Re: Question about nitrous oxide

[Guest guest]

,

Read the abstract below. This is the most recent information available.

Gretchen

J Neurol Sci. 2008 May 15;268(1-2):160-2.

Safety of nitrous oxide administration in patients with Charcot-Marie-Tooth

disease.

Isbister GK, Burns J, Prior F, Ouvrier RA.

Clinical Pharmacology, The Children's Hospital at Westmead/Tropical Toxinology

Unit, Menzies School of Health Research, Darwin University, Darwin,

Australia.

Nitrous oxide is routinely administered to children and adults with

Charcot-Marie-Tooth disease (CMT) as an anaesthetic for procedures such as nerve

conduction studies and maintenance for general anaesthesia. However it is listed

as a 'moderate to significant' risk of potential toxicity and worsening

neuropathy in people with CMT by the CMT Association (USA), CMT Association of

Australia, CMT International (Canada) and CMT United Kingdom.

We performed a systematic review focussing on the use of nitrous oxide in

patients with CMT to help clarify its safety. This identified 11 studies

reporting 41 exposures to therapeutically inhaled nitrous oxide as maintenance

for general anaesthesia with no reports of adverse effects or worsening of CMT

neuropathy.

In the absence of a single case in the literature reporting worsening neuropathy

in CMT patients receiving nitrous oxide, this review provides good evidence that

nitrous oxide should be considered a safe agent for use in children and adults

with CMT.

[Guest guest]

Mammadino -

About 20 years ago I had one dental experience with Nitrous Oxide and it was

negative.  This incident was many years before my diagnosis.  After a few

minutes of taking Nitrous Oxide I felt like I could not breathe and I was unable

to move my arms so that I could tell my dentist to stop.  It was very scary and

I never used it again. I was unaware until a few year ago the Nitrous Oxide was

on the list of drugs not to be used by CMTers.

Lynda

 

[Guest guest]

The CMTA List http://www.charcot-marie-tooth.org/med_alert.php has Nitrous Oxide

listed 'only when abused.'

[Guest guest]

Thanks for all the input! I think given the info & how hard it could be

otherwise, the nitrous is the best bet. I do really trust her

dentist so it should all go off well.

Thank you again,

[Guest guest]

I had the same experience, also about 20 years ago. Couldn't open my eyes,

couldn't move, was panicking on the inside, lying quietly on the outside. I

don't know if it has anything to do with CMT, but I hated it and won't do it

again. Holli

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> Mammadino -

>

> About 20 years ago I had one dental experience with Nitrous Oxide and it was

negative.  This incident was many years before my diagnosis.  After a few

minutes of taking Nitrous Oxide I felt like I could not breathe and I was unable

to move my arms so that I could tell my dentist to stop.  It was very scary and

I never used it again. I was unaware until a few year ago the Nitrous Oxide was

on the list of drugs not to be used by CMTers.

>

> Lynda

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