CASE REPORT - Rheumatoid nodules of the larynx

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J Laryngol Otol. 1998 Jun;112(6):573-4.

Rheumatoid nodules of the larynx.

Sorensen WT, Moller-Andersen K, Behrendt N.

Department of Otolaryngology, Glostrup Hospital, Copenhagen, Denmark.

A 67-year-old woman with rheumatoid arthritis was hospitalized because

of dysphagia and severe nodulosis. Over a two-year period the patient

had been treated with methotrexate. A computed tomography (CT) scan of

the neck showed a 2 x 2 cm large tumour behind the top left lateral

thyroid cartilage. A biopsy taken during direct laryngoscopy showed it

was a rheumatic nodule. Treatment with colchicine reduced the patient's

dysphagia. As methotrexate is used increasingly in the treatment of

rheumatoid arthritis and as this particular drug causes rheumatic

nodules in five to 10 per cent of the patients, it must be foreseen that

the incidence of nodules in the upper airways will increase.

PMID: 9764301

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=9764301 & itool=iconabstr

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