mtx do you take?

>

> I've been having some hair loss from mtx and we tried increasing the

> folic acid. It helped for a while but now it's worse. I suggested

> decreasing my dose of mtx and my rheumy said we could try that. We

> had previously said we would decrease, but not eliminate, mtx after I

> got of prednisone anyway, and I'm down to 1mg. I was on 17.5mgs of

> mtx each week (pills) and am now going to 15mgs.

>

> I'm wondering how much mtx others take, when in combination with one

> of the biologics? a or , do you know if the study that said

> the biologics are more effective in combination with mtx, if they

> stated how much mtx? If the going down to 15mgs doesn't help, I'm

> wondering if an even lower dose would be an option.

>

> Jennie

>

>

>

>

>

[Guest guest]

My rheumy gave me a choice between Enbrel or Humira, since I couldn't

take mtx because of a low white blood cell count. He said that Remicade

works much better along with mtx.

So I guess in his opinion, Enbrel or Humira can be effective alone if

mtx cannot be tolerated. This has proven true for me, since Enbrel is

working very well to control my RA. Perhaps you could eliminate the mtx

eventually and still have good results.

Sue

On Monday, September 20, 2004, at 01:23 PM, Jennie G wrote:

> For those of you on Enbrel, Remicade or Humira, and who also take

> mtx, how much mtx do you take?

>

> I've been having some hair loss from mtx and we tried increasing the

> folic acid. It helped for a while but now it's worse. I suggested

> decreasing my dose of mtx and my rheumy said we could try that. We

> had previously said we would decrease, but not eliminate, mtx after I

> got of prednisone anyway, and I'm down to 1mg. I was on 17.5mgs of

> mtx each week (pills) and am now going to 15mgs.

>

> I'm wondering how much mtx others take, when in combination with one

> of the biologics? a or , do you know if the study that said

> the biologics are more effective in combination with mtx, if they

> stated how much mtx? If the going down to 15mgs doesn't help, I'm

> wondering if an even lower dose would be an option.

>

> Jennie

>

>

>

>

>

[Guest guest]

Although Enbrel and Humira work without mtx, according to my rheumy,

I'm going to do better with it. If I had low white blood cell

count, I'd be off mtx. Mild hair loss probably isn't a good enough

reason to stop it. But if the results can be as good with say, 12.5

or 10mgs, and the lower dose stops my hair from falling out, then

I'm all for that. Everything posted above says the studies

that showed patients did better on a combination of a biological and

mtx, showed a mean mtx dose of 15-17 or so mgs. So I'm not sure if

there is a basis for a lower dose (given no real threat to my health

to stay on it).

Jennie

> My rheumy gave me a choice between Enbrel or Humira, since I

couldn't

> take mtx because of a low white blood cell count. He said that

Remicade

> works much better along with mtx.

> So I guess in his opinion, Enbrel or Humira can be effective alone

if

> mtx cannot be tolerated. This has proven true for me, since Enbrel

is

> working very well to control my RA. Perhaps you could eliminate

the mtx

> eventually and still have good results.

>

> Sue

>

>

[Guest guest]

Although Enbrel and Humira work without mtx, according to my rheumy,

I'm going to do better with it. If I had low white blood cell

count, I'd be off mtx. Mild hair loss probably isn't a good enough

reason to stop it. But if the results can be as good with say, 12.5

or 10mgs, and the lower dose stops my hair from falling out, then

I'm all for that. Everything posted above says the studies

that showed patients did better on a combination of a biological and

mtx, showed a mean mtx dose of 15-17 or so mgs. So I'm not sure if

there is a basis for a lower dose (given no real threat to my health

to stay on it).

Jennie

> My rheumy gave me a choice between Enbrel or Humira, since I

couldn't

> take mtx because of a low white blood cell count. He said that

Remicade

> works much better along with mtx.

