Stachybotrys chartarum, a mold suggested to play an etiologic role in damp build

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Satratoxin G-Induced Apoptosis in PC-12 Neuronal Cells is Mediated by PKR and

Caspase Independent (2008)

Islam, Zahidul, Hegg, Colleen C., Bae, Hee Kyong, Pestka, J.

Satratoxin G (SG) is a macrocyclic trichothecene mycotoxin produced by

Stachybotrys chartarum, a mold suggested to play an etiologic role in damp

building-related illnesses. Acute intranasal exposure...

Deoxynivalenol Induces p38 Interaction with the Ribosome in Monocytes and

Macrophages (2008)

Bae, Hee Kyong, Pestka, J.

Trichothecene mycotoxins rapidly induce p38-mediated gene expression and

apoptosis in mononuclear phagocytes via a process known as the ribotoxic stress

response. We hypothesized that the...

Comparative Induction of 28S Ribosomal RNA Cleavage by Ricin and the

Trichothecenes Deoxynivalenol and T-2 Toxin in the Macrophage (2008)

Li, Maoxiang, Pestka, J.

Ribosome-inactivating proteins (RIPs) and sesquiterpenoid trichothecene

mycotoxins are known to bind to eukaryotic ribosomes, inhibit translation and

activate mitogen-activated protein kinases. Here...

Double-Stranded RNA-Activated Protein Kinase Mediates Induction of Interleukin-8

Expression by Deoxynivalenol, Shiga Toxin 1, and Ricin in Monocytes (2008)

Gray, S., Bae, Hee Kyong, Li, C. B., Lau, Allan S., Pestka,

J.

Translational inhibitors such as the trichothecene mycotoxin deoxynivalenol

(DON) and ribosomal inhibitory proteins (RIPs) induce mitogen-activated protein

kinase (MAPK)–driven chemokine and...

Stachybotrys chartarum, Trichothecene Mycotoxins, and Damp Building-Related

Illness: New Insights into a Public Health Enigma (2008)

Pestka, J., Yike, Iwona, Dearborn, Dorr G., Ward, Marsha D. W., Harkema,

Jack R.

Damp building–related illnesses (DBRI) include a myriad of respiratory,

immunologic, and neurologic symptoms that are sometimes etiologically linked to

aberrant indoor growth of the toxic black...

Transcriptional Regulation of Deoxynivalenol-Induced IL-8 Expression in Human

Monocytes (2007)

Gray, S., Pestka, J.

The trichothecene mycotoxin deoxynivalenol (DON), commonly present in

contaminated grains worldwide, induces expression of the chemokine interleukin

(IL)-8 in human monocytes. The purpose of this...

Deoxynivalenol Exacerbates Viral Bronchopneumonia Induced by Respiratory

Reovirus Infection (2007)

Li, Maoxiang, Harkema, Jack R., Cuff, F., Pestka, J.

The trichothecene mycotoxin deoxynivalenol (DON), a frequent contaminant of

cereal grains, is known to dysregulate mucosal and systemic immunity. In this

study, we tested the hypothesis that DON...

Comparative effects of the herbal constituent parthenolide (Feverfew) on

lipopolysaccharide-induced inflammatory gene expression in murine spleen and

liver (2005)

Smolinski, a T, Pestka, J

Abstract Background Parthenolide, a major sesquiterpene lactone present in

extracts of the herb Feverfew, has been investigated for its inhibitory effects

on mediators of inflammation, including the...

Ribotoxic Stress Response to the Trichothecene Deoxynivalenol in the Macrophage

Involves the Src Family Kinase Hck (2005)

Zhou, Hui-Ren, Jia, Qunshan, Pestka, J.

Trichothecene mycotoxins and other translational inhibitors activate

mitogen-activated protein kinase (MAPKs) by a mechanism called the " ribotoxic

stress response, " which drives both cytokine...

Induction of Competing Apoptotic and Survival Signaling Pathways in the

Macrophage by the Ribotoxic Trichothecene Deoxynivalenol (2005)

Zhou, Hui-Ren, Islam, Zahidul, Pestka, J.

Deoxynivalenol (DON) and other ribotoxic trichothecenes cause immune stimulation

and suppression in leukocytes by upregulating gene expression and apoptosis,

respectively. The purpose of this study...

Rapid, Sequential Activation of Mitogen-Activated Protein Kinases and

Transcription Factors Precedes Proinflammatory Cytokine mRNA Expression in

Spleens of Mice Exposed to the Trichothecene Vomitoxin (Deoxynivalenol) (2003)

Zhou, Hui-Ren, Islam, Zahidul, Pestka, J.

