Re: OT: Investigation by author Matsumoto cited as triggering Ivins Anthrax attack

[Guest guest]

Sadly, Gulf War veterans and US soldiers, are still being used as "guinea pigs" and are being "experimented" upon, adding further insult to injury: http://news.google.ca/news?hl=en & q=chantix%20U.S.%20soldiers%20suicides & um=1 & ie=UTF-8 & sa=N & tab=wn Non-smoking drug endangering soldiers' health Aasa Krakow wrote: Matsomoto is the author of VACCINE A, an excellent book published in 2004 that examined the safey of the experimental anthrax vaccine used in the military, and the use of an adjuvant called squalene."Ivins, a microbiologist who had worked with anthrax since the early 1980s, had become a particular target of the criticism because of his many years of research on possible additives that would strengthen the anthrax vaccine.Matsumoto was investigating allegations that, based on Ivins's experiments, an oil-based substance known as squalene might have been secretly added to the vaccine that was given to soldiers during the first Gulf war - and was perhaps the cause of the condition widely known as Gulf war

syndrome."http://www.iht.com/articles/2008/08/09/america/vaccine.phpAmericasU.S. says conflict over anthrax vaccine motivated suspectBy LiptonPublished: August 9, 2008WASHINGTON: Dozens of members of Congress were demanding an "immediate halt" to the Pentagon's mandatory anthrax vaccination effort. Military personnel, under the threat of court-martial, were refusing to submit to the inoculations. The vaccine's sole manufacturing plant was ordered to shut down. And researchers were turning up evidence possibly linking the vaccine to thousands of illnesses of soldiers during the first Gulf war.It was hardly the kind of thank-you that Bruce Ivins expected for the years of painstaking labor in his laboratory at the U.S. Army Medical Research Institute to refine a vaccine so it could reliably protect millions of active-duty military personnel from an anthrax attack by

Saddam Hussein or some other possible adversary.And all of the criticism, which came to a head in 2000 and early 2001, was clearly starting to get on Ivins's nerves.He was profane in an e-mail sent in August 2001 to a colleague at the army research lab in which he denounced an investigative reporter, Matsumoto, who was pressing the army for answers about the anthrax vaccine, including copies of Ivins's laboratory notebooks."We have got better things to do than shine his shoes and pee on command," Ivins wrote.Today in AmericasThis conflict has now been cited by federal investigators as a key part of the reason they believe that Ivins decided to send out the anthrax-laced letters - as such an attack would in a single stroke eliminate all the skepticism and second-guessing."By launching these attacks, he creates a situation, a scenario, where people all of a sudden realize the need to

have this vaccine," , the United States attorney helping lead the investigation, said at a news conference Wednesday in which he outlined the government's case.Ivins, during this period, was already struggling with psychological problems, as he was on medication and undergoing counseling after being overcome by what he himself described as paranoid, delusional thoughts, another possible explanation prosecutors offered for the attack.But Ivins's former colleagues reject this two-part theory, saying it is just one of many flaws in the evidence presented by the government in what they argue, over all, is an unconvincing case.There was a real threat that the anthrax vaccine Ivins had worked on during this period - known as Anthrax Vaccine Absorbed, or AVA - might be pulled from the market, the former colleagues acknowledged. But he and other researchers had already created an alternative

vaccine - considered safer and more effective - so there was no reason for him to take such a rash act."There was a lot of consternation, a lot of pressure to rescue this thing," said Adamovicz, a colleague of Ivins's at the time. "But if AVA failed, he had his next vaccine candidate. It was well on its way to what looked to be a very bright future."The controversy had erupted in the late 1990s, after the Defense Department initiated a mandatory anthrax vaccination program to inoculate 2.4 million active-duty and reserve troops, starting with soldiers most likely to confront biological attacks in war zones overseas.By 2000, more than 570,000 military personnel had been vaccinated, and hundreds had filed an "adverse event report," citing some kind of a reaction after getting the shots, ranging from fatigue, dizziness and muscle pain, to more serious conditions like thyroid disorders or

rhabdomyolysis, a muscle ailment.Congressional hearings were held, and dozens of members of the House of Representatives signed a letter to the Pentagon calling the mandatory vaccination program "a flawed policy that should be immediately stopped." Protests were also organized."What the government is doing is wrong, and it is time to wake up America from its comfortable stupor and say, 'No more,"' one Pennsylvania woman, Gloria Graham, said during a 2000 protest over the vaccine, which she said had made her son ill.The Food and Drug Administration was challenging a Michigan company, then known as BioPort, which had recently bought the sole anthrax vaccine plant in the United States, claiming serious flaws in the manufacturing process.Ivins, a microbiologist who had worked with anthrax since the early 1980s, had become a particular target of the criticism because of his many years of research on

