2006: Are vaccines responsible for the epidemic of anaphylaxis in young children today?

[Guest guest]

http://www.whale.to/vaccines/hoffman.html

Anaphylactic children - canaries in the public health

mine shaft?

Are vaccines responsible for the epidemic of

anaphylaxis in young children today?

by

Rita Hoffman

July 2006 [Word

version]

In the presentation speech as winner of the 1913 Nobel Prize in Medicine

for his work with anaphylaxis, Richet said, " We are

so constituted that we can never receive other proteins into the blood

than those that have been modified by digestive juices. Every time

alien protein penetrates by effraction, the organism suffers and becomes

resistant. This resistance lies in increased sensitivity, a sort of

revolt against the second parenteral injection which would be

fatal. At the first injection, the organism was taken by surprise

and did not resist. At the second injection, the organism mans its

defences and answers by the anaphylactic shock. " In naming

" anaphylaxis " , Richet described, " Phylaxis, a word seldom

used, stands in the Greek for protection. Anaphylaxis will thus

stand for the opposite. Anaphylaxis, from its Greek etymological

source, therefore means that state of an organism in which it is rendered

hypersensitive, instead of being protected. " Richet concluded

his lecture by saying, " Seen in these terms, anaphylaxis is a

universal defense mechanism against the penetration of heterogenous

substances in the blood, whence they can not be eliminated. "

[1]

Vaccine antigens injected subcutaneously or intramuscularly prompt

the immune system to create antibodies in the blood against those

antigens. Has medicine, which has used vaccinations containing

" alien proteins " as its cornerstone to control infectious

diseases, been on the wrong track by injecting heterogenous substances

[originating in an outside source; especially: derived from another

species] [2]

into human beings to " control " disease? What would be the

general state of health today if 200 years ago medicine had taken the

path of discovering the keys to promoting a strong, unadulterated immune

system in conjunction with increased nutrition, vitamin and mineral

supplementation along with better sanitation? Has medicine produced

false protection by injecting alien proteins via vaccination which, as

Richet pointed out in his lecture, can render us hypersensitive instead

of being protected?

This hypersensitive state called anaphylaxis is now epidemic in young

children who live every day of their life under threat of death from

everyday, normally harmless substances. The numbers are

staggering. According to Health Canada's web site, " It is

estimated that 600,000 Canadians (two percent of the population) may be

affected by life-threatening allergies, and the numbers are increasing,

especially among children. "

[3]

In 2005 Ontario passed a law to protect anaphylactic students at school

while The Toronto Star reported an estimated 40,000 children in Ontario

with anaphylaxis.

[4]

The recent deaths of three Canadian teenagers exposed to minute

quantities of allergen have caused a world wide media explosion of

anaphylaxis stories. Everyone is asking - why do we have so many

kids with peanut allergies? Why have schools banned peanut butter

sandwiches? Why are kids dying? Richet knew

that foreign proteins penetrating the body could cause anaphylaxis back

in 1913. Some doctors, allergists and anaphylaxis organizations

blame skin creams containing peanut oil and North America's roasting of

peanuts for the epidemic of anaphylaxis. And perhaps weary of

saying that increased consumption of peanuts is the cause of the increase

in peanut allergy some are mentioning the " hygiene hypothesis "

as a cause. A few are even mentioning the " v " word.

Dr. Bruce was quoted in a February 21, 2006 Newsday article

regarding the hygiene hypothesis. " The theory is that because U.S.

children 'use antibacterial soap, get antibiotics at the first sign of a

runny nose and are vaccinated for every potential thing out there,' their

immune systems do not spend time producing anti-infectious responses to

all the diseases they will never get. Instead, their immune systems

may be 'shunting their responses to produce things [anti-infectious

responses] which are more allergic in nature.' "

In a May 18, 2005 CNN article, in an attempt to explain the peanut

allergy epidemic, Dr. Woods of s Hopkins University stated,

" The more your immune system is kept busy by exposure to germs and

infections early in life, the less time it can devote to things like

allergy. " Anne Munoz-Furlong, CEO and founder of U.S. based

The Food Allergy & Anaphylaxis Network (FAAN) in the same article

says " Perhaps our homes are too clean - we've done too much to take

away the job of the immune system. We don't have parasites, a lot

of the childhood diseases you vaccinate and don't have, so maybe for some

people, the immune system is looking for something to do and decides,

'Aha, I don't like milk' or 'I don't like peanuts,' and the body then

attacks the food protein as if it were an enemy invader. "

Somehow I think our God given immune systems are smarter than that - that

is, if left to do the job without any interference!

Anaphylaxis is not the only allergic disease on the rise. On March

31, 2006 Reuters reported that " Allergies such as hay fever are

reaching epidemic proportions in Europe and a failure to treat them

properly is creating a mounting bill for society and the healthcare

system...Around one third of the European population has some kind of

allergy, while one in two children in Britain will have allergies by

2015, costing millions of euros in medical bills, lost work days and even

impaired concentration in school pupils. " The article goes on

to describe, " Allergies were most prevalent in Britain and Ireland,

as well as other English speaking countries like Canada, Australia and

the United States, Burney said, adding they were also becoming more

widespread in new European Union member states. " On May

5, 2005 The Toronto Star devoted an entire section to allergies and

asthma. An article about eczema states, " In Canada, this

incurable skin condition that causes dryness, crusting and thickening

afflicts between 2 million and 5 million people. Experts report its

incidence has tripled since 1970. "

In 2002, prominent Canadian allergist Dr. Vadas went as far to say,

in a television show on severe allergies, " There are factors to do

with how we vaccinate our kids very early on in life, how much drugs,

antibiotics we give the kids early on in life all of which tend to

predispose more towards allergy. " But when asked, " Do you think

early vaccination is not a good thing? " he replied, " No, I

think it's a wonderful thing. It's an absolutely crucial thing from

the standpoint of public health to minimize the likelihood of severe

infections, but on the other hand one of the spin offs is that there are

a certain proportion of the population that are going to be more prone to

developing allergies as a consequence of that.”

