Re: Israeli Metformin Study

[Guest guest]

And Ron Sebol followed up in LC-DIABETES re our discussion about the

findings in the Israeli study ...

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Len Sauer wrote:

<< The key reference is Antihyperglycemic Treatment in Diabetics with

Coronary Disease: Increased Metformin-Associated Mortality over a 5-Year

Follow-Up. Cardiology 1999 Sep;91(3):195-202. >>

It appears that the same mistake that pegged Metformin as a cardio risk in

earlier studies mayhap is being repeated half a world away. Metformin is a

vitamin B antagonist. Diabetics need extra vitamin B to begin with, because

of poorer utilization. The two add up to enough of a vitamin B shortfall to

elevate homocysteine. A person using Metformin had better be taking a

B-complex supplement.

When a study fails to account for proper vitamin B management in association

with Metformin and heart risk, or at least frequent measurement of

homocysteine, said study should be dismissed. I suggest that you screen

that text and let us know if there is any explicit mention of having

controlled for that confounding factor.

Betcha betcha they blew it.