100 reasons to change the way we think about genetics

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100 reasons to change the way we think about genetics

Article reviews evidence for epigenetic inheritance in wide range of species

http://www.eurekalert.org/pub_releases/2009-05/uocp-1rt051809.php

For years, genes have been considered the one and only way biological traits

could be passed down through generations of organisms.

Not anymore.

Increasingly, biologists are finding that non-genetic variation acquired during

the life of an organism can sometimes be passed on to offspring—a phenomenon

known as epigenetic inheritance. An article forthcoming in the July issue of The

Quarterly Review of Biology lists over 100 well-documented cases of epigenetic

inheritance between generations of organisms, and suggests that non-DNA

inheritance happens much more often than scientists previously thought.

Biologists have suspected for years that some kind of epigenetic inheritance

occurs at the cellular level. The different kinds of cells in our bodies provide

an example. Skin cells and brain cells have different forms and functions,

despite having exactly the same DNA. There must be mechanisms—other than

DNA—that make sure skin cells stay skin cells when they divide.

Only recently, however, have researchers begun to find molecular evidence of

non-DNA inheritance between organisms as well as between cells. The main

question now is: How often does it happen?

" The analysis of these data shows that epigenetic inheritance is ubiquitous …, "

write Eva Jablonka and Gal Raz, both of Tel-Aviv University in Israel. Their

article outlines inherited epigenetic variation in bacteria, protists, fungi,

plants, and animals.

These findings " represent the tip of a very large iceberg, " the authors say.

For example, Jablonka and Raz cite a study finding that when fruit flies are

exposed to certain chemicals, at least 13 generations of their descendants are

born with bristly outgrowths on their eyes. Another study found that exposing a

pregnant rat to a chemical that alters reproductive hormones leads to

generations of sick offspring. Yet another study shows higher rates of heart

disease and diabetes in the children and grandchildren of people who were

malnourished in adolescence.

In these cases, as well as the rest of the cases Jablonka and Raz cite, the

source of the variation in subsequent generations was not DNA. Rather, the new

traits were carried on through epigenetic means.

There are four known mechanisms for epigenetic inheritance. According to

Jablonka and Raz, the best understood of these is " DNA methylation. " Methyls,

small chemical groups within cells, latch on to certain areas along the DNA

strand. The methyls serve as a kind of switch that renders genes active or

inactive.

By turning genes on and off, methyls can have a profound impact on the form and

function of cells and organisms, without changing the underlying DNA. If the

normal pattern of methyls is altered—by a chemical agent, for example—that new

pattern can be passed to future generations.

The result, as in the case of the pregnant rats, can be dramatic and stick

around for generations, despite the fact that underlying DNA remains unchanged.

LAMARCK REVISITED

New evidence for epigenetic inheritance has profound implications for the study

of evolution, Jablonka and Raz say.

" Incorporating epigenetic inheritance into evolutionary theory extends the scope

of evolutionary thinking and leads to notions of heredity and evolution that

incorporate development, " they write.

This is a vindication of sorts for 18th century naturalist Baptiste

Lamarck. Lamarck, whose writings on evolution predated Darwin's,

believed that evolution was driven in part by the inheritance of acquired

traits. His classic example was the giraffe. Giraffe ancestors, Lamarck

surmised, reached with their necks to munch leaves high in trees. The reaching

caused their necks to become slightly longer—a trait that was passed on to

descendants. Generation after generation inherited slightly longer necks, and

the result is what we see in giraffes today.

With the advent of Mendelian genetics and the later discovery of DNA, Lamarck's

ideas fell out of favor entirely. Research on epigenetics, while yet to uncover

anything as dramatic as Lamarck's giraffes, does suggest that acquired traits

can be heritable, and that Lamarck was not so wrong after all.

Eva Jablonka and Gal Raz, " Transgenerational Epigenetic Inheritance: Prevalence,

Mechanisms, and Implications for the Study of Heredity and Evolution, " The

Quarterly Review of Biology, June 2009.

http://www.journals.uchicago.edu/toc/qrb/current.