Acetaminophen and the risk of asthma

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Chest. 2005 Feb;127(2):604-12

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* Chest. 2005 Feb;127(2):427-9.

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*Acetaminophen and the risk of asthma: the epidemiologic and

pathophysiologic evidence.*

Eneli I, Sadri K, Camargo C Jr, Barr RG.

Department of Pediatrics and Human Development, Michigan State

University, B220 Clinical Center Bldg, East Lansing, MI 48824-1313,

USA. Eneli@...

The prevalence of asthma has increased worldwide. The reasons for

this rise remain unclear. Various studies have reported an

association between acetaminophen, a widely used analgesic, and

diagnosed asthma. In a prospective cohort study, the rate of newly

diagnosed asthma was 63% higher among frequent acetaminophen users

than nonusers in multivariate analyses. Studies of patients with

asthma suggest that acetaminophen challenge can precipitate a

decline in FEV(1) > 15% among sensitive individuals. Plausible

mechanisms to explain this association include depletion of

pulmonary glutathione and oxidative stress. This article reviews the

existing literature and evaluates the epidemiologic and

pathophysiologic evidence underlying a possible link between

acetaminophen and asthma.

Publication Types:

* Review

PMID: 15706003