Guest guest Posted January 2, 2008 Report Share Posted January 2, 2008 My daughter's ASO just came back 103.5[0-200] and Anti-DNase B Strep 1:340[adult<1:85]. ASO in the past has been lower. DNase has never been done. In prior years CRP has been elevated when my daughter seemed 'sick' to me - no symptoms that were objective like fever, elevated WBC, lethargy etc. ASO and anti-DNase were performed because 1)there's family history of strep problems[rheumatic fever] and 2)my daughter's nephew, now 8, has strep several times per year with his only symptom being OCD. He was on the spectrum as a toddler but is recovered except for this recurring strep issue. My questions - can the CRP also indicate this strep problem? Would cultures be of benefit? Where to culture - if the strep is deep in the bowel do throat/nasal cultures grow it? Do such cultures need extended growth time for chronic problems? If this has been a long term problem[she is 23 now and was ALWAYS better on penicillin the few times she had it as a as a toddler] what type of treatment could be beneficial? If penicillin, oral or IM? How long? Does ANti-DNase/ASO go down quickly with treatment? Does the strep/biofilm theory relate here - she has the elevated oxalates and hippuric acid on OAT. If so, does treatment with penicillin do much if the strep colonies are growing in a protected environment? does it need a longer course to be effective? Can I assume that a strep problem relates to seizure activity? Is CNS strep diagnosable independent of these blood levels? Sorry about all the ? I'm out of my league. Thanks, Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 2, 2008 Report Share Posted January 2, 2008 Dr. McCandless, Thanks. No specifics led to the strep test-just the family history, my grandchild's symptom pattern, wanting to assist my daughter and discussing it. No specifics led me to do the crp through direct labs either - just 'knowing' that my daughter was more ill than usual. The results for both surprised me. Seizures are not increasing and have been much better controlled on the lamictal. It is just a mom's gut telling me that she deals with this. When she was a toddler, she always seemed better on the penicillin but since she did not evidence overt symptoms, it was not a possibilty often. It's somewhat like the wart that's been in her ear much of her life telling me that she's a viral person. After reading about the theoretical strep association with elevated oxalates and hippuric and knowing my grandchild's and other family members' history, I thought it was worth mentioning again when she was seen. I could not think of any CNS diagnotics ex the tap and I sure wouldn't put her through that. I just have no idea if it needs addressing, with what and how long and what would tell us that it is in remission/gone. > > > My daughter's ASO just came back 103.5[0-200] and > > Anti-DNase B Strep > > 1:340[adult<1:85]. ASO in the past has been lower. > > DNase has never > > been done. In prior years CRP has been elevated when > > my daughter > > seemed 'sick' to me - no symptoms that were > > objective like fever, > > elevated WBC, lethargy etc. ASO and anti-DNase were > > performed because > > 1)there's family history of strep problems[rheumatic > > fever] and 2)my > > daughter's nephew, now 8, has strep several times > > per year with his > > only symptom being OCD. He was on the spectrum as a > > toddler but is > > recovered except for this recurring strep issue. My > > questions - can > > the CRP also indicate this strep problem? Would > > cultures be of > > benefit? Where to culture - if the strep is deep in > > the bowel do > > throat/nasal cultures grow it? Do such cultures need > > extended growth > > time for chronic problems? If this has been a long > > term problem[she > > is 23 now and was ALWAYS better on penicillin the > > few times she had > > it as a as a toddler] what type of treatment could > > be beneficial? If > > penicillin, oral or IM? How long? Does > > ANti-DNase/ASO go down quickly > > with treatment? Does the strep/biofilm theory relate > > here - she has > > the elevated oxalates and hippuric acid on OAT. If > > so, does treatment > > with penicillin do much if the strep colonies are > > growing in a > > protected environment? does it need a longer course > > to be effective? > > Can I assume that a strep problem relates to seizure > > activity? Is CNS > > strep diagnosable independent of these blood levels? > > Sorry about all > > the ? I'm out of my league. Thanks, > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 3, 2008 Report Share Posted January 3, 2008 This fall my son started having tics, and because of his history of regression after strep, we suspected that we had missed a strep infection. We took blood for titers, and then started a month long course of zithromax. The titers (ASO and dNase) both came back negative. After a week on the antibiotic, the frequency of tics was down about 50%,and then after 3 weeks, the tics were completely gone. Now a week and a half after stopping the antibiotic, the tics are back. Not sure what to think about this. We would like to restart the antibiotics (penicillin shots this time). Is the antibiotic really helping? I'm surprised the titers were negative. Thanks, > > > My daughter's ASO just came back 103.5[0-200] and > > Anti-DNase B Strep > > 1:340[adult<1:85]. ASO in the past has been lower. > > DNase has never > > been done. In prior years CRP has been elevated when > > my daughter > > seemed 'sick' to me - no symptoms that were > > objective like fever, > > elevated WBC, lethargy etc. ASO and anti-DNase were > > performed because > > 1)there's family history of strep problems[rheumatic > > fever] and 2)my > > daughter's nephew, now 8, has strep several times > > per year with his > > only symptom being OCD. He was on the spectrum as a > > toddler but is > > recovered except