[5]

In a February 20, 2006 Globe and Mail article entitled " Is clean

living making us sick? Hygiene hypothesis on food allergies " , Dr.

Vadas followed a " party line " , eliminating the " v "

word. The " party line " to explain this, he said

" holds that consumption of peanuts and the peanut protein has

increased in Western societies. As a result, the more exposure to

peanuts, the more people will be found to be allergic to

them. " It sounds like a " party line " to protect the

vaccine status quo. This does nothing to explain the explosion of

other unusual anaphylactic allergies in children to foods like kiwi,

sesame, soybean and tree nuts. Parents should be receiving

information regarding all of the potential risks and benefits of vaccines

to make an informed decision about vaccinating their children. I

was never told that one of the potential " spin offs " of my

child being vaccinated would be that he would live every day of his life

under threat of death!

If increased consumption of peanut is the cause of peanut anaphylaxis,

then why don't the Chinese and Indonesians, who consume large quantities

of peanut, have the peanut anaphylaxis problems of the western

industrialized nations?

[6]

[7] China

and Indonesia do not routinely vaccinate for Hib (Haemophilus influenza

type , [8][9][10][11] Sweden is a country where 99% of the target

population was vaccinated for Hib in 2001.

[12]

Sweden also has low peanut consumption, yet this low consumption has not

prevented peanut allergy in that country. Van Odijk et al concluded

that " the reaction pattern to peanuts in Sweden is similar to that

in many other countries despite a reported steady and low

consumption. "

[13

] It appears that countries that introduced Hib vaccination

in their infant schedules have high rates of peanut allergy regardless of

consumption.

Children can react to peanut allergens on their first exposure.

[14]

Sensitization to peanut can occur during breastfeeding.

[15] Yet

sensitization through breast milk cannot possibly explain the increase in

peanut anaphylaxis as mothers worldwide have been eating peanuts while

breastfeeding for decades. Zimmerman et al (1989) found in

their study that " these results suggest that highly atopic infants

are at special risk for sensitization to peanut, even when they have

never received peanut..... "

[16

] K.L. Capozza, Health Scout News, in an article entitled

" Study Acquits Peanuts in Allergic Reaction " described a recent

study by Turncanu et al who took three types of children, those with

peanut allergies, those that " outgrew " their allergy and those

who have no peanut allergy. Capozza describes how " after

magnifying these immune cells, or T-cells, the researchers observed that

the T-cells of allergic patients became excited after exposure to

peanut. Once the T-cells react to the peanut extract, a cascade of

allergic responses ensue, from a skin rash to labored

breathing. " He describes how " the research shows,

the condition stems from a person's abnormal immune response. "

[17

][18]

What has happened to peanut allergic children to cause their T-cells, as

Capozza described to become 'excited' to the extent that with some

children just being in the same room with peanuts can cause a

reaction? Could vaccines be the cause?

Dr. Philip Incao aptly describes how vaccines affect the immune response

in his article " How Vaccines Work. " " So the trick of

a vaccination is to stimulate the immune system just enough so that it

makes antibodies and 'remembers' the disease antigen but not so much that

it provokes an acute inflammatory response by the cellular immune system

and makes us sick with the disease we’re trying to prevent! Thus a

vaccination works by stimulating very much the antibody production (Th2)

and by stimulating very little or not at all the digesting and

discharging function of the cellular immune system (Th1). Vaccine

antigens are designed to be 'unprovocative' or 'indigestible' for the

cellular immune system (Th1) and highly stimulating for the

antibody-mediated humoral immune system (Th2). Perhaps it is not

difficult to see then why the repeated use of vaccinations would tend to

shift the functional balance of the immune system toward the

antibody-producing side (Th2) and away from the acute inflammatory

discharging side (the cell-mediated side or Th1). "

[19]

Atopic disorders are the cluster of 3 related disorders, allergies,

asthma, and eczema with anaphylaxis being the most severe form of

allergic reaction. Atopic disorders are pervasive and raise the alert

that the immune system has been sensitized and has shifted away from its

normal functioning TH1 mode into a chronically reactive TH2 mode.

Anaphylaxis to foods in young children seemed to be rare prior to the

introduction of the first Hib polysaccharide vaccine in 1987 (Canada) to

a schedule already containing vaccines for diphtheria, pertussis, tetanus

and polio, measles, mumps and rubella. Beginning in 1992,

many infants were given various Hib vaccines concurrently with DPT-P, and

beginning in 1994 in a combined 5 in 1 vaccine called Penta. In

1997 the acellular pertussis 5 in 1 vaccine Pentacel was

introduced. The cover story in the September 2000 issue of

Professionally Speaking, the magazine of the Ontario College of Teachers

was " An Abnormal Response to Normal Things. " The article begins

with " Teachers have to be aware that allergies can kill. A growing

number of children are at risk - and a well prepared teacher can make all

the difference. " The article explains that " About a decade ago,

the sudden surge in highly allergic children entering school systems

across the province caught many educators off guard. "

Doesn't this " surge " correspond to the introduction of the Hib

vaccine?