> So I guess in his opinion, Enbrel or Humira can be effective alone

if

> mtx cannot be tolerated. This has proven true for me, since Enbrel

is

> working very well to control my RA. Perhaps you could eliminate

the mtx

> eventually and still have good results.

>

> Sue

>

>

[Guest guest]

Sue, Remicade, Enbrel, and Humira can be effective without MTX; however,

a growing number of studies show, most particularly with Remicade (and

in its clinical trials), that, generally speaking, they are all MORE

effective with MTX.

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

Re: [ ] Biologics with MTX - how much MTX?

> My rheumy gave me a choice between Enbrel or Humira, since I couldn't

> take mtx because of a low white blood cell count. He said that

Remicade

> works much better along with mtx.

> So I guess in his opinion, Enbrel or Humira can be effective alone if

> mtx cannot be tolerated. This has proven true for me, since Enbrel is

> working very well to control my RA. Perhaps you could eliminate the

mtx

> eventually and still have good results.

>

> Sue

[Guest guest]

Sue, Remicade, Enbrel, and Humira can be effective without MTX; however,

a growing number of studies show, most particularly with Remicade (and

in its clinical trials), that, generally speaking, they are all MORE

effective with MTX.

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

Re: [ ] Biologics with MTX - how much MTX?

> My rheumy gave me a choice between Enbrel or Humira, since I couldn't

> take mtx because of a low white blood cell count. He said that

Remicade

> works much better along with mtx.

> So I guess in his opinion, Enbrel or Humira can be effective alone if

> mtx cannot be tolerated. This has proven true for me, since Enbrel is

> working very well to control my RA. Perhaps you could eliminate the

mtx

> eventually and still have good results.

>

> Sue

[Guest guest]

Jennie, you may have noticed that I only posted the studies I could find

that were related to Humira and MTX for you since that's what you're on.

Not only that, but they were looking at cases where response to MTX was

inadequate.

There are many studies out there for all of the anti-TNF biologics, but

I don't have access to the full text in many instances and can't see

what the dosages of MTX were. So, for now, that's the best I can do with

your Humira and MTX question.

It's very hard to know what to conclude for you specifically since there

is so much variation between individuals.

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[ ] Re: Biologics with MTX - how much MTX?

> Although Enbrel and Humira work without mtx, according to my rheumy,

> I'm going to do better with it. If I had low white blood cell

> count, I'd be off mtx. Mild hair loss probably isn't a good enough

> reason to stop it. But if the results can be as good with say, 12.5

> or 10mgs, and the lower dose stops my hair from falling out, then

> I'm all for that. Everything posted above says the studies

> that showed patients did better on a combination of a biological and

> mtx, showed a mean mtx dose of 15-17 or so mgs. So I'm not sure if

> there is a basis for a lower dose (given no real threat to my health

> to stay on it).

>

> Jennie

[Guest guest]

Jennie, you may have noticed that I only posted the studies I could find

that were related to Humira and MTX for you since that's what you're on.

Not only that, but they were looking at cases where response to MTX was

inadequate.

There are many studies out there for all of the anti-TNF biologics, but

I don't have access to the full text in many instances and can't see

what the dosages of MTX were. So, for now, that's the best I can do with

your Humira and MTX question.

It's very hard to know what to conclude for you specifically since there

is so much variation between individuals.

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[ ] Re: Biologics with MTX - how much MTX?

> Although Enbrel and Humira work without mtx, according to my rheumy,

> I'm going to do better with it. If I had low white blood cell

> count, I'd be off mtx. Mild hair loss probably isn't a good enough

> reason to stop it. But if the results can be as good with say, 12.5

> or 10mgs, and the lower dose stops my hair from falling out, then

> I'm all for that. Everything posted above says the studies

> that showed patients did better on a combination of a biological and

> mtx, showed a mean mtx dose of 15-17 or so mgs. So I'm not sure if

> there is a basis for a lower dose (given no real threat to my health

> to stay on it).

