RESEARCH - Hand BMD and its associations with radiographic joint damage and fractures in 50-70 year old female patients with RA

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Ann Rheum Dis. 2004 Oct;63(10):1331-4.

Hand cortical bone mass and its associations with radiographic joint

damage and fractures in 50-70 year old female patients with rheumatoid

arthritis: cross sectional Oslo-Truro-Amsterdam (OSTRA) collaborative

study.

Haugeberg G, Lodder MC, Lems WF, Uhlig T, ORstavik RE, Dijkmans BA,

Kvien TK, Woolf AD.

Department of Rheumatology, Sorlandet Hospital, N-4604 Kristiansand S,

Norway. glenn.haugeberg@...

OBJECTIVE: To investigate the relationship between hand bone mineral

density (BMD) and radiographic joint damage, and between hand BMD and

fractures in 50-70 year old women with longstanding RA. METHODS:

Demographic, clinical data, and imaging data on hand radiographs and

Genants vertebral deformity score on spine radiographs were collected

from 135 women with RA of >/=5 years, recruited from three European

rheumatology clinics. Metacarpal hand BMD was measured by digital hand x

ray radiogrammetry (DXR), and hip and lumbar spine BMD by dual x ray

absorptiometry (DXA). Multiple regression analyses were used to examine

associations between hand BMD and radiographic joint damage, and hand

BMD and fractures. RESULTS: Hand BMD was strongly and independently

associated with radiographic hand joint damage in a linear regression

model adjusted for age, centre, BMI, disease duration, RF, 18 deformed

joint count, ESR, and femoral neck BMD. In a multivariate logistic

regression model adjusted for relevant variables, hand BMD and femoral

neck BMD, but not spine BMD, were independently associated with

vertebral deformities and with non-vertebral fractures.

CONCLUSION: BMD measured by DXR on conventional hand radiographs in

patients with RA may potentially be used as an indicator of joint damage

and of vertebral and non-vertebral fracture risk.

PMID: 15361395

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

5361395 & dopt=Abstract

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