In Ontario, the Hepatitis B vaccination series is given in Grade 7, not

at birth, so the Hepatitis B vaccine would not have an impact on the

numbers of young children with peanut and nut anaphylaxis, yet it remains

to be seen if this vaccine may be implicated in increased numbers of

teenagers becoming anaphylactic.

Children in Ontario aged 18 and younger could have received up to five

different types of Hib vaccines. The first Hib vaccine,

introduced in 1987, was a one dose polysaccharide Hib vaccine for

children age 2 and up. Infant immune systems did not mount an

immune response to the polysaccharide vaccine, so vaccine researchers

developed conjugate vaccines to " trick " the infant immune

system into recognizing the Hib antibody.

Conjugate vaccines, according to a U.S. National Institute of Health

website, link " a 'weak' polysaccharide to a protein easily

recognized by the immature immune

system. " [

20] The Hib conjugate vaccines results in " greatly enhanced

antibody responses and establishment of immunological memory " , and

the four conjugate Hib vaccines given to children " differ in a

number of ways, including the protein carrier, polysaccharide size and

types of diluent and preservative.

[21] Who’s to

say that this 'protein easily recognized by the immature immune system'

won't " trick " the infants body into thinking that food eaten at

the same time as the vaccine is an invader worthy of a 'greatly enhanced

antibody response'?

Although Hib vaccines have been credited as being a public health

miracle, the road to the development and implementation of these vaccines

seems to have been anything but smooth. The lack of knowledge about

this vaccine's interactions with the immune system is frightening.

Here are just a few examples:

One of the most shocking studies I came across was Nicol et al concluding

in 2002, a decade after infants were given this vaccine, that 1/10th of

the dose of Haemophilus influenzae type B conjugate vaccine (PRP-T) was

as immunogenic and safe as the full

dose.[22

] Considering that the Hib vaccine results in " greatly

enhanced antibody responses " , does this mean that children have been

receiving 10 times the amount of Hib vaccine that would be necessary to

provide that antibody response, thus creating a hypersensitivity to

proteins encountered during and after vaccination in children, especially

children with a tendency toward allergy?

Also shocking was Pichichero (2000) in his paper on new combination

vaccines, describes.... " the protective threshold for conjugated PRP

[Hib] vaccines is not known..... "

[23]

Pabst and Spady (1990) studied infants immunized at 2, 4, and 6 months

with conjugate Haemophilus influenzae type B vaccine. They found

that " antibody levels were significantly higher in the breast-fed

(57 infants) than in the formula-fed group (24 infants) at 7 months and

at 12 months " and that breastfeeding " enhances the active

immune response in the first year of life, and therefore the feeding

method must be taken into account in the evaluation of vaccine studies in

infants. "

[24]

Many anaphylactic children were breastfed as infants, which would have

boosted this immune response even more! Breast fed and bottle fed

babies receive the same doses of vaccines, even though sixteen years ago

the above authors found that feeding methods should be evaluated in

vaccine studies! This study was later challenged in Scheifele et

al's letter to The Lancet in 1992 in which they conclude that " It

seems that the earlier conclusions were incorrect and that breastfeeding

does not enhance responses to haemophilus b conjugate vaccines, at least

when assessed on completion of the primary series.”

[25].

The Hib vaccine that Pabst and Spady studied was the CRM 197 mutant

diphtheria toxin conjugate vaccine. Scheifele's study used the

PRP-T (tetanus conjugate) vaccine. If Dr. Scheifele was going to

discount Pabst and Spady's results why didn't he use the same vaccine?

Oh, well, full speed ahead! One shot must fit all, breastfed or

not! We must maintain the status quo!

Numerous studies have sounded warnings regarding combination or

concurrently administered vaccines including Hib. Here are just

three examples:

Even as late as May 2000, Rennels et al concluded that " In this

trial concurrent IPV [inactivated polio vaccine] appeared to interfere

with the anti-PRP [Hib] response to DTaP/Hib vaccine suggesting that

introduction of new vaccines may require evaluation of immune

responses to all concurrently administered

vaccines. " [

26]

The 2004 American Academy of Pediatrics Annual Meeting report on New

Combination Vaccines for Childhood Diseases raised red flags about

combination vaccines, saying " However, the reactogenicity and

potential side effects of the combined antigens have not yet been

determined. Since there is the potential for physical and chemical

interaction among the vaccine components and the buffers and

preservatives, the immunogenicity of each component needs to be addressed

to determine whether these are similar to and as effective as the

components given

individually. " [

27]

Redhead K et al (1994) in a very frightening study, state: " However,

combination with the Hib vaccine comprising polysaccharide conjugated to

tetanus toxoid had dramatic effects on tetanus potency and immunogenicity

when assayed in mice. This combination resulted in a five-fold

potentiation of the tetanus potency and a similarly large increase in the

antibody responses to tetanus toxin and toxoid. The level of the

antibody response to the Hib polysaccharide in this vaccine was also

elevated, more than 20-fold, as a result of the

combination. " [

28]

Shouldn't these studies be raising red flags? Antibody responses to

Hib elevated more than 20 fold? Reactogenicity and potential side effects

of combined antigens not yet determined? I haven't seen any studies

that look at the IgE (allergy) levels post vaccination. Surely it's not

much of a stretch to think that infant’s immune systems might be

hypersensitive after receiving these vaccines!