>

> Jennie

[Guest guest]

Thank you for looking! We'll see what happens at 15mgs of mtx. I'm

not very confident it will stop the hair loss. It's not so much

hair loss, but it is not fun to see it always falling out. I know

my mom had this happening for 10 years and I could never tell a

difference, it was just thinner. But my hair is also longer and it

takes forever to grow. I have fast growing nails, but slow growing

hair. I wish I could switch that. I never let my nails get long or

paint them, but I am very attached to having shoulder length hair.

I was trying hard to not let it bother me, but as you can see, I am

loosing that battle.

Jennie

> Jennie, you may have noticed that I only posted the studies I

could find

> that were related to Humira and MTX for you since that's what

you're on.

> Not only that, but they were looking at cases where response to

MTX was

> inadequate.

>

> There are many studies out there for all of the anti-TNF

biologics, but

> I don't have access to the full text in many instances and can't

see

> what the dosages of MTX were. So, for now, that's the best I can

do with

> your Humira and MTX question.

>

> It's very hard to know what to conclude for you specifically since

there

> is so much variation between individuals.

>

>

>

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>

>

[Guest guest]

Thank you for looking! We'll see what happens at 15mgs of mtx. I'm

not very confident it will stop the hair loss. It's not so much

hair loss, but it is not fun to see it always falling out. I know

my mom had this happening for 10 years and I could never tell a

difference, it was just thinner. But my hair is also longer and it

takes forever to grow. I have fast growing nails, but slow growing

hair. I wish I could switch that. I never let my nails get long or

paint them, but I am very attached to having shoulder length hair.

I was trying hard to not let it bother me, but as you can see, I am

loosing that battle.

Jennie

> Jennie, you may have noticed that I only posted the studies I

could find

> that were related to Humira and MTX for you since that's what

you're on.

> Not only that, but they were looking at cases where response to

MTX was

> inadequate.

>

> There are many studies out there for all of the anti-TNF

biologics, but

> I don't have access to the full text in many instances and can't

see

> what the dosages of MTX were. So, for now, that's the best I can

do with

> your Humira and MTX question.

>

> It's very hard to know what to conclude for you specifically since

there

> is so much variation between individuals.

>

>

>

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>

>

[Guest guest]

, I'm very thankful that Enbrel alone is so effective for me, since

I can't take mtx. I don't know what other DMARD could be combined with

the Enbrel for me. But right now, I'm glad that it's time for my

injection tonight. I rode for three hours on Saturday and for two and a

half hours yesterday, and I don't think it did my RA a bit of good,

LOL. Sue

On Monday, September 20, 2004, at 09:13 PM, wrote:

> Sue, Remicade, Enbrel, and Humira can be effective without MTX;

> however,

> a growing number of studies show, most particularly with Remicade (and

> in its clinical trials), that, generally speaking, they are all MORE

> effective with MTX.

[Guest guest]

, I'm very thankful that Enbrel alone is so effective for me, since

I can't take mtx. I don't know what other DMARD could be combined with

the Enbrel for me. But right now, I'm glad that it's time for my

injection tonight. I rode for three hours on Saturday and for two and a

half hours yesterday, and I don't think it did my RA a bit of good,

LOL. Sue

On Monday, September 20, 2004, at 09:13 PM, wrote:

> Sue, Remicade, Enbrel, and Humira can be effective without MTX;

> however,

> a growing number of studies show, most particularly with Remicade (and

> in its clinical trials), that, generally speaking, they are all MORE

> effective with MTX.

[Guest guest]

I'm also glad that the Enbrel alone is working for you, Sue. Problem is

that we can't tell in advance who will be OK with monotherapy.

Hope your injection gets you back to normal!

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

Re: [ ] Biologics with MTX - how much MTX?