possible additives that would strengthen the anthrax vaccine.Matsumoto was investigating allegations that, based on Ivins's experiments, an oil-based substance known as squalene might have been secretly added to the vaccine that was given to soldiers during the first Gulf war - and was perhaps the cause of the condition widely known as Gulf war syndrome.The Defense Department, as well as officials at Ivins's lab, defended the vaccine, saying that it was both safe and effective and also necessary to protect the military from a possible attack. They rejected the suggestion that active-duty military had been used for any kind of a secret experiment during the Gulf war.(Page 2 of 2)Ivins and his colleagues were clearly disturbed by all of the second- guessing of their work."It was a big concern for us," said Adamovicz, who then was one of Ivins's fellow researchers. "We wanted obviously

to see this vaccine succeed."Ivins expressed his growing frustration with the problems in multiple e-mails he wrote in 2000 and 2001."I think the **** is about to hit the fan bigtime," he wrote in one July 2000 e-mail to a colleague."The final lot of AVA, lot 22, isn't passing the potency test, and now there's nothing to back it up. Plus the control vaccine isn't working. It's just a fine mess."W. Byrne, another former colleague of Ivins's, said that even though the situation was stressful, he doubted that it would have led Ivins to consider sending out anthrax-laced letters, as the Justice Department has alleged."If he was angry about it, I did not pick up on it at all," Byrne said.

[Guest guest]

By the way, does anyone still have a copy of Shaw's study of the anthrax vaccine saved anywhere? It used to be available on either A-CHAMP or Generation Rescue (can't recall which site), but seems to have disappeared from there. (Copyright issues?) That study was funded by (at least in part, if not wholly) the DoD, and I am surprised that the negative results were actually published in a peer-reviewed journal. Does anybody know any more about this? AasaAasa wrote:

Sadly, Gulf War veterans and US soldiers, are still being used as "guinea pigs" and are being "experimented" upon, adding further insult to injury: http://news.google.ca/news?hl=en & q=chantix%20U.S.%20soldiers%20suicides & um=1 & ie=UTF-8 & sa=N & tab=wn Non-smoking drug endangering soldiers' health Aasa Krakow <rkrakowearthlink (DOT) net> wrote: Matsomoto is the author of VACCINE A, an excellent book published in 2004 that examined the safey of the experimental anthrax vaccine used in the military, and the use of an adjuvant called squalene."Ivins, a microbiologist who had worked with anthrax since the early 1980s, had become a particular target of the criticism because of his many years of research on possible additives that would strengthen the anthrax vaccine.Matsumoto was investigating allegations that, based on Ivins's experiments, an oil-based substance known as squalene might have been secretly added to the vaccine that was given to soldiers during the first Gulf war - and was perhaps the cause of the condition widely known as Gulf war

syndrome."http://www.iht.com/articles/2008/08/09/america/vaccine.phpAmericasU.S. says conflict over anthrax vaccine motivated suspectBy LiptonPublished: August 9, 2008WASHINGTON: Dozens of members of Congress were demanding an "immediate halt" to the Pentagon's mandatory anthrax vaccination effort. Military personnel, under the threat of court-martial, were refusing to submit to the inoculations. The vaccine's sole manufacturing plant was ordered to shut down. And researchers were turning up evidence possibly linking the vaccine to thousands of illnesses of soldiers during the first Gulf war.It was hardly the kind of thank-you that Bruce Ivins expected for the years of painstaking labor in his laboratory at the U.S. Army Medical Research Institute to refine a vaccine so it could reliably protect millions of active-duty military personnel from an

anthrax attack by Saddam Hussein or some other possible adversary.And all of the criticism, which came to a head in 2000 and early 2001, was clearly starting to get on Ivins's nerves.He was profane in an e-mail sent in August 2001 to a colleague at the army research lab in which he denounced an investigative reporter, Matsumoto, who was pressing the army for answers about the anthrax vaccine, including copies of Ivins's laboratory notebooks."We have got better things to do than shine his shoes and pee on command," Ivins wrote.Today in AmericasThis conflict has now been cited by federal investigators as a key part of the reason they believe that Ivins decided to send out the anthrax-laced letters - as such an attack would in a single stroke eliminate all the skepticism and second-guessing."By launching these attacks, he creates a situation, a scenario, where people all of a sudden