Now let's look at what vaccines could be cross reacting with

peanut. When researchers study allergies and cross reactive

proteins they determine the various molecular weights of the

allergen. Foods with the same molecular weight can cause cross

reactions in allergic persons. And it's not just foods cross

reacting. In a January 22, 2002 news release, the American Academy

of Allergy, Asthma and Immunology provided a list of the most common

foods that are cross reactive to latex including banana, avocado,

chestnut, kiwi and celery. They describe, " The immune system

recognizes the 'cross-reactive' protein, symptoms manifest and an adverse

reaction occurs. An active immune system may not distinguish the

difference between the similar looking proteins, so an allergy to one

member of the food family may result in the person being allergic to all

the members of the same group. "

I have often wondered why vaccines with latex stoppers have not been

considered as a potential cause of the tremendous rise in latex allergy

among highly vaccinated health care workers. Primeau et al (2001)

found that " Natural rubber vial closures released allergenic latex

proteins into the tested solutions in direct contact during storage in

sufficient quantities to elicit positive intradermal skin reactions in

some individuals with LA. These data support a recommendation to

eliminate natural rubber from closures of pharmaceutical vials. "

[29]

There are many vaccines that have latex stoppers that may be sensitizing

people. Health Canada does not have a list, but the state of

Massachusetts provides information regarding which vaccines contain

latex or thimerosal

[30]

If people with latex allergy can have cross reactions with foods, then

one must ask if vaccine ingredients can cause cross reaction with foods

having the same molecular weight?

Using PubMed I looked for molecular weights of ingredients in infant

vaccines and some of the most common allergenic foods in small

children. Measured in kilodaltons (kDa), the most striking

molecular weight that could cross react is 50 kDa contained in the

following: Hib, Diphtheria, Tetanus, Neisseria Meningitidis,

peanut, almond, soybean and cashew. The molecular weight 43 kDa is

present in both Hib and peanut. 20 kDa is present in both Hib and

peanut. 37 kDa is present in both Hib and Almond. 49 kDa is

present in Hib and Mango.

Molecular weight of proteins in

vaccines

Molecular weights of food proteins triggering reactions

- Haemophilus influenzae type B

(Hib)

- Peanut

50, 49, 43, 37, 20, 16,

kDa

50, 43, 20, 16 kDa

- Diphtheria - 50, 27

kDa

- Almond 50, 37 kDa

(also used as carrier protein in some Hib vaccines)

- Soybean 50,16.5 kDa

- Tetanus - 50 kDa

(also used as carrier protein in some Hib

vaccines)

- Cashew 50 kDa

- Neisseria meningitidis

- 50

kDa

- Mango 49 kDa

(also used as carrier

protein in some Hib

vaccines)

References:

Hib

[31-39]

Diphtheria

[40-41]

Tetanus

[42-45]

Neisseria meningitides

[46]

Peanut

[47-50]

Almond

[51-53]

Soybean

[47]

Cashew

[54]

Mango

[55]

So the first vaccines my child received, DPT-P + Hib contained Diphtheria

(50 kDa), Tetanus (50 kDa), Pertussis, Polio, Mutant Diphtheria carrier

protein in the Hibtitre vaccine (50 kDa) plus Hib (50 kDa).

Is there any wonder, when my son encountered peanut (50 kDa), Almond (50

kda) and Cashew (50 kDa) via breastmilk while his body's immune system

was processing the vaccines, that his body went on extreme high alert for

anything with a 50 kDa molecular weight? Granoff and Munson (1986)

describe when conjugate vaccines are prepared, " new antigenic

determinants are formed.....but their presence raises the possibility

that these neoantigens may elicit antibodies cross-reactive with human

antigens. "

[31]

Cross reactive proteins can be very dangerous for people with

allergies. I know a young girl who had vomited after eating cashews

as a toddler and was never given nuts after that time. Not long

after her school age boosters of DTaP-Polio and MMR she was given a piece

of mango and had to be rushed to the hospital. It was only after

some investigating that the parents realized that mango and cashew can

cross react. This girl's mother happens to love mango, and while

she would not bring the fruit into her home she decided it was safe to

eat some at her workplace for lunch, afterward carefully washing her

hands. Upon arriving home several hours later, the mother kissed

the little girl on the cheek. Swelling and hives ensued, and even

with anti-histamines it was days before the child's reaction

subsided. From a kiss on the cheek! Another child with a nut

allergy had an anaphylactic reaction to a fruit juice containing mango,

again the parents being unaware of the cashew/mango cross reaction.

These bizarre immune responses put children at risk of dying every

day.

Stories like these aren't too surprising once you look at the medical

literature where the link between vaccination and anaphylaxis seems

crystal clear in animal studies dating back as far as 1952. Saul

Malkiel, Betty J. Hargis and Leon S. Kind completed numerous studies

where vaccinated animals became anaphylactic, many funded in part by the

National Institute of Health. Imagine reading, from 1959,

" We have repeatedly observed in experiments on mice that a

consequence of the administration of Hemophilus pertussis phase I

organisms given in conjunction with a protein antigen is the enhancement

of anaphylactic sensitization to the foreign protein

antigen. " [

56] And we have allergists telling us that skin creams cause

anaphylaxis? And I was furious when I read Kind and Roesner (1959),

" It is now well known that mice inoculated with Hemophilus pertussis

vaccine develop enhanced sensitivity to lethal effects of histamine,

serotonin, endotoxin, peptone and anaphylactic shock. The ensuing

data will demonstrate that pertussis-inoculated mice can also be killed

with doses of water soluble extract of pollen rye grass which are not

lethal to uninoculated animals. "

[57]

Kind and s (1964) in the Journal Nature, state " It is now

well known that mice injected with Bordetella pertussis vaccine plus an

antigen will produce more antibodies to that antigen than mice injected

with antigen alone. "

[58

] Couldn’t the same apply to babies?