>

> , I'm very thankful that Enbrel alone is so effective for me,

since

> I can't take mtx. I don't know what other DMARD could be combined with

> the Enbrel for me. But right now, I'm glad that it's time for my

> injection tonight. I rode for three hours on Saturday and for two and

a

> half hours yesterday, and I don't think it did my RA a bit of good,

> LOL. Sue

[Guest guest]

I'm also glad that the Enbrel alone is working for you, Sue. Problem is

that we can't tell in advance who will be OK with monotherapy.

Hope your injection gets you back to normal!

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

Re: [ ] Biologics with MTX - how much MTX?

>

> , I'm very thankful that Enbrel alone is so effective for me,

since

> I can't take mtx. I don't know what other DMARD could be combined with

> the Enbrel for me. But right now, I'm glad that it's time for my

> injection tonight. I rode for three hours on Saturday and for two and

a

> half hours yesterday, and I don't think it did my RA a bit of good,

> LOL. Sue

[Guest guest]

, I couldn't ask for Enbrel to work any better. I just hope it

continues to work forever. Yes, my injection got me back to normal. I

was afraid I might be having a flare. I've never had one, except the

original one when I first got RA that lasted at least a year and a

half, until I was put on Arava and then Enbrel.

Sue

On Monday, September 20, 2004, at 10:21 PM, wrote:

> I'm also glad that the Enbrel alone is working for you, Sue. Problem is

> that we can't tell in advance who will be OK with monotherapy.

>

> Hope your injection gets you back to normal!

>

[Guest guest]

, I couldn't ask for Enbrel to work any better. I just hope it

continues to work forever. Yes, my injection got me back to normal. I

was afraid I might be having a flare. I've never had one, except the

original one when I first got RA that lasted at least a year and a

half, until I was put on Arava and then Enbrel.

Sue

On Monday, September 20, 2004, at 10:21 PM, wrote:

> I'm also glad that the Enbrel alone is working for you, Sue. Problem is

> that we can't tell in advance who will be OK with monotherapy.

>

> Hope your injection gets you back to normal!

>

[Guest guest]

Jennie, what about going up to 5 mg per day on the folic acid? Also, try

not to worry too much about dropping down to 15 mg. Since you've said

you're smaller than average, you may have more MTX available to your

system than the average person on 15 mg per week.

Let's hope for the best with your hair!

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[ ] Re: Biologics with MTX - how much MTX?

>

> Thank you for looking! We'll see what happens at 15mgs of mtx. I'm

> not very confident it will stop the hair loss. It's not so much

> hair loss, but it is not fun to see it always falling out. I know

> my mom had this happening for 10 years and I could never tell a

> difference, it was just thinner. But my hair is also longer and it

> takes forever to grow. I have fast growing nails, but slow growing

> hair. I wish I could switch that. I never let my nails get long or

> paint them, but I am very attached to having shoulder length hair.

> I was trying hard to not let it bother me, but as you can see, I am

> loosing that battle.

>

> Jennie

[Guest guest]

Jennie, what about going up to 5 mg per day on the folic acid? Also, try

not to worry too much about dropping down to 15 mg. Since you've said

you're smaller than average, you may have more MTX available to your

system than the average person on 15 mg per week.

Let's hope for the best with your hair!

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[ ] Re: Biologics with MTX - how much MTX?

>

> Thank you for looking! We'll see what happens at 15mgs of mtx. I'm

> not very confident it will stop the hair loss. It's not so much

> hair loss, but it is not fun to see it always falling out. I know

> my mom had this happening for 10 years and I could never tell a

> difference, it was just thinner. But my hair is also longer and it

> takes forever to grow. I have fast growing nails, but slow growing

> hair. I wish I could switch that. I never let my nails get long or

> paint them, but I am very attached to having shoulder length hair.

> I was trying hard to not let it bother me, but as you can see, I am

> loosing that battle.