realize the need to have this vaccine," , the United States attorney helping lead the investigation, said at a news conference Wednesday in which he outlined the government's case.Ivins, during this period, was already struggling with psychological problems, as he was on medication and undergoing counseling after being overcome by what he himself described as paranoid, delusional thoughts, another possible explanation prosecutors offered for the attack.But Ivins's former colleagues reject this two-part theory, saying it is just one of many flaws in the evidence presented by the government in what they argue, over all, is an unconvincing case.There was a real threat that the anthrax vaccine Ivins had worked on during this period - known as Anthrax Vaccine Absorbed, or AVA - might be pulled from the market, the former colleagues acknowledged. But he and other researchers had already created

an alternative vaccine - considered safer and more effective - so there was no reason for him to take such a rash act."There was a lot of consternation, a lot of pressure to rescue this thing," said Adamovicz, a colleague of Ivins's at the time. "But if AVA failed, he had his next vaccine candidate. It was well on its way to what looked to be a very bright future."The controversy had erupted in the late 1990s, after the Defense Department initiated a mandatory anthrax vaccination program to inoculate 2.4 million active-duty and reserve troops, starting with soldiers most likely to confront biological attacks in war zones overseas.By 2000, more than 570,000 military personnel had been vaccinated, and hundreds had filed an "adverse event report," citing some kind of a reaction after getting the shots, ranging from fatigue, dizziness and muscle pain, to more serious conditions like thyroid

disorders or rhabdomyolysis, a muscle ailment.Congressional hearings were held, and dozens of members of the House of Representatives signed a letter to the Pentagon calling the mandatory vaccination program "a flawed policy that should be immediately stopped." Protests were also organized."What the government is doing is wrong, and it is time to wake up America from its comfortable stupor and say, 'No more,"' one Pennsylvania woman, Gloria Graham, said during a 2000 protest over the vaccine, which she said had made her son ill.The Food and Drug Administration was challenging a Michigan company, then known as BioPort, which had recently bought the sole anthrax vaccine plant in the United States, claiming serious flaws in the manufacturing process.Ivins, a microbiologist who had worked with anthrax since the early 1980s, had become a particular target of the criticism because of his many years

of research on possible additives that would strengthen the anthrax vaccine.Matsumoto was investigating allegations that, based on Ivins's experiments, an oil-based substance known as squalene might have been secretly added to the vaccine that was given to soldiers during the first Gulf war - and was perhaps the cause of the condition widely known as Gulf war syndrome.The Defense Department, as well as officials at Ivins's lab, defended the vaccine, saying that it was both safe and effective and also necessary to protect the military from a possible attack. They rejected the suggestion that active-duty military had been used for any kind of a secret experiment during the Gulf war.(Page 2 of 2)Ivins and his colleagues were clearly disturbed by all of the second- guessing of their work."It was a big concern for us," said Adamovicz, who then was one of Ivins's fellow researchers. "We

wanted obviously to see this vaccine succeed."Ivins expressed his growing frustration with the problems in multiple e-mails he wrote in 2000 and 2001."I think the **** is about to hit the fan bigtime," he wrote in one July 2000 e-mail to a colleague."The final lot of AVA, lot 22, isn't passing the potency test, and now there's nothing to back it up. Plus the control vaccine isn't working. It's just a fine mess."W. Byrne, another former colleague of Ivins's, said that even though the situation was stressful, he doubted that it would have led Ivins to consider sending out anthrax-laced letters, as the Justice Department has alleged."If he was angry about it, I did not pick up on it at all," Byrne said.

[Guest guest]

I have been on and off of CHANTIX for two years , trying to quit smoking. In the beginning it makes you irritable. Allot of the symptoms are the withdrawal of nicotine. These people really should just have a cigarette. Really,Chantix does work with the right circumstances and will power. Because I am around other smokers it is difficult to quit. I am actually very pleased with the results of this drug. I am not taking it now, but plan to get back on that wagon soon. I don't smoke near my children and only smoke in more appropriate places, like with coffee or cocktails outdoors . And of course stressful situations. I actually did quite well until that Dx of ASD...Candyce P.S. Judge me if you will, there are things much worse.

Re: OT: Investigation by author Matsumoto cited as triggering Ivins Anthrax attack

By the way, does anyone still have a copy of Shaw's study of the anthrax vaccine saved anywhere? It used to be available on either A-CHAMP or Generation Rescue (can't recall which site), but seems to have disappeared from there. (Copyright issues?) That study was funded by (at least in part, if not wholly) the DoD, and I am surprised that the negative results were actually published in a peer-reviewed journal. Does anybody know any more about this?