And how do researchers make anaphylactic animal models? They

vaccinate the animals! Countless studies show anaphylaxis being

induced in animals by using toxins and adjuvants used in human

vaccines. Here is one example from hundreds:

Helm et al in Environmental Health Perspectives article " Nonmurine

Animal Models of Food Allergy " discuss ways to create animal models

of human food allergy.

[59]

Animal models are discussed extensively, including " the use of

adjuvants (natural or artificial--alum, cholera toxin, Bordetella

pertussis, and carrageenan are known IgE-selective adjuvants) " in

those animal models. They go on to describe, " In the atopic

dog model for food allergy (Ermel et al. 1997), newborn pups (day 1) were

subcutaneously injected in the axillas with 1 µg of cow's milk, beef,

ragweed, and wheat extracts in alum. Food antigen was again administered

on days 22, 29, 50, 78, and 85. At ages 3, 7, and 11 weeks, all pups were

vaccinated with attenuated distemper-hepatitis vaccine...Immunized pups

responded with allergen-specific IgE by week 3 and peaked at week 26 of

age...All clinical manifestations are consistent with infant, adolescent,

and adult food allergy in humans. "

It has been shown repeatedly that vaccination can cause sensitization,

including anaphylaxis, to vaccine ingredients. et al (2000)

discuss a 4 month old baby's anaphylactic reaction to the CRM 197 protein

in the Hib vaccine.

[60] As

far back as 1940 Cooke et al noted that " The real object of this

presentation is to acquaint the medical profession with proof of the fact

that sensitivity can be induced as a result of the present procedures of

active immunization to tetanus. " [61] Cooke et al also

mentioned Neill et all (1929) noted hypersensitivity to diphtheria

bacilli. [62]

Patrizi et al (1999) and Osawa et al (1991) noted allergic sensitization

to thimerosal. [63][64] -Munoz et al described allergic

sensitization to tetanus and diphtheria toxoids simultaneously.

[65

] Kumagai et al (2002) found " gelatin-specific

cell-mediated immunity develops in subjects inoculated with gelatin

containing DTaP vaccine " and that the specific cellular immune

responses persisted for more than 3 years.

[66]

Sakaguchi et al (1996) concluded that " We reconfirmed a strong

relationship between systemic immediate-type allergic reactions including

anaphylaxis, to vaccines and the presence of specific IgE to

gelatin. "

[67]

Nakayama et al (1999) found that " DTaP vaccine may have a causal

relationship to the development of this gelatin allergy. "

[68]

So, if the medical literature shows anaphylactic sensitization to vaccine

ingredients, then is it much of a leap to think that protein fragments in

those vaccines could be causing cross reactive sensitization with

antigens with the same antigenic determinant?

A key piece of the hypersensitivity puzzle is the vaccine adjuvant

aluminum according to New Zealand researcher and author

. states that “Aluminium is put into vaccines, because

without it, the body will not react to weak strains of antigens.

Aluminium is highly reactive, and is a Th2 ‘skewer’. This is the

whole reason why aluminum is added to vaccines. And Aluminium will ALWAYS

create IGE, and if this happens in the presence of proteins from vaccines

or food antigens in the body, then there is a high chance of allergy

developing.” She points out the study by Yamanishi et al (2003) who

immunized mice against Kunitz-type soybean trypsin inhibitor (KSTI) and

concluded that...“we demonstrated that, regardless of the inability to

adsorb KSTI, alum exerted its adjuvant activity only when it was

co-injected with the antigen. These results showed that some biochemical

effect, other than adsorptive activity, to enhance the production of the

antigen-specific IgE resides in alum.[69] According to , “this goes

along with evidence I have elsewhere that highlights the observation that

aluminum does not have to be absorbed onto the antigen in order for an

immune response to be stimulated. Another thing is that aluminum produces

mostly IgE antibodies (allergic antibodies).” Numerous

studies have also shown that aluminum is linked to allergic responses.

[70

]

VRAN researcher Fletcher notes the importance of digestion (which

can be affected by antibiotic use) in the development of asthma and

allergies. Vaccinations are routinely given to infants and children

even though they may have been given antibiotics for a recent health

issue, certainly affecting their immune response to the vaccine.

Untersmayr et al (2006) found “for the first time the important

gate-keeping function of gastric digestion, both in the sensitization and

the effector phases of food

allergy.”[71

]

Richet described back in his Nobel Lecture in 1913,

" all proteins, without exception produce anaphylaxis: one had seen

this with all sera, milks, organic extracts whatsoever, all vegetable

extracts, microbial protein toxins, yeast cells, dead microbial

bodies. It would be of more interest now to find a protein which

does not produce anaphylaxis than to find one that does. "

He then chillingly states in his conclusion, " It does not matter

much that the individual becomes more vulnerable in this regard.

There is something more important than the salvation of the person and

that is integral preservation of the race. In other words, to

formulate the hypothesis in somewhat abstract terms but clear ones all

the same: the life of the individual is less important than the stability

of the species. Anaphylaxis, perhaps a sorry matter for the

individual, is necessary to the species, often to the detriment of the

individual. The individual may perish, it does not matter.

The species must at any time keep its organic integrity intact.

Anaphylaxis defends the species against the peril of adulteration. "

[1]

How can Richet have won the Nobel Prize in 1913 for this knowledge yet

the medical community today seems to have no clue why our children are

anaphylactic? Why has medicine, to which parents have entrusted their

precious children, continued to vaccinate for more and more diseases,

knowing that our " organic integrity " could be at stake?

May I suggest that researchers or doctors can't see the forest for the

trees, or there is one huge cover-up?

With hundreds of new vaccines in the pipeline, how much longer can we

continue to inject more and more foreign proteins via vaccination into

human beings without eventually creating a totally defenseless

population? How many more children will become anaphylactic, be

rushed to emergency fighting for their lives or die before something is

done?

--------------------------------------

Updated July 2006 - Acknowledgments: Special thanks to Amy and for

their countless hours in the medical library, ,

Critical Decisions Count,

Sandy Gottstein,

www.vaccinationnews.com and

especially to Edda West,

www.vran.org for believing in

" 's Story " . A big thank you to Suzanne Brezovich,

Ingri Cassel, , Fletcher and Edda West for input and

editing. And to my dear little , you are a brave soul.

May our Creator continue to bless and protect you.

For further information, including medical journal articles showing a

vaccine link to anaphylaxis, please visit VRAN's webpage at

www.vran.org under the heading

" Anaphylaxis " .

Footnotes

[1] Richet, - Nobel Lecture Dec. 11,

1913

http://www.nobel.se/medicine/laureates/1913/richet-lecture.html

(April 3, 2006)

[2] Merriam Webster Medical Dictionary

http://www.nlm.nih.gov/medlineplus/mplusdictionary.html

[3] Health Canada - It's Your Health - Severe Allergic

Reactions.

http://www.hc-sc.gc.ca/iyh-vsv/med/allerg_e.html (April 3, 2006)

[4] M. Carolyn Black, " The potential power of Bill 3

- Measure aims to protect estimated 40,000 Ontario students with a

life-threatening allergy to such things as peanuts or insect

stings " Toronto Star March 30, 2005

[5] Health On The Line - " Severe Allergies " -

Videocassette - Discovery Health 2002

[6] Beyer K. et al, Effects of cooking methods on peanut

allergenicity. J Allergy Clin Immunol 2001 June;107(6):1077-81

[7] Ewan, PW. Prevention of peanut allergy. Lancet. 1998

Jul 4;352(9121):4-5.

[8] World Health Organization. Immunization Profile -

China

http://www.who.int/immunization_monitoring/en/globalsummary/countryprofileresult.cfm?C='chn'

(Feb. 17, 2006)

[9] Levine et al, Haemophilus influenzae Type B and

Streptococcus pneumoniae as Causes of Pneumonia Among Children in

Beijing, China. Emerg Infect Dis 2000 6(2)

[10] World Health Organization. Immunization Profile -

Indonesia

http://www.who.int/immunization_monitoring/en/globalsummary/countryprofileresult.cfm?C='idn'

(Feb. 17, 2006)

[11] World Health Organization. Haemophilus influenzae

type B vaccine -

http://www.who.int/vaccines/en/haeflub.shtml (Feb. 17, 2006)

[12] World Health Organization.

http://www.who.int/immunization_monitoring/en/globalsummary/countryprofileresult.cfm?C='swe'

(April 4, 2006)

[13] van Odijk J. et al, Specific IgE antibodies to

peanut in western Sweden - has the occurrence of peanut allergy increased

without an increase in consumption? Allergy 2001 Jun;56(6):573-7

[14] Ewan, PW, Clinical study of peanut and nut allergy

in 62 consecutive patients: new features and associations. BMJ 1996 Apr

27;312(7038):1074-8.

http://bmj.com/cgi/content/full/312/7038/1074

[15] Vadas, P, et al, Detection of peanut allergens in

breast milk of lactating women. JAMA 2001 Apr 4;285(13):1746-8.

[16] Zimmerman B, et al. Highly atopic children:

formation of IgE antibody to food protein, especially peanut. J

Allergy Clin Immunol 1989 Apr;83(4):764-70 PMID 2708736

[17] Study Acquits Peanuts in Allergic Reaction - Finds

condition stems from abnormal immune response. Accessed April 6,

2006

http://www.healthcentral.com/news/newsfulltext.cfm?id=512529

[18] Turcanu V, et al. Characterization of

lymphocyte responses to peanuts in normal children, peanut-allergic

children, and allergic children who acquired tolerance to peanuts.

J. Clin. Invest. 2003 Apr; 111:1065-72. PMID:

12671056

http://www.jci.org/cgi/content/full/111/7/950

[19] Philip F. Incao, MD. How Vaccinations Work . May 5,

1999

http://www.ei-resource.org/articles/gulfwar-art07.asp (April 1,

2006)

[20] NICHD Researchers Honored by World Health

Organization for Developing Vaccines Against Hemophilus Influenzae

December 10, 1996

http://www.nichd.nih.gov/new/releases/cviawar2.cfm (April 4,

2006)

[21] Health Canada Vaccine Preventable Diseases

http://www.phac-aspc.gc.ca/im/vpd-mev/hib_e.html (April 4, 2006)

[22] Nicol M, et al. Haemophilus influenzae type b

conjugate vaccine diluted tenfold in diphtheria-tetanus-whole cell

pertussis vaccine: a randomized trial. Pediatr Infect Dis J 2002

Feb;21(2):138-41 PMID:

11840081

[23] Pichichero, ME. New Combination Vaccines.

Pediatr Clin North Am 2000 Apr;47(2):497-26 PMID:

10761511

[24] Pabst HF, Spady DW. Effect of breast-feeding

on antibody response to conjugate vaccine. Lancet 1990 Aug

4;336(8710):269-70

[25] Scheifele et al. Breastfeeding and antibody

responses to routine vaccination in infants. Lancet. 1992 Dec

5;340(8832):1406.

