Re: Ginger extract inhibits LPS induced macrophage activation and function - IL-

[Guest guest]

, Thank you very much for the article. I have been using ginger

roots mainly to boost the GSH production. A dumb question: is ginger

extract the same thing as ginger root? Thank you, Bo

>

> Ginger extract inhibits LPS induced macrophage activation and function

>

> Sudipta Tripathi email, Bruch email and Dilip S Kittur email

>

> BMC Complementary and Alternative Medicine 2008,

> 8:1doi:10.1186/1472-6882-8-1

> Published: 3 January 2008

> http://www.biomedcentral.com/1472-6882/8/1/abstract

> PDF <http://www.biomedcentral.com/content/pdf/1472-6882-8-1.pdf>

> 208k

>

> Background

>

> Macrophages play a dual role in host defence. They act as the first

line

> of defence by mounting an inflammatory response to antigen exposure and

> also act as antigen presenting cells and initiate the adaptive immune

> response. They are also the primary infiltrating cells at the site of

> inflammation. Inhibition of macrophage activation is one of the

possible

> approaches towards modulating inflammation. Both conventional and

> alternative approaches are being studied in this regard. Ginger, an

> herbal product with broad anti inflammatory actions, is used as an

> alternative medicine in a number of inflammatory conditions like

> rheumatic disorders. In the present study we examined the effect of

> ginger extract on macrophage activation in the presence of LPS

stimulation.

> Methods

>

> Murine peritoneal macrophages were stimulated by LPS in presence or

> absence of ginger extract and production of proinflammatory cytokines

> and chemokines were observed. We also studied the effect of ginger

> extract on the LPS induced expression of MHC II, B7.1, B7.2 and CD40

> molecules. We also studied the antigen presenting function of ginger

> extract treated macrophages by primary mixed lymphocyte reaction.

> Results

>

> We observed that ginger extract inhibited IL-12, TNF-alpha, IL-1 (pro

> inflammatory cytokines) and RANTES, MCP-1 (pro inflammatory chemokines)

> production in LPS stimulated macrophages. Ginger extract also down

> regulated the expression of B7.1, B7.2 and MHC class II molecules. In

> addition ginger extract negatively affected the antigen presenting

> function of macrophages and we observed a significant reduction in T

> cell proliferation in response to allostimulation, when ginger extract

> treated macrophages were used as APCs. A significant decrease in

> IFN-gamma and IL-2 production by T cells in response to allostimulation

> was also observed.

> Conclusions

>

> In conclusion ginger extract inhibits macrophage activation and APC

> function and indirectly inhibits T cell activation.

>

>

>