Statins are derived from molds.

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Statins are derived from molds. I have often seen individuals exposed to water

damaged buildings who have elevated cholesterol. Also, the elevation occurs in

individuals with metabolic syndrome from exposure to xenobiotics. The message

is clear, be careful of Statins.

http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2704421 & blobtype=pdf

1: CMAJ. 2009 Jul 7;181(1-2):E11-8.

Association between statin-associated myopathy and skeletal muscle damage.

Mohaupt MG, Karas RH, Babiychuk EB, -Freire V, Monastyrskaya K, Iyer L,

Hoppeler H, Breil F, Draeger A.

Department of Nephrology and Hypertension, Inselspital, University of Bern,

Bern, Switzerland.

BACKGROUND: Many patients taking statins often complain of muscle pain and

weakness. The extent to which muscle pain reflects muscle injury is unknown.

METHODS: We obtained biopsy samples from the vastus lateralis muscle of 83

patients. Of the 44 patients with clinically diagnosed statin-associated

myopathy, 29 were currently taking a statin, and 15 had discontinued statin

therapy before the biopsy (minimal duration of discontinuation 3 weeks). We also

included 19 patients who were taking statins and had no myopathy, and 20

patients who had never taken statins and had no myopathy. We classified the

muscles as injured if 2% or more of the muscle fibres in a biopsy sample showed

damage. Using reverse transcriptase polymerase chain reaction, we evaluated the

expression levels of candidate genes potentially related to myocyte injury.

RESULTS: Muscle injury was observed in 25 (of 44) patients with myopathy and in

1 patient without myopathy. Only 1 patient with structural injury had a

circulating level of creatine phosphokinase that was elevated more than 1950 U/L

(10x the upper limit of normal). Expression of ryanodine receptor 3 was

significantly upregulated in patients with biopsy evidence of structural damage

(1.7, standard error of the mean 0.3). INTERPRETATION: Persistent myopathy in

patients taking statins reflects structural muscle damage. A lack of elevated

levels of circulating creatine phosphokinase does not rule out structural muscle

injury. Upregulation of the expression of ryanodine receptor 3 is suggestive of

an intracellular calcium leak.

Jack D. Thrasher, Ph.D.

Toxicologist/Immunotoxicologist/Fetaltoxicologist

www.drthrasher.org

toxicologist1@...

Off: 916-745-4703

Cell: 575-937-1150

L. Crawley, M.ED., LADC

Trauma Specialist

sandracrawley@...

916-745-4703 - Off

775-309-3994 - Cell

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