RESEARCH - Effects of gabapentin (Neurontin) on anxiety induced by simulated public speaking

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J Psychopharmacol. 2003 Jun;17(2):184-8.

Effects of gabapentin on anxiety induced by simulated public speaking.

de-Paris F, Sant' MK, Vianna MR, Barichello T, Busnello JV,

Kapczinski F, Quevedo J, Izquierdo I.

Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias

Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto

Alegre, Brasil.

The effects of gabapentin, 400 mg and 800 mg, on anxiety induced by

simulated public speaking (SPS) were investigated. Thirty-two normal

male volunteers (aged 17-30 years) had their anxiety and mood evaluated

by self-scales [Visual Analogue Mood Scale (VAMS) and Profile of Mood

State (POMS)] during the SPS procedure. Physiological measures (heart

rate and blood pressure) were taken. Treatment with gabapentin at 800 mg

attenuated the anxiety of subjects that had a decrease on the VAMS item

calm-excite. In addition, volunteers that received gabapentin at 400 mg

and 800 mg showed a decrease in the hostility score in POMS. Our results

suggest, in agreement with other studies, an anxiolytic potential to

gabapentin.

PMID: 12870565

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

2870565 & dopt=Abstract

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