Re: RESEARCH - Blood pressure destabilization and edema among 8538 users of Celebrex, Vioxx, and NS NSAIDs and nonusers of NSAIDs receiving ordinary clinical care

[Guest guest]

I'm a statistic of this study. Since being off of Vioxx, my pressure

dropped to 100/60 which is normal for me.

When I complained that Vioxx increased my BP, the doctor looked at me like I

was nuts because my pressure was 120/80 or 130/80 and they didn't think it

was so bad. For me it was high. If the doctor paid any attention, he'd

have know it too.

a

> J Rheumatol. 2004 Jun;31(6):1143-51.

>

>

> Blood pressure destabilization and edema among 8538 users of celecoxib,

> rofecoxib, and nonselective nonsteroidal antiinflammatory drugs (NSAID)

> and nonusers of NSAID receiving ordinary clinical care.

>

>

> Wolfe F, Zhao S, Pettitt D.

>

> National Data Bank for Rheumatic Diseases, Arthritis Research Center

> Foundation, Wichita, KS 67214, USA. fwolfe@...

>

> OBJECTIVE: To investigate the relationship between nonselective

> nonsteroidal antiinflammatory drugs (NS NSAID), rofecoxib, celecoxib,

> and risk of edema and blood pressure destabilization in patients with

> rheumatoid arthritis (RA) and osteoarthritis (OA) receiving ordinary

> clinic care. METHODS: Patients participating in a longterm outcome study

> reported drug use, as well as the presence of edema and blood pressure

> increases occurring during the previous 6 months. To measure pure drug

> effect, analyses were restricted to 8538 patients who exclusively used a

> NS NSAID, rofecoxib, or celecoxib, and compared to nonusers of NS NSAID,

> rofecoxib, or celecoxib. We evaluated blood pressure destabilization

> using patient-reported increases in blood pressure and/or difficulty in

> controlling blood pressure. RESULTS: Compared with nonusers, after

> adjusting for age, sex, presence of RA, and history of heart disease and

> hypertension, patients using rofecoxib, but not celecoxib or NS NSAID,

> had an increased rate of edema (23.3% vs 18.0%), while the rates for

> celecoxib and NS NSAID were 17.5% and 18.2%, respectively. The adjusted

> risk of edema was significantly increased for rofecoxib compared to

> celecoxib (OR 1.33, 95% CI 1.08-1.64). For blood pressure increases,

> among patients who did not report having hypertension, no significant

> increase was noted for NS NSAID and celecoxib compared with nonusers.

> However a significant increased risk of blood pressure increase was seen

> for rofecoxib (OR 2.08, 95% CI 1.41-3.06). Among patients who reported

> having hypertension, patients taking rofecoxib had a significant

> increase

> ed risk of blood pressure increase compared to nonusers (OR 1.55, 95% CI

> 1.23-1.96), while the risks of blood pressure increase for users of

> celecoxib and NS NSAID were not significantly different than among

> nonusers. After controlling for age, sex, RA, and new starts on NSAID,

> the risk of blood pressure increase was significantly higher for users

> of rofecoxib than celecoxib (OR 1.21, 95% CI 1.03-1.61) among patients

> with hypertension, and numerically higher for nonhypertensives (OR 1.42,

> 95% CI 0.96-2.22). The increased risk for hypertension and edema of

> rofecoxib compared to celecoxib users was further confirmed by analysis

> of specific reported side effects during 2 separate 6-month periods

> (July 1 to December 31, 1999, and January 1 to June 30, 2000). During

> these 2 periods, rofecoxib-treated patients were 2.16 to 3.82 times more

> likely to report edema or blood pressure increase side effects compared

> to celecoxib-treated patients.

>

> CONCLUSION: Rofecoxib, but not celecoxib and NS NSAID, is associated

> with an increased risk of edema and blood pressure increase compared to

> nonusers of NSAID.

