Re: Thank You Carmen Foundation

[Guest guest]

Found another article about the Carmen Foundation:

Diagnosing a mystery

Lewy body disease is often mistaken for other types of dementia

May 08. 2008

In 2003, Milton Carmen, a Yale-educated physicist and successful real

estate developer, noticed a disturbing trend. At age 79, he was

struggling to find the words he wanted to use. A neurologist

prescribed him a medication used to treat Alzheimer's disease.

The next year, while on a trip away from home, his left hand started

shaking. His doctors then diagnosed him with Parkinson's disease and

put him on another medication.

It was four neurologists later that Carmen and his wife, Marjorie,

who have since moved to Bend, first heard the term Lewy body disease .

" I thought at first it was good news, " she said, " because it's not

Parkinson's. "

Read More:

http://tinyurl.com/3mvupt

>

> I was reading one of our members blogs - Living with Lewy -

> (http://livingwithlewybody.blogspot.com/) - and fell upon a page

from

> March 2008 - an update from Marjorie Carmen:

> http://livingwithlewybody.blogspot.com/search/label/Marjorie%

20Carmen

>

> It excited me b/c a donation from the Carmen Foundation was given

to

> MassGeneral Institute for Neurodegenerative Disease (MIND) to help

> with research that benefits LBD. (Also a donation to LBDA!)

>

> Went to MIND's website and it's listed right there on the home page:

> http://www.mghmind.org/

>

> Click 2008 Research:

> http://www.mghmind.org/pdf/Research_Review_2008.pdf

> Read the article entitled:

> Collaboration Leads to Potential Drug for Parkinsons

>

> I believe this is the official article in Science that they're

> referring to:

>

> July 2007

> Sirtuin 2 Inhibitors Rescue -Synuclein-Mediated Toxicity in Models

of

> Parkinson's Disease

>

> The sirtuins are members of the histone deacetylase family of

> proteins that participate in a variety of cellular functions and

play

> a role in aging. We identified a potent inhibitor of sirtuin 2

> (SIRT2) and found that inhibition of SIRT2 rescued -synuclein

> toxicity and modified inclusion morphology in a cellular model of

> Parkinson's disease. Genetic inhibition of SIRT2 via small

> interfering RNA similarly rescued -synuclein toxicity. Furthermore,

> the inhibitors protected against dopaminergic cell death both in

> vitro and in a Drosophila model of Parkinson's disease. The results

> suggest a link between neurodegeneration and aging.

>

> Source: http://www.sciencemag.org/cgi/content/abstract/317/5837/516

>

> This is all very exciting.

>

> Not sure if Marjorie is part of our group here. But if so, THANK

YOU!

>

>

>