for this recurring strep issue. My > > questions - can > > the CRP also indicate this strep problem? Would > > cultures be of > > benefit? Where to culture - if the strep is deep in > > the bowel do > > throat/nasal cultures grow it? Do such cultures need > > extended growth > > time for chronic problems? If this has been a long > > term problem[she > > is 23 now and was ALWAYS better on penicillin the > > few times she had > > it as a as a toddler] what type of treatment could > > be beneficial? If > > penicillin, oral or IM? How long? Does > > ANti-DNase/ASO go down quickly > > with treatment? Does the strep/biofilm theory relate > > here - she has > > the elevated oxalates and hippuric acid on OAT. If > > so, does treatment > > with penicillin do much if the strep colonies are > > growing in a > > protected environment? does it need a longer course > > to be effective? > > Can I assume that a strep problem relates to seizure > > activity? Is CNS > > strep diagnosable independent of these blood levels? > > Sorry about all > > the ? I'm out of my league. Thanks, > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 3, 2008 Report Share Posted January 3, 2008 I'm assuming his titers are still negative, since they were negative before we started the antibiotics. > > > > > My daughter's ASO just came back 103.5[0-200] and > > > Anti-DNase B Strep > > > 1:340[adult<1:85]. ASO in the past has been lower. > > > DNase has never > > > been done. In prior years CRP has been elevated when > > > my daughter > > > seemed 'sick' to me - no symptoms that were > > > objective like fever, > > > elevated WBC, lethargy etc. ASO and anti-DNase were > > > performed because > > > 1)there's family history of strep problems[rheumatic > > > fever] and 2)my > > > daughter's nephew, now 8, has strep several times > > > per year with his > > > only symptom being OCD. He was on the spectrum as a > > > toddler but is > > > recovered except for this recurring strep issue. My > > > questions - can > > > the CRP also indicate this strep problem? Would > > > cultures be of > > > benefit? Where to culture - if the strep is deep in > > > the bowel do > > > throat/nasal cultures grow it? Do such cultures need > > > extended growth > > > time for chronic problems? If this has been a long > > > term problem[she > > > is 23 now and was ALWAYS better on penicillin the > > > few times she had > > > it as a as a toddler] what type of treatment could > > > be beneficial? If > > > penicillin, oral or IM? How long? Does > > > ANti-DNase/ASO go down quickly > > > with treatment? Does the strep/biofilm theory relate > > > here - she has > > > the elevated oxalates and hippuric acid on OAT. If > > > so, does treatment > > > with penicillin do much if the strep colonies are > > > growing in a > > > protected environment? does it need a longer course > > > to be effective? > > > Can I assume that a strep problem relates to seizure > > > activity? Is CNS > > > strep diagnosable independent of these blood levels? > > > Sorry about all > > > the ? I'm out of my league. Thanks, > > > > > > > > > > > > > > > ------------------------------------------------------------------------------ > > > No virus found in this incoming message. > Checked by AVG Free Edition. > Version: 7.5.516 / Virus Database: 269.17.13/1207 - Release Date: 1/2/2008 11:29 AM > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 3, 2008 Report Share Posted January 3, 2008 I've tried OLE in the past and it produced such nasty side effects - behavior that was 8-9 on a 10 point irritability scale. OLE may have been downing the critters and I didn't realize it! Did you titrate the dose up? What did you use as adult dose? how long? Thanks, > > > > > My daughter's ASO just came back 103.5[0-200] and > > > Anti-DNase B Strep > > > 1:340[adult<1:85]. ASO in the past has been lower. > > > DNase has never > > > been done. In prior years CRP has been elevated when > > > my daughter > > > seemed 'sick' to me - no symptoms that were > > > objective like fever, > > > elevated WBC, lethargy etc. ASO and anti-DNase were > > > performed because > > > 1)there's family history of strep problems[rheumatic > > > fever] and 2)my > > > daughter's nephew, now 8, has strep several times > > > per year with his > > > only symptom being OCD. He was on the spectrum as a > > > toddler but is > > > recovered except for this recurring strep issue. My > > > questions - can > > > the CRP also indicate this strep problem? Would > > > cultures be of > > > benefit? Where to culture - if the strep is deep in > > > the bowel do > > > throat/nasal cultures grow it? Do such cultures need > > > extended growth > > > time for chronic problems? If this has been a long > > > term problem[she > > > is 23 now and was ALWAYS better on penicillin the > > > few times she had > > > it as a as a toddler] what type of treatment could > > > be beneficial? If > > > penicillin, oral or IM? How long? Does > > > ANti-DNase/ASO go down quickly > > > with treatment? Does the strep/biofilm theory relate > > > here - she has > > > the elevated oxalates and hippuric acid on OAT. If > > > so, does treatment > > > with penicillin do much if the strep colonies are > > > growing in a > > > protected environment? does it need a longer course > > > to be effective? > > > Can I assume that a strep problem relates to seizure > > > activity? Is CNS > > > strep diagnosable independent of these blood levels? > > > Sorry about all > > > the ? I'm out of my league. Thanks, > > > > > > > > > > > > > > > -------------------------------------------------------------------- ---------- > > > No virus found in this incoming message. > Checked by AVG Free Edition. > Version: 7.5.516 / Virus Database: 269.17.13/1207 - Release Date: 1/2/2008 11:29 AM > > > Quote Link to comment Share on other sites More sharing options...
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