>

> Jennie

[Guest guest]

,

I did ask about increasing the folic acid. My rheumy said more than

2mgs per day would just get flushed out of my system. In the UK,

don't they take 5mgs per week? So I'm taking almost three times

that, plus whatever is in my multivitamin. In any case, my rheumy

didn't think that increasing the folic acid would help.

So far dropping from 17.5mg to 15mgs of mtx at the same time as

dropping from 2mgs to 1mg of prednisone, I've only had a slight

amount of joint pain. It would just be wonderful if the decrease in

mtx helped my hair loss. I'm crossing my fingers.

You may be right about the dose and my size. I'm only 5'0 " and about

96 lbs. I think the 17.5mgs of mtx was somewhat arbitrary to begin

with. I remember starting out at 12.5mgs and increasing it twice.

But it is also true that sometimes when I think something is

arbitrary, it is just that my rheumy kept the logic behind it to

himself. I love my rheumy, but sometimes he has me on a need-to-know

basis. Two months ago when I went in still complaining about the

joint near my achilles, he gave me some exercises and injected it

with novicane (he said too much risk using cortizone, could damage

the achilles). I asked him how long will the novicane last, and his

response was, " You'll see. " He was right. I found out in about

three days that it would last about three days.

Jennie

> Jennie, what about going up to 5 mg per day on the folic acid?

Also, try

> not to worry too much about dropping down to 15 mg. Since you've

said

> you're smaller than average, you may have more MTX available to your

> system than the average person on 15 mg per week.

>

> Let's hope for the best with your hair!

>

>

>

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>

>

[Guest guest]

,

I did ask about increasing the folic acid. My rheumy said more than

2mgs per day would just get flushed out of my system. In the UK,

don't they take 5mgs per week? So I'm taking almost three times

that, plus whatever is in my multivitamin. In any case, my rheumy

didn't think that increasing the folic acid would help.

So far dropping from 17.5mg to 15mgs of mtx at the same time as

dropping from 2mgs to 1mg of prednisone, I've only had a slight

amount of joint pain. It would just be wonderful if the decrease in

mtx helped my hair loss. I'm crossing my fingers.

You may be right about the dose and my size. I'm only 5'0 " and about

96 lbs. I think the 17.5mgs of mtx was somewhat arbitrary to begin

with. I remember starting out at 12.5mgs and increasing it twice.

But it is also true that sometimes when I think something is

arbitrary, it is just that my rheumy kept the logic behind it to

himself. I love my rheumy, but sometimes he has me on a need-to-know

basis. Two months ago when I went in still complaining about the

joint near my achilles, he gave me some exercises and injected it

with novicane (he said too much risk using cortizone, could damage

the achilles). I asked him how long will the novicane last, and his

response was, " You'll see. " He was right. I found out in about

three days that it would last about three days.

Jennie

> Jennie, what about going up to 5 mg per day on the folic acid?

Also, try

> not to worry too much about dropping down to 15 mg. Since you've

said

> you're smaller than average, you may have more MTX available to your

> system than the average person on 15 mg per week.

>

> Let's hope for the best with your hair!

>

>

>

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>

>

[Guest guest]

Jennie, some rheumatologists in the UK recommend 5 mg of folic acid

daily. In the US, the ACR recommends 1 mg per day.

Here's an interesting study:

Rheumatology 2000; 39: 1102 - 1109

" Do patients with rheumatoid arthritis established on methotrexate and

folic acid 5 mg daily need to continue folic acid supplements long

term? " :

http://rheumatology.oupjournals.org/cgi/content/full/39/10/1102

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[ ] Re: Biologics with MTX - how much MTX?

> ,

>

> I did ask about increasing the folic acid. My rheumy said more than

> 2mgs per day would just get flushed out of my system. In the UK,

> don't they take 5mgs per week? So I'm taking almost three times

> that, plus whatever is in my multivitamin. In any case, my rheumy

> didn't think that increasing the folic acid would help.

