Brain dysfunction in multiple chemical sensitivity.

[Guest guest]

thanks so much for posting this article. The NTEF has always stated that this

was neurological in nature and that was the way to go to get issues resolved in

court, work etc. Even though there are so many other organ systems in the body

affected, this will make it easier to get us away formt he 'psych' dx. Also,

this should stop those who are determined to get the term MCS recognized.

We should now be able to get more recognition as it is physical. Problem as I

see it, big pharm will start working on the 'miracle' drug for this!

http://www.ncbi.nlm.nih.gov/sites/entrez

J Neurol Sci. 2009 Oct 2. [Epub ahead of print]

Brain dysfunction in multiple chemical sensitivity.

Orriols R, Costa R, Cuberas G, Jacas C, Castell J, Sunyer J.

Servei de Pneumologia, Hospital Universitari Vall d' Hebron, Barcelona,

Catalonia, Spain; CIBER Enfermedades Respiratorias (CIBERES), Spain.

Multiple Chemical Sensitivity (MCS) is a chronic acquired disorder of unknown

pathogenesis. The aim of this study was to ascertain whether MCS patients

present brain single photon emission computed tomography (SPECT) and

psychometric scale changes after a chemical challenge. This procedure was

performed with chemical products at non-toxic concentrations in 8 patients

diagnosed with MCS and in their healthy controls. In comparison to controls,

cases presented basal brain SPECT hypoperfusion in small cortical areas of the

right parietal and both temporal and fronto-orbital lobes. After chemical

challenge, cases showed hypoperfusion in the olfactory, right and left

hippocampus, right parahippocampus, right amygdala, right thalamus, right and

left Rolandic and right temporal cortex regions(p</=0.01). By contrast, controls

showed hyperperfusion in the cingulus, right parahippocampus, left thalamus and

some cortex regions (p</=0.01). The clustered deactivation pattern in cases was

stronger than in controls (p=0.012) and the clustered activation pattern in

controls was higher than in cases (p=0.012). In comparison to controls, cases

presented poorer quality of life and neurocognitive function at baseline, and

neurocognitive worsening after chemical exposure. Chemical exposure caused

neurocognitive impairment, and SPECT brain dysfunction particularly in

odor-processing areas, thereby suggesting a neurogenic origin of MCS.

PMID: 19801154 [PubMed - as supplied by publisher]