Re: Thank You Carmen Foundation

[Guest guest]

Its good to see those donations going to good use. Thank you Marjorie!

Courage

Thank You " Carmen Foundation "

I was reading one of our members blogs - Living with Lewy -

(http://livingwithlewybody.blogspot.com/) - and fell upon a page from

March 2008 - an update from Marjorie Carmen:

http://livingwithlewybody.blogspot.com/search/label/Marjorie%20Carmen

It excited me b/c a donation from the Carmen Foundation was given to

MassGeneral Institute for Neurodegenerative Disease (MIND) to help

with research that benefits LBD. (Also a donation to LBDA!)

Went to MIND's website and it's listed right there on the home page:

http://www.mghmind.org/

Click 2008 Research:

http://www.mghmind.org/pdf/Research_Review_2008.pdf

Read the article entitled:

Collaboration Leads to Potential Drug for Parkinsons

I believe this is the official article in Science that they're

referring to:

July 2007

Sirtuin 2 Inhibitors Rescue -Synuclein-Mediated Toxicity in Models of

Parkinson's Disease

The sirtuins are members of the histone deacetylase family of

proteins that participate in a variety of cellular functions and play

a role in aging. We identified a potent inhibitor of sirtuin 2

(SIRT2) and found that inhibition of SIRT2 rescued -synuclein

toxicity and modified inclusion morphology in a cellular model of

Parkinson's disease. Genetic inhibition of SIRT2 via small

interfering RNA similarly rescued -synuclein toxicity. Furthermore,

the inhibitors protected against dopaminergic cell death both in

vitro and in a Drosophila model of Parkinson's disease. The results

suggest a link between neurodegeneration and aging.

Source: http://www.sciencemag.org/cgi/content/abstract/317/5837/516

This is all very exciting.

Not sure if Marjorie is part of our group here. But if so, THANK YOU!