Re: New Thimerosal Study - Just surfaced in trial

[Guest guest]

Govt. attorney was objecting, big time, to the use of this

information in the trial. Dr. Deth was referencing the study to

support his opinion of the Dr. Hornig mouse paper.

>

>

> Objectives: To determine if thimerosal administration in amounts

> equivalent to vaccines content produces neurotoxic effects on the

> encephalon in postnatal hamsters and on experimentation animals'

> development. Design: Experimental, prospective, bietapic study.

Setting:

> San Faculty of Medicine, Universidad Nacional Mayor de San

> Marcos. Biologic material: Seven-day old hamsters. Material: We

divided

> 45 postnatal hamsters in three groups: group A (n = 15), group B (n

=

> 15) and group C (n = 15). We administered three intramuscular

equivalent

> doses of sucrose and thimerosal in 20 µL of physiological serum

> respectively to groups B and C on birth-days 7 (0,227 µg), 9 (0,216

> µg) and 11 (0,220 µg). Group A received only 20 µL of saline

> solution. Main outcome measures: Body weight, encephalon weight,

> hamster's stature and encephalon histopathological alterations.

Results:

> Anova and student t tests showed statistical significance in favor

of

> low body weight, low encephalon weight and smaller stature in group

C

> with respect to groups A and B hamsters (p<0,000). ÷2 statistical

> significance in relation to the presence of histopathological

> alterations in group C was also obtained (p<0,000). We observed

greater

> relative risk of encephalic alterations in group C. Conclusions: The

> administration of thimerosal in doses equivalent to vaccines

content was

> associated with low corporal weight, low encephalon weight and

smaller

> stature in postnatal hamsters. Neurotoxic effects were also

produced at

> encephalic level, at hippocampus (regions CA1, CA3, DG), cerebral

cortex

> and cerebellum (Purkinje cells and granuloses cells) with decrease

in

> neuronal density, neuronal necrosis, axonal dismyelinization and

> gliosis. In addition, risk increase in developing any of these

> alterations was high in the animal group receiving thimerosal.

>

> http://www.scielo.org.pe/pdf/afm/v68n3/a03v68n3.pdf

> <http://www.scielo.org.pe/pdf/afm/v68n3/a03v68n3.pdf>

>