Re: 'blackout' on vitamin D news and PSA / PC research

[Guest guest]

It is my opinion that in the past a lot of downright silly research has been

done targeting

the androgen-bogeymen testosterone and DHT. The fact that

differentiating therapies upregulate the androgen receptor (AR) seems

at first sight a terrible thing to happen if you are striving for

'undetectable PSA nadir' as some well-known plaudits of castration

therapy insist upon. However once you realise that upregulating the AR

will increase androgen production via the HPG

(hypothalamus-pituitary-gonadal) axis if permitted; AND that androgen

levels at the normal-high end of the male spectrum actually kill

prostate cancer cells by differentiation-apoptosis you have a

completely alternative scenario. Its like looking at that picture of

an old woman and suddenly seeing the young girl.

http://mathworld.wolfram.com/YoungGirl-OldWomanIllusion.html

My point concerning the 'blackout' on news about vitamin D and in

particular Vieth's Pilot Study is serious and I will not dilute what I

have to say just so that old folks can stay in their comfort zone and

avoid challenge. That is not going to get us anywhere, and it means

yet another generation down the line will have to deal with the issues

that have been swept under the carpet by this generation.

Jacquie, I know you care, but sometimes I disagree with you. Just a few years

ago you complained bitterly about a new Medicare ruling for

men having to transfer from Lupron to the less expensive Zoladex. You

complained on the grounds that the Zoladex needle was " bigger " . If you

had done your homework you would have realised that a Zoladex needle

penetrating skin into adipose tissue (where the Zoladex pellet is

deposited) is far less painful than a smaller needle penetrating skin

into muscle. There are no pain sensors in fat tissue, but there are

plenty in muscle.

So thanks for the advice Jacquie, , but as your way does not work

and will never work, I will do my thing my way.

Sammy.

[Guest guest]

>Jacquie,>Just what point are you making? I am not quite sure, but it does not>address the Subject line that some critical information is being withheld >at a supposedly leading PC informational source that is, incidentally but>perhaps not coincidentally, financially supported by the pharmaceutical >industry.Sammy, first I was addressing your statement:>** vitamin D UPREGULATES PSA expression and downregulates PC growth.>Synergistic action with androgen upregulates by a factor of x50 ! I thought you had a point there, which is more interesting that the blackhole. At the same time, how far this and related information has been suppressed or cast into a black hole, I question. That's why I brought up some of the literature and recalled that my husband took a differentiation agent plus an anti-angiogenisis agent in a trial in 1994 (and the latter, INF, has now turned out to upregulate androgen receptor, as pointed out by an inestimable member of the community today:Oncogene. 2006 May 4;25(19):2812-7.Androgen receptor levels are increased by interferons in human prostatestromal and epithelial cells.Basrawala Z, et al. Department of Urology, Loyola University Chicago, and Hines Jr VA Hospital, Hines, IL 60141, USA.http://tinyurl.com/r6o2mNow, maybe research on vitamin D, say, might have received more attention sooner with more usable results if big drug companies stood to make billions from it. I don't know. But if you Google vitamin D, prostate cancer, you get 2,250,000 results.You may be right to hold that better ways of dealing with prostate cancer are available at low cost -- or even cures for malaria -- which may take decades for the mainstream to appropriate and start turning into profit. That's the way it goes. Regarding your overall outlook on "astroturf" as it's called on this side of the Atlantic, see:http://www.prwatch.org/prwissues/2003Q1/astroturf.htmlI did a little bit on this topic in '97 at the bottom of this page (understandably, this was of small interest to real world patients living with cancer (including Norman). And making little cartoons was a way of cheering myself up as I looked dark thoughts in the eye):http://www.psa-rising.com/specials/chickenpage.htmI salute your stamina, Sammy. The question is how to use energies to best effect. If you are a living example of the success of your own protocol, if you have important information to share, you certainly have a right and a duty to share it where prostate cancer patients gather, and to do so in the most straightforward, least alienating way possible. If this is what you have striven to do and you have been repeatedly rebuffed or excluded purely on the basis of the information itself, you have cause ... but for what? People don't understand? They're skeptical, cautious (both good things to be)? They only respect info coming from a doctor? They want to see results of clinical trials? Don't give in but please don't get sidelined or distracted into polemic. If you have a better way, people will read and listen. bestJacquiehttp://www.psa-rising.com/med/hormonal/urologist-influence.html