Stress makes you forgetful, kinase C protein undermines short term memory

October 29, 2004

29 Oct 2004

According to a new study, stress makes you activate an enzyme in the brain

called Kinase C, it is a protein which undermines your short term memory,

plus some other brain functions in the prefrontal cortex. The prefrontal

cortex is the executive decision making section of your brain.

Ask any actor who is stressed with stage fright, or a student just before an

important exam and they will tell you this (losing memory) is old news.

This new study, led by Dr Amy Arnsten, Yale Medical School, USA, has managed

to pinpoint why your short term memory is affected when you are experiencing

stress.

You can read about this study in the journal Science.

Experts say this study could help scientists and doctors acquire a better

insight in how to treat people with bipolar disorder and schizophrenia.

Kinase C (PKC) is an enzyme which is active in patients with bipolar

disorder and schizophrenia. Dr. Arnsten found that a psychotic episode often

comes after some stressful encounter. Arnsten gave, as examples of stressful

situations, leaving home to go to college or joining the armed forces.

Perhaps PKC plays a part in making patients more distracted, impulsive and

have bad judgment (common during psychotic episodes).

Perhaps new drugs could target PKC production, said Arnsten.

Dr. Arnsten said ŒThese new findings may also help us understand the

impulsivity and distractibility observed in children with lead poisoning.

Very low levels of lead can activate PKC, and this may lead to impaired

regulation of behavior.'

In this study Arnsten and team induced stress in rats and monkeys (by

administering chemicals). The stress would be similar to what we would feel

when exposed to a loud noise, or the jitters we may feel before an exam.

Arnsten said ŒIt doesn't have to be traumatic, as long as you feel out of

control. Control is the essential factor. If you are confident, you don't

have these problems. " She went on to say that memory and the ability to use

abstract thoughts are impaired. ŒThis kind of memory (using working memory

that is constantly being updated), the ability to concentrate, seems to be

impaired when exposed to mild stresses.'

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