Using IV antifungal to treat mycotic demyelinating optic neuritis

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Combination of high-dose intravenous immunoglobulins and itraconozole in

treating chronic mycotic demyelinating optic neuritis.ScientificWorldJournal.

2003 Aug 2;3:640-6.

AW, Anyanwu EC, Vojdani A.

Medical Center for Immune, Environmental and Toxic Disorders, 25010 Oakhurst,

Suite 200, Spring, Texas 77386, USA.

Mycotic

demyelinating optic neuritis is a neurological disorder of the visual

system caused by mycotoxins released by indoor toxic molds. Although

the health effect of indoor toxic mold on the population worldwide is

now one of the " emerging diseases " , its involvement in chronic

demyelinating optic neuritis has not been reported. Most of the

neurological and immunologic abnormalities associated with toxic mold

mycotoxins are very difficult to treat successfully, especially neural

demyelination of the central and peripheral nervous systems. This paper

presents the case of a 42-year-old white female, in whom chronic

demyelinating optic neuritis with persistent visual defects due to

chronic exposure to toxic molds was diagnosed at the age of 34 years.

In spite of all the therapeutic services given to her for over 8 years,

her illness persisted and was difficult to treat. However, we

successfully treated her with a combination of intravenous immune

globulin (IVIG) and itraconozole (Sporanox) when all other treatment

modalities failed. This is probably the first report where persistent

toxic mold-induced neurological and immunologic disorders were

successfully treated with a combination of itraconozole and IVIG.

http://www.ncbi.nlm.nih.gov/pubmed/12920306?ordinalpos=6 & itool=EntrezSystem2.PEn\

trez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum