Re: TFNa in autism, Alzheimer: Rapid cognitive improvement in Alzheimer's diseas

[Guest guest]

Has anyone tried enbrel in a child with autism? If so, I haven't been

able to find any articles/references.

Thanks

>

> Tobinick and Gross seems free online

>

> - - - -

> <http://www.jneuroinflammation.com/content/5/1/2>*

> Rapid cognitive improvement in Alzheimer's disease following perispinal

> etanercept administration*

>

> L. Tobinick, Hyman Gross

> Journal of Neuroinflammation 2008, 5:2doi:10.1186/1742-2094-5-2

>

> [Provisional PDF

> <http://www.jneuroinflammation.com/content/pdf/1742-2094-5-2.pdf>]

>

>

> Abstract (provisional)

>

> Substantial basic science and clinical evidence suggests that excess

> tumor necrosis factor-alpha (TNF-alpha) is centrally involved in the

> pathogenesis of Alzheimer's disease. In addition to its

pro-inflammatory

> functions, TNF-alpha has recently been recognized to be a

> gliotransmitter that regulates synaptic function in neural networks.

> TNF-alpha has also recently been shown to mediate the disruption in

> synaptic memory mechanisms, which is caused by beta-amyloid and

> beta-amyloid oligomers. The efficacy of etanercept, a biologic

> antagonist of TNF-alpha, delivered by perispinal administration, for

> treatment of Alzheimer's disease over a period of six months has been

> previously reported in a pilot study. This report details rapid

> cognitive improvement, beginning within minutes, using this same

> anti-TNF treatment modality, in a patient with late-onset Alzheimer's

> disease. Rapid cognitive improvement following perispinal etanercept

may

> be related to amelioration of the effects of excess TNF-alpha on

> synaptic mechanisms in Alzheimer's disease and provides a promising

area

> for additional investigation and therapeutic intervention.

>

> * * * *

>

> *1: Pediatr Neurol. *2007 Jun;36(6):361-5.

>

>

> *Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of

> autistic children.*

>

> Chez MG, Dowling T, Patel PB, Khanna P, Kominsky M.

>

> Department of Neurology, lind lin University, and the Chicago

> Medical School, North Chicago, IL, USA. chezm2@...

>

> Recent reports implicating elevated cytokines in the central nervous

> system in a small number of patients studied with autism have reported

> clinical regression. These studies have not focused on tumor necrosis

> factor-alpha as a possible marker for inflammatory damage. A series of

> 10 children with autism had clinical evaluation of their serum and

> spinal fluid for inflammatory changes and possible metabolic disease as

> part of their neurological evaluation. Elevation of cerebrospinal fluid

> levels of tumor necrosis factor-alpha was significantly higher (mean =

> 104.10 pg/mL) than concurrent serum levels (mean = 2.78 pg/mL) in

all of

> the patients studied. The ratio of the cerebrospinal fluid levels to

> serum levels averaged 53.7:1. This ratio is significantly higher than

> the elevations reported for other pathological states for which

> cerebrospinal fluid and serum tumor necrosis factor-alpha levels have

> been simultaneously measured. This observation may offer a unique

> insight into central nervous system inflammatory mechanisms that may

> contribute to the onset of autism and may serve as a potential clinical

> marker. More controlled study of this potentially important observation

> may prove valuable.

>

> PMID: 17560496

>

>

>

>

[Guest guest]

,

I know for a fact that Enbrel has been used for autistic children.

You might try contacting Maura Fisk of the Jonty Foundation about this. (Maura

Fisk

Jonty Foundation Trustee

Email: JontyFoundation@...)

Maura is the mother of an autistic child and was the volunteer coordinator for

Hyrumi

Jyonouchi, M.D.s study on inflammatory cytokines in autism while she was at U

Mn.

Back in 2000, I met Maura when my son was in Dr. Jyonouchi's study. Dr. J

recommended

Enbrel for my son (though I didn't use it) and I know that Maura's son was on it

for some

time. I'm sure Maura could point you to relevant information.

Hirzel

>

> Has anyone tried enbrel in a child with autism? If so, I haven't been

> able to find any articles/references.

>

> Thanks

>

roinflammation.com/content/5/1/2>*

> > Rapid cognitive improvement in Alzheimer's disease following perispinal

> > etanercept administration*

> >

> > L. Tobinick, Hyman Gross

> > Journal of Neuroinflammation 2008, 5:2doi:10.1186/1742-2094-5-2

> >

> > [Provisional PDF

> > <http://www.jneuroinflammation.com/content/pdf/1742-2094-5-2.pdf>]

> >

> >

> > Abstract (provisional)

> >

> > Substantial basic science and clinical evidence suggests that excess

> > tumor necrosis factor-alpha (TNF-alpha) is centrally involved in the

> > pathogenesis of Alzheimer's disease. In addition to its

> pro-inflammatory

> > functions, TNF-alpha has recently been recognized to be a

> > gliotransmitter that regulates synaptic function in neural networks.

> > TNF-alpha has also recently been shown to mediate the disruption in

> > synaptic memory mechanisms, which is caused by beta-amyloid and

> > beta-amyloid oligomers. The efficacy of etanercept, a biologic

> > antagonist of TNF-alpha, delivered by perispinal administration, for

> > treatment of Alzheimer's disease over a period of six months has been

> > previously reported in a pilot study. This report details rapid

> > cognitive improvement, beginning within minutes, using this same

> > anti-TNF treatment modality, in a patient with late-onset Alzheimer's

> > disease. Rapid cognitive improvement following perispinal etanercept

> may

> > be related to amelioration of the effects of excess TNF-alpha on

> > synaptic mechanisms in Alzheimer's disease and provides a promising

> area

> > for additional investigation and therapeutic intervention.

> >

> > * * * *

> >

> > *1: Pediatr Neurol. *2007 Jun;36(6):361-5.

> >

> >

> > *Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of

> > autistic children.*

> >

> > Chez MG, Dowling T, Patel PB, Khanna P, Kominsky M.

> >

> > Department of Neurology, lind lin University, and the Chicago

> > Medical School, North Chicago, IL, USA. chezm2@

> >

> > Recent reports implicating elevated cytokines in the central nervous

> > system in a small number of patients studied with autism have reported

> > clinical regression. These studies have not focused on tumor necrosis

> > factor-alpha as a possible marker for inflammatory damage. A series of

> > 10 children with autism had clinical evaluation of their serum and

> > spinal fluid for inflammatory changes and possible metabolic disease as

> > part of their neurological evaluation. Elevation of cerebrospinal fluid

> > levels of tumor necrosis factor-alpha was significantly higher (mean =

> > 104.10 pg/mL) than concurrent serum levels (mean = 2.78 pg/mL) in

> all of

> > the patients studied. The ratio of the cerebrospinal fluid levels to

> > serum levels averaged 53.7:1. This ratio is significantly higher than

> > the elevations reported for other pathological states for which

> > cerebrospinal fluid and serum tumor necrosis factor-alpha levels have

> > been simultaneously measured. This observation may offer a unique

> > insight into central nervous system inflammatory mechanisms that may

> > contribute to the onset of autism and may serve as a potential clinical

> > marker. More controlled study of this potentially important observation

> > may prove valuable.

> >

> > PMID: 17560496

> >

> >

> >

> >