T. Schultz Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic disorder

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Autism, Vol. 12, No. 3, 293-307 (2008)

DOI: 10.1177/1362361307089518

© 2008 The National Autistic Society, SAGE Publications

Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and

autistic disorder

http://aut.sagepub.com/cgi/content/abstract/12/3/293

Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination,

and autistic disorde

The results of a parent survey

T. Schultz

University of California San Diego, and San Diego State

University, USA,

.schultz@...,

stevendri@...

Hillary S. Klonoff-Cohen

University of California San Diego, USA

Deborah L. Wingard

University of California San Diego, USA

Natacha A. Akshoomoff

University of California San Diego, USA

Caroline A. Macera

San Diego State University, USA

Ming Ji

San Diego State University, USA

The present study was performed to determine whether

acetaminophen (paracetamol) use after the

measles-mumps-rubella vaccination could be associated with

autistic disorder. This case-control study used the results of

an online parental survey conducted from 16 July 2005 to 30

January 2006, consisting of 83 children with autistic disorder

and 80 control children. Acetaminophen use after

measles-mumps-rubella vaccination was significantly associated

with autistic disorder when considering children 5 years

of age or less (OR 6.11, 95% CI 1.42­26.3), after limiting

cases to children with regression in development (OR 3.97, 95%

CI 1.11­14.3), and when considering only children who had

post-vaccination sequelae (OR 8.23, 95% CI 1.56­43.3),

adjusting for age, gender, mother's ethnicity, and the

presence of illness concurrent with measles-mumps-rubella

vaccination. Ibuprofen use after measles-mumps-rubella

vaccination was not associated with autistic disorder.

This preliminary study found that acetaminophen use

after measles-mumps-rubella vaccination was associated with

autistic disorder.