Neurobiological principles in the etiopathogenesis of disease: When diseases hav

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Med Sci Monit. 2009 Jan;15(1):RA6-16.

Neurobiological principles in the etiopathogenesis of disease: When

diseases have a head.

Mravec B, Ondicova K, Valaskova Z, Gidron Y, Hulin I.

Institute of Pathophysiology, Faculty of Medicine, Comenius

University, Bratislava, Slovak Republic and Institute of Experimental

Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak

Republic.

There is no doubt that the nervous system is involved in the

etiopathogenesis of various pathological states and diseases.

Interactions between the nervous, endocrine, and immune systems might

represent the anatomical and functional basis for understanding the

pathways and mechanisms that enable the brain to modulate the

progression of disease. The aim of this article is to encourage us to

shift our current opinion of the etiopathogenesis of disease to one

of highly complex interactions between peripheral tissues and the

brain and in this way introduce new diagnostic and therapeutic

approaches.