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Hi, All. Hope you are having a good summer. Ours has been very hot and humid.

We are so happy that Phil has his new liver. He is the only other person with PSC that I have met personally and we have a special relationship with he and . Feel like family, so we are so delighted that he now has a new life and I know he will have a quick recovery.

I went to the liver research unit to day to sign a consent form for the study they are doing. First of all I will be having an ERCP and 2 ml. of bile will be removed. The bile removed will be analyzed for TGFB ( a protein that causes the formation of scar tissue). If it is elevated I will then proceed to the treatment phase of the study. I will then be randomly assigned to one of two treatment groups. Group 1 treatment

with 20 mg Tamoxifen per day for a total of six months.

Group two: Treatment with placebo, one tab per day for six months. It won't be starting for a few weeks but I will keep you informed.

Enjoy the rest of the summer and take care,

Leona

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