[26] Rennels MB et al, Diminution of the

anti-polyribosylribitol phosphate response to a combined

diphtheria-tetanus-acellular pertussis/Haemophils influenzae type b

vaccine by concurrent inactivated poliovirus vaccination. Pediatr Infect

Dis J 2000 May;19(5):417-23

[27] Pediatric Infectious Disease Issues: Smallpox,

Combination Vaccines and Methicillin-resistant Staphylococcus aureus,

American Academy of Pediatrics Annual Meeting 2004.

http://www.medscape.com/viewarticle/466494 (March 27, 2006)

[28] Redhead K et al. Combination of DTP and

Haemophilus influenzae type b conjugate vaccines can affect laboratory

evaluation of potency and immunogenicity. Biologicals 1994

Dec;22(4);339-45 PMID 7779360

[29] Primeau MN, Adkinson NF Jr, Hamilton RG. Natural

rubber pharmaceutical vial closures release latex allergens that produce

skin reactions. J Allergy Clin Immunol 2001 Jun;107(6):958-62 PMID:

11398071

[30] Government of Massachusetts

http://www.mass.gov/dph/cdc/epii/imm/vac_safety/rubberthimerosal.pdf

(April 1, 2006)

[31]Granoff DM, Munson RS Jr. Prospects for prevention

of Haemophilus influenzae type b disease by immunization. J Infect Dis

1986 Mar;153(3):448-61 PMID: 3485160

[32] van Alphen L, et al. Characteristics of major outer

membrane proteins of Haemophilus influenzae. J Bacteriol. 1983

Aug;155(2):878-85. PMID:

6603458

[33] Munson RS Jr, Granoff DM. Purification and partial

characterization of outer membrane proteins P5 and P6 from Haemophilus

influenzae type b. Infect Immun. 1985 Sep;49(3):544-9. PMID:

2411657

[34] Munson RS Jr, et al. Purification and comparison of

outer membrane protein P2 from Haemophilus influenzae type b isolates. J

Clin Invest. 1983 Aug;72(2):677-84. PMID:

6603479

[35] Pichichero ME, et al. Do pili play a role in

pathogenicity of Haemophilus influenzae type B? Lancet. 1982 Oct

30;2(8305):960-2. PMID:

6127463

[36] Hetherington SV, et al. Outer membrane protein

binding sites of complement component 3 during opsonization of

Haemophilus influenzae. Infect Immun. 1993 Dec;61(12):5157-63. PMID:

7693595

[37] Coulton JW, Wan DT. The outer membrane of

haemophilus influenzae type b: cell envelope associations of major

proteins. Can J Microbiol. 1983 Feb;29(2):280-7. PMID:

6406024

[38] Barenkamp SJ, Munson RS Jr, Granoff DM. Subtyping

isolates of Haemophilus influenzae type b by outer-membrane protein

profiles. J Infect Dis. 1981 May;143(5):668-76. PMID:

6972422

[39] Yang Y, WR, Chong P, Loosmore SM, Klein MH.

A 20-kilodalton N-terminal fragment of the D15 protein contains a

protective epitope(s) against Haemophilus influenzae type a and type b.

Infect Immun. 1998 Jul;66(7):3349-54. PMID:

9632604

[40] Iwamoto R, et al. An antibody that inhibits the

binding of diphtheria toxin to cells revealed the association of a 27-kDa

membrane protein with the diphtheria toxin receptor. J Biol Chem. 1991

Oct 25;266(30):20463-9. PMID:

1939101

[41] Battistini A, et al. Inhibition of protein

synthesis by diphtheria toxin induces a peculiar pattern of synthesized

protein species. Exp Cell Res. 1988 May;176(1):174-9. PMID:

3371422

[42] Kegel B, Bonifas U, Silberbach K, Kramer B, Weisser

K. In vitro determination of specific toxicity in tetanus vaccines. Dev

Biol (Basel). 2002;111:27-33. PMID:

12678222

[43] Mayorga C, et al. Immediate allergy to tetanus

toxoid vaccine: determination of immunoglobulin E and immunoglobulin G

antibodies to allergenic proteins. Ann Allergy Asthma Immunol. 2003

Feb;90(2):238-43. PMID:

12602673

[44] M, et al. A mutant pertussis toxin molecule

that lacks ADP-ribosyltransferase activity, PT-9K/129G, is an effective

mucosal adjuvant for intranasally delivered proteins. Infect Immun. 1995

Jun;63(6):2100-8. PMID:

7768587

[45] Mayorga C, et al. Immediate allergy to tetanus

toxoid vaccine: determination of immunoglobulin E and immunoglobulin G

antibodies to allergenic proteins. Ann Allergy Asthma Immunol. 2003

Feb;90(2):238-43. PMID:

12602673

[46] De Gaspari EN. Production and

characterization of new monoclonal antibody against Neisseria

meningitidis: study of the cross-reactivity with different bacterial

genera. Hybridoma 2000 Dec;19(6):445-53 PMID:

11152396

[47] Pons L, et al. The 18 kDa peanut oleosin is a

candidate allergen for IgE-mediated reactions to peanuts. Allergy.