Since proinflammatory cytokine mRNA expression is induced within lymphoid tissue

in vivo by the trichothecene vomitoxin (VT) in a rapid (1-2 hr) and transient

(4-8 hr) fashion, it was hypothesized...

Role of IL-1 " " in Endotoxin Potentiation of Deoxynivalenol-Induced

Corticosterone Response and Leukocyte Apoptosis in Mice (2003)

Islam, Zahidul, Pestka, J.

Endotoxin (lipopolysaccharide, LPS) and the trichothecenes are microbial toxins

that are frequently encountered in food and the environment. Co-exposure to LPS

and the trichothecene deoxynivalenol...

Role of Double-Stranded RNA-Activated Protein Kinase R (PKR) in

Deoxynivalenol-Induced Ribotoxic Stress Response (2003)

Zhou, Hui-Ren, Lau, Allan S., Pestka, J.

Trichothecene mycotoxins and other protein synthesis inhibitors activate

mitogen-activated protein kinase (MAPKs) via a mechanism that has been termed

the " ribotoxic stress response " . MAPKs are...

Role of IL-1{beta} in Endotoxin Potentiation of Deoxynivalenol-Induced

Corticosterone Response and Leukocyte Apoptosis in Mice (2003)

Islam, Zahidul, Pestka, J.

Endotoxin (lipopolysaccharide, LPS) and the trichothecenes are microbial toxins

that are frequently encountered in food and the environment. Coexposure to LPS

and the trichothecene deoxynivalenol...

Rapid, Sequential Activation of Mitogen-Activated Protein Kinases and

Transcription Factors Precedes Proinflammatory Cytokine mRNA Expression in

Spleens of Mice Exposed to the Trichothecene Vomitoxin (2003)

Zhou, Hui-Ren, Islam, Zahidul, Pestka, J.

Since proinflammatory cytokine mRNA expression is induced within lymphoid tissue

in vivo by the trichothecene vomitoxin (VT) in a rapid (1–2 h) and transient

(4–8 h) fashion, it was hypothesized...

Rapid, Sequential Activation of Mitogen-Activated Protein Kinases and

Transcription Factors Precedes Proinflammatory Cytokine mRNA Expression in

Spleens of Mice Exposed to the Trichothecene Vomitoxin (Deoxynivalenol) (2003)

Zhou, Hui-Ren, Islam, Zahidul, Pestka, J.

Since proinflammatory cytokine mRNA expression is induced within lymphoid tissue

in vivo by the trichothecene vomitoxin (VT) in a rapid (1-2 hr) and transient

(4-8 hr) fashion, it was hypothesized...

Role of IL-1 " " in Endotoxin Potentiation of Deoxynivalenol-Induced

Corticosterone Response and Leukocyte Apoptosis in Mice (2003)

Islam, Zahidul, Pestka, J.

Endotoxin (lipopolysaccharide, LPS) and the trichothecenes are microbial toxins

that are frequently encountered in food and the environment. Co-exposure to LPS

and the trichothecene deoxynivalenol...

Role of Double-Stranded RNA-Activated Protein Kinase R (PKR) in

Deoxynivalenol-Induced Ribotoxic Stress Response (2003)

Zhou, Hui-Ren, Lau, Allan S., Pestka, J.

Trichothecene mycotoxins and other protein synthesis inhibitors activate

mitogen-activated protein kinase (MAPKs) via a mechanism that has been termed

the " ribotoxic stress response " . MAPKs are...

Vomitoxin-Induced Cyclooxygenase-2 Gene Expression in Macrophages Mediated by

Activation of ERK and p38 but Not JNK Mitogen-Activated Protein Kinases (2002)

Moon, Yuseok, Pestka, J.

Vomitoxin (VT) and other trichothecene mycotoxins mediate a broad range of

immunotoxic effects via the induction of inflammation-associated genes in

leukocytes. The purpose of this study was to test...

Lipopolysaccharide and the Trichothecene Vomitoxin (Deoxynivalenol)

Synergistically Induce Apoptosis in Murine Lymphoid Organs (2000)

Zhou, Hui-Ren, Harkema, Jack R., Hotchkiss, Jon A., Yan, Ding, Roth, A.,

Pestka, J.