>

> PMID: 15170928

>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids

> =15170928 & dopt=Abstract

>

>

>

>

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>

>

>

>

>

[Guest guest]

I'm a statistic of this study. Since being off of Vioxx, my pressure

dropped to 100/60 which is normal for me.

When I complained that Vioxx increased my BP, the doctor looked at me like I

was nuts because my pressure was 120/80 or 130/80 and they didn't think it

was so bad. For me it was high. If the doctor paid any attention, he'd

have know it too.

a

> J Rheumatol. 2004 Jun;31(6):1143-51.

>

>

> Blood pressure destabilization and edema among 8538 users of celecoxib,

> rofecoxib, and nonselective nonsteroidal antiinflammatory drugs (NSAID)

> and nonusers of NSAID receiving ordinary clinical care.

>

>

> Wolfe F, Zhao S, Pettitt D.

>

> National Data Bank for Rheumatic Diseases, Arthritis Research Center

> Foundation, Wichita, KS 67214, USA. fwolfe@...

>

> OBJECTIVE: To investigate the relationship between nonselective

> nonsteroidal antiinflammatory drugs (NS NSAID), rofecoxib, celecoxib,

> and risk of edema and blood pressure destabilization in patients with

> rheumatoid arthritis (RA) and osteoarthritis (OA) receiving ordinary

> clinic care. METHODS: Patients participating in a longterm outcome study

> reported drug use, as well as the presence of edema and blood pressure

> increases occurring during the previous 6 months. To measure pure drug

> effect, analyses were restricted to 8538 patients who exclusively used a

> NS NSAID, rofecoxib, or celecoxib, and compared to nonusers of NS NSAID,

> rofecoxib, or celecoxib. We evaluated blood pressure destabilization

> using patient-reported increases in blood pressure and/or difficulty in

> controlling blood pressure. RESULTS: Compared with nonusers, after

> adjusting for age, sex, presence of RA, and history of heart disease and

> hypertension, patients using rofecoxib, but not celecoxib or NS NSAID,

> had an increased rate of edema (23.3% vs 18.0%), while the rates for

> celecoxib and NS NSAID were 17.5% and 18.2%, respectively. The adjusted

> risk of edema was significantly increased for rofecoxib compared to

> celecoxib (OR 1.33, 95% CI 1.08-1.64). For blood pressure increases,

> among patients who did not report having hypertension, no significant

> increase was noted for NS NSAID and celecoxib compared with nonusers.

> However a significant increased risk of blood pressure increase was seen

> for rofecoxib (OR 2.08, 95% CI 1.41-3.06). Among patients who reported

> having hypertension, patients taking rofecoxib had a significant

> increase

> ed risk of blood pressure increase compared to nonusers (OR 1.55, 95% CI

> 1.23-1.96), while the risks of blood pressure increase for users of

> celecoxib and NS NSAID were not significantly different than among

> nonusers. After controlling for age, sex, RA, and new starts on NSAID,

> the risk of blood pressure increase was significantly higher for users

> of rofecoxib than celecoxib (OR 1.21, 95% CI 1.03-1.61) among patients

> with hypertension, and numerically higher for nonhypertensives (OR 1.42,

> 95% CI 0.96-2.22). The increased risk for hypertension and edema of

> rofecoxib compared to celecoxib users was further confirmed by analysis

> of specific reported side effects during 2 separate 6-month periods

> (July 1 to December 31, 1999, and January 1 to June 30, 2000). During

> these 2 periods, rofecoxib-treated patients were 2.16 to 3.82 times more

> likely to report edema or blood pressure increase side effects compared

> to celecoxib-treated patients.

>

> CONCLUSION: Rofecoxib, but not celecoxib and NS NSAID, is associated

> with an increased risk of edema and blood pressure increase compared to

> nonusers of NSAID.

>

> PMID: 15170928

>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids

> =15170928 & dopt=Abstract

>

>

>

>

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>

>

>

>

>