>

> So far dropping from 17.5mg to 15mgs of mtx at the same time as

> dropping from 2mgs to 1mg of prednisone, I've only had a slight

> amount of joint pain. It would just be wonderful if the decrease in

> mtx helped my hair loss. I'm crossing my fingers.

>

> You may be right about the dose and my size. I'm only 5'0 " and about

> 96 lbs. I think the 17.5mgs of mtx was somewhat arbitrary to begin

> with. I remember starting out at 12.5mgs and increasing it twice.

> But it is also true that sometimes when I think something is

> arbitrary, it is just that my rheumy kept the logic behind it to

> himself. I love my rheumy, but sometimes he has me on a need-to-know

> basis. Two months ago when I went in still complaining about the

> joint near my achilles, he gave me some exercises and injected it

> with novicane (he said too much risk using cortizone, could damage

> the achilles). I asked him how long will the novicane last, and his

> response was, " You'll see. " He was right. I found out in about

> three days that it would last about three days.

>

> Jennie

>

>

> > Jennie, what about going up to 5 mg per day on the folic acid?

> Also, try

> > not to worry too much about dropping down to 15 mg. Since you've

> said

> > you're smaller than average, you may have more MTX available to your

> > system than the average person on 15 mg per week.

> >

> > Let's hope for the best with your hair!

> >

> >

> >

> >

> > I'll tell you where to go!

> >

> > Mayo Clinic in Rochester

> > http://www.mayoclinic.org/rochester

> >

> > s Hopkins Medicine

> > http://www.hopkinsmedicine.org

> >

> >

>

>

>

>

[Guest guest]

Jennie, some rheumatologists in the UK recommend 5 mg of folic acid

daily. In the US, the ACR recommends 1 mg per day.

Here's an interesting study:

Rheumatology 2000; 39: 1102 - 1109

" Do patients with rheumatoid arthritis established on methotrexate and

folic acid 5 mg daily need to continue folic acid supplements long

term? " :

http://rheumatology.oupjournals.org/cgi/content/full/39/10/1102

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[ ] Re: Biologics with MTX - how much MTX?

> ,

>

> I did ask about increasing the folic acid. My rheumy said more than

> 2mgs per day would just get flushed out of my system. In the UK,

> don't they take 5mgs per week? So I'm taking almost three times

> that, plus whatever is in my multivitamin. In any case, my rheumy

> didn't think that increasing the folic acid would help.

>

> So far dropping from 17.5mg to 15mgs of mtx at the same time as

> dropping from 2mgs to 1mg of prednisone, I've only had a slight

> amount of joint pain. It would just be wonderful if the decrease in

> mtx helped my hair loss. I'm crossing my fingers.

>

> You may be right about the dose and my size. I'm only 5'0 " and about

> 96 lbs. I think the 17.5mgs of mtx was somewhat arbitrary to begin

> with. I remember starting out at 12.5mgs and increasing it twice.

> But it is also true that sometimes when I think something is

> arbitrary, it is just that my rheumy kept the logic behind it to

> himself. I love my rheumy, but sometimes he has me on a need-to-know

> basis. Two months ago when I went in still complaining about the

> joint near my achilles, he gave me some exercises and injected it

> with novicane (he said too much risk using cortizone, could damage

> the achilles). I asked him how long will the novicane last, and his

> response was, " You'll see. " He was right. I found out in about

> three days that it would last about three days.

>

> Jennie

>

>

> > Jennie, what about going up to 5 mg per day on the folic acid?

> Also, try

> > not to worry too much about dropping down to 15 mg. Since you've

> said

> > you're smaller than average, you may have more MTX available to your

> > system than the average person on 15 mg per week.

> >

> > Let's hope for the best with your hair!

> >

> >

> >

> >

> > I'll tell you where to go!

> >

> > Mayo Clinic in Rochester

> > http://www.mayoclinic.org/rochester

> >

> > s Hopkins Medicine

> > http://www.hopkinsmedicine.org

> >

> >

>

>

>

>