Human exposure to Gram-negative bacterial lipopolysaccharide (LPS) is common and

may have an important influence on chemical toxicity. LPS has been shown

previously to enhance synergistically the...

Persistent Dysregulation of IgA Production and IgA Nephropathy in the B6C3F1

Mouse Following Withdrawal of Dietary Vomitoxin (Deoxynivalenol) (1993)

DONG, WUMIN, PESTKA, JAMES J.

To assess whether vomitoxin-induced dysregulation of IgA production and IgA

nephropathy are reversible, relevant immunologic parameters were compared among

experimental groups of B6C3F1 mice that...

Identification of Mimotope Peptides Which Bind to the Mycotoxin

Deoxynivalenol-Specific Monoclonal Antibody

Yuan, Qiaoping, Pestka, J., Hespenheide, M., Kuhn, A.,

Linz, E., Hart, L.

Monoclonal antibody 6F5 (mAb 6F5), which recognizes the mycotoxin deoxynivalenol

(DON) (vomitoxin), was used to select for peptides that mimic the mycotoxin by

employing a library of filamentous...

Expression of a Functional Antizearalenone Single-Chain Fv Antibody in

Transgenic Arabidopsis Plants

Yuan, Qiaoping, Hu, Wenqi, Pestka, J., He, Sheng Yang, Hart, L.

The efficacy of cloning a recombinant mycotoxin antibody in plants was tested

using Arabidopsis as a model. An antizearalenone single-chain Fv (scFv) DNA

fragment was first cloned in the newly...

Comparative effects of the herbal constituent parthenolide (Feverfew) on

lipopolysaccharide-induced inflammatory gene expression in murine spleen and

liver

Smolinski, a T, Pestka, J

Satratoxin G from the Black Mold Stachybotrys chartarum Evokes Olfactory Sensory

Neuron Loss and Inflammation in the Murine Nose and Brain

Islam, Zahidul, Harkema, Jack R., Pestka, J.

Satratoxin G (SG) is a macrocyclic trichothecene mycotoxin produced by

Stachybotrys chartarum, the " black mold " suggested to contribute etiologically

to illnesses associated with water-damaged...

Identification of Mimotope Peptides Which Bind to the Mycotoxin

Deoxynivalenol-Specific Monoclonal Antibody

Yuan, Qiaoping, Pestka, J., Hespenheide, M., Kuhn, A.,

Linz, E., Hart, L.

Monoclonal antibody 6F5 (mAb 6F5), which recognizes the mycotoxin deoxynivalenol

(DON) (vomitoxin), was used to select for peptides that mimic the mycotoxin by

employing a library of filamentous...

Expression of a Functional Antizearalenone Single-Chain Fv Antibody in

Transgenic Arabidopsis Plants

Yuan, Qiaoping, Hu, Wenqi, Pestka, J., He, Sheng Yang, Hart, L.

The efficacy of cloning a recombinant mycotoxin antibody in plants was tested

using Arabidopsis as a model. An antizearalenone single-chain Fv (scFv) DNA

fragment was first cloned in the newly...

Comparative effects of the herbal constituent parthenolide (Feverfew) on

lipopolysaccharide-induced inflammatory gene expression in murine spleen and

liver

Smolinski, a T, Pestka, J

Satratoxin G from the Black Mold Stachybotrys chartarum Evokes Olfactory Sensory

Neuron Loss and Inflammation in the Murine Nose and Brain

Islam, Zahidul, Harkema, Jack R., Pestka, J.

Satratoxin G (SG) is a macrocyclic trichothecene mycotoxin produced by

Stachybotrys chartarum, the " black mold " suggested to contribute etiologically

to illnesses associated with water-damaged...

Satratoxin G–Induced Apoptosis in PC-12 Neuronal Cells is Mediated by PKR and

Caspase Independent

Islam, Zahidul, Hegg, Colleen C., Bae, Hee Kyong, Pestka, J.

Satratoxin G (SG) is a macrocyclic trichothecene mycotoxin produced by

Stachybotrys chartarum, a mold suggested to play an etiologic role in damp

building-related illnesses. Acute intranasal exposure...

Comparative Induction of 28S Ribosomal RNA Cleavage by Ricin and the

Trichothecenes Deoxynivalenol and T-2 Toxin in the Macrophage

Li, Maoxiang, Pestka, J.

Ribosome-inactivating proteins (RIPs) and sesquiterpenoid trichothecene

mycotoxins are known to bind to eukaryotic ribosomes, inhibit translation and

activate mitogen-activated protein kinases. Here...