2002;57 Suppl 72:88-93. PMID:

12144563

[48] Kleber-Janke T, et al. Selective cloning of peanut

allergens, including profilin and 2S albumins, by phage display

technology. Int Arch Allergy Immunol. 1999 Aug;119(4):265-74. PMID:

10474031

[49] de Jong EC, et al. Identification and partial

characterization of multiple major allergens in peanut proteins. Clin Exp

Allergy. 1998 Jun;28(6):743-51. PMID:

9677140

[50] SA, et al. The promiscuity of immunoglobulin

E binding to peanut allergens, as determined by Western blotting,

correlates with the severity of clinical symptoms. Clin Exp Allergy. 2005

Jun;35(6):767-73. PMID:

15969668

[51] Pasini G, et al. IgE binding to almond proteins in

two CAP-FEIA-negative patients with allergic symptoms to almond as

compared to three CAP-FEIA-false-positive subjects. Allergy. 2000

Oct;55(10):955-8. PMID:

11030377

[52] Lee SH, et al. A 50 kDa maize gamma-zein has marked

cross-reactivity with the almond major protein. J Agric Food Chem. 2005

Oct 5;53(20):7965-70. PMID:

16190657

[53] Database of Food Allergens in AgMoBiol - Common

Allergenic Foods of Plant Origin -

http://ambl.lsc.pku.edu.cn/yjwy/Allergens2.htm (April 4, 2006)

[54] Wang F, et al. Ana o 1, a cashew (Anacardium

occidental) allergen of the vicilin seed storage protein family. J

Allergy Clin Immunol. 2002 Jul;110(1):160-6. PMID:

12110836

[55] Frylinck L, Dubery IA. Protein kinase activities in

ripening mango, Mangifera indica L., fruit tissue. III. Purification and

characterisation of a calcium-regulated protein kinase. Biochim Biophys

Acta. 1998 Sep 8;1387(1-2):342-54. PMID:

9748649

[56] Malkiel S, Hargis BJ. The use of adjuvants in

sensitization of the mouse. J Allergy. 1959 Sep-Oct;30:387-93.

[57] Kind LS, Roesner L. Enhanced susceptibility of

pertussis inoculated mice to pollen extract. Proc Soc Exp Biol Med. 1959

Apr;100(4):808-10.

[58] Kind LS, s WW. IND LS. Local and systemic

anaphylaxis in the pertussis-inoculated mouse. Nature. 1964 Apr

18;202:309-10.

[59] Helm RM et al. Nonmurine Animal Models of Food

Allergy. Environmental Health Perspectives February 2003 Volume 111,

Number 2,

http://www.ehponline.org/members/2003/5705/5705.html (April 4,

2006)

[60] MR et al,

Anaphylaxis Complicating Routine Childhood Immunization: Hemophilus

Influenza b Conjugated Vaccine. Pediatric Asthma, Allergy &

Immunology Dec 2000,14, No. 4:315-321

[61] Cooke et al, Allergy Induced by Immunization

with Tetanus Toxoid. Journal of the American Medical Association.

1940 May;114(19):1854-58

[62] Neill et al, Studies on Hypersensitiveness to

Diphtheria Bacilli. Journal of Experimental Medicine 1929 Jan,

44:33

[63] Patrizi et al, Sensitization to thimerosal in

atopic children. Contact Dermatitis. 1999 Feb;40(2):94-7

[64] Osawa J et al, A probable role for vaccines

containing thimerosal in thimerosal hypersensitivity. Contact

Dermatitis 1991 Mar;24(3):178-82

[65] -Munoz MF et al. Anaphylactic reaction to

diphtheria-tetanus vaccine in a child: specific IgE/IgG determinations

and cross-reactivity studies. Vaccine 2002 Sep

10;20(27-28):3409-12

[66] Kumagai T et al, Gelatin-specific cellular immune

responses persist for more than 3 years after priming with gelatin

containing DTaP vaccine. Clin Exp Allergy 2002

Oct;32(10):1510-4

[67] Sakaguchi M. et al, Food allergy to gelatin in

children with systemic immediate-type reactions, including anaphylaxis,

to vaccines. J Allergy Clin Immunol. 1996 Dec;98(6 Pt

1):1058-61.

[68] Nakayama T, et al. A clinical analysis of gelatin

allergy and determination of its causal relationship to the previous

administration of gelatin-containing acellular pertussis vaccine combined

with diphtheria and tetanus toxoids. J Allergy Clin Immunol. 1999

Feb;103(2 Pt 1):321-5. PMID:

9949325

[69] Yamanishi, R et al. J Nutr Sci Vitaminol (Tokyo).

2003 Dec;49(6):409-13. PMID: 14974731

[70] Can vaccines cause immune dysfunction resulting in

allergies, asthma and anaphylaxis?

http://www.vran.org/vaccines/anaphylaxis/vaccine-ana.htm

[71] Untersmayr E, Jensen-Jarolim E. The effect of

gastric digestion on food allergy. Curr Opin Allergy Clin Immunol. 2006

Jun;6(3):214-9. PMID: 16670517

Bibliography

Canadian Immunization Guide, Sixth Edition. Ottawa: Canadian Medical

Association, 2002

Diodati, . Immunization History, Ethics, Law and Health.

Windsor: Integral Aspects Incorporated, 1999

Medline Medical Dictionary

http://www.nlm.nih.gov/medlineplus/mplusdictionary.html

Scheibner, Viera, Ph.D. Vaccination 100 Years of Orthodox Research shows

that Vaccine Represent a Medical Assault on the Immune System.

Australia: 1993

Your Child's Best Shot, Ottawa: Canadian Paediatric Society,

1997

--------------------------------------------------------

Sheri Nakken, former R.N., MA, Hahnemannian

Homeopath

Vaccination Information & Choice Network, Nevada City CA & Wales

UK

Vaccines -

http://www.wellwithin1.com/vaccine.htm

Vaccine Dangers & Homeopathy Online/email courses