AasaAasa <penas7arrogers> wrote:

Sadly, Gulf War veterans and US soldiers, are still being used as "guinea pigs" and are being "experimented" upon, adding further insult to injury:

http://news.google.ca/news?hl=en & q=chantix%20U.S.%20soldiers%20suicides & um=1 & ie=UTF-8 & sa=N & tab=wn

Non-smoking drug endangering soldiers' health

Aasa

Krakow <rkrakowearthlink (DOT) net> wrote:

Matsomoto is the author of VACCINE A, an excellent book published in 2004 that examined the safey of the experimental anthrax vaccine used in the military, and the use of an adjuvant called squalene."Ivins, a microbiologist who had worked with anthrax since the early 1980s, had become a particular target of the criticism because of his many years of research on possible additives that would strengthen the anthrax vaccine.Matsumoto was investigating allegations that, based on Ivins's experiments, an oil-based substance known as squalene might have been secretly added to the vaccine that was given to soldiers during the first Gulf war - and was perhaps the cause of the condition widely known as Gulf war syndrome."http://www.iht.com/articles/2008/08/09/america/vaccine.phpAmericasU.S. says conflict over anthrax vaccine motivated suspectBy LiptonPublished: August 9, 2008WASHINGTON: Dozens of members of Congress were demanding an "immediate halt" to the Pentagon's mandatory anthrax vaccination effort. Military personnel, under the threat of court-martial, were refusing to submit to the inoculations. The vaccine's sole manufacturing plant was ordered to shut down. And researchers were turning up evidence possibly linking the vaccine to thousands of illnesses of soldiers during the first Gulf war.It was hardly the kind of thank-you that Bruce Ivins expected for the years of painstaking labor in his laboratory at the U.S. Army Medical Research Institute to refine a vaccine so it could reliably protect millions of active-duty military personnel from an anthrax attack by Saddam Hussein or some other possible adversary.And all of the criticism, which came to a head in 2000 and early 2001, was clearly starting to get on Ivins's nerves.He was profane in an e-mail sent in August 2001 to a colleague at the army research lab in which he denounced an investigative reporter, Matsumoto, who was pressing the army for answers about the anthrax vaccine, including copies of Ivins's laboratory notebooks."We have got better things to do than shine his shoes and pee on command," Ivins wrote.Today in AmericasThis conflict has now been cited by federal investigators as a key part of the reason they believe that Ivins decided to send out the anthrax-laced letters - as such an attack would in a single stroke eliminate all the skepticism and second-guessing."By launching these attacks, he creates a situation, a scenario, where people all of a sudden realize the need to have this vaccine," , the United States attorney helping lead the investigation, said at a news conference Wednesday in which he outlined the government's case.Ivins, during this period, was already struggling with psychological problems, as he was on medication and undergoing counseling after being overcome by what he himself described as paranoid, delusional thoughts, another possible explanation prosecutors offered for the attack.But Ivins's former colleagues reject this two-part theory, saying it is just one of many flaws in the evidence presented by the government in what they argue, over all, is an unconvincing case.There was a real threat that the anthrax vaccine Ivins had worked on during this period - known as Anthrax Vaccine Absorbed, or AVA - might be pulled from the market, the former colleagues acknowledged. But he and other researchers had already created an alternative vaccine - considered safer and more effective - so there was no reason for him to take such a rash act."There was a lot of consternation, a lot of pressure to rescue this thing," said Adamovicz, a colleague of Ivins's at the time. "But if AVA failed, he had his next vaccine candidate. It was well on its way to what looked to be a very bright future."The controversy had erupted in the late 1990s, after the Defense Department initiated a mandatory anthrax vaccination program to inoculate 2.4 million active-duty and reserve troops, starting with soldiers most likely to confront biological attacks in war zones overseas.By 2000, more than 570,000 military personnel had been vaccinated, and hundreds had filed an "adverse event report," citing some kind of a reaction after getting the shots, ranging from fatigue, dizziness and muscle pain, to more serious conditions like thyroid disorders or rhabdomyolysis, a muscle ailment.Congressional hearings were held, and dozens of members of the House of Representatives signed a letter to the Pentagon calling the mandatory vaccination program "a flawed policy that should be immediately stopped." Protests were also organized."What the government is doing is wrong, and it is time to wake up America from its comfortable stupor and say, 'No more,"' one Pennsylvania woman, Gloria Graham, said during a 2000 protest over the vaccine, which she said had made her son ill.The Food and Drug Administration was challenging a Michigan company, then known as BioPort, which had recently bought the sole anthrax vaccine plant in the United States, claiming serious flaws in the manufacturing process.Ivins, a microbiologist who had worked with anthrax since the early 1980s, had become a particular target of the criticism because of his many years of research on possible additives that would strengthen the anthrax vaccine.Matsumoto was investigating allegations that, based on Ivins's experiments, an oil-based substance known as squalene might have been secretly added to the vaccine that was given to soldiers during the first Gulf war - and was perhaps the cause of the condition widely known as Gulf war syndrome.The Defense Department, as well as officials at Ivins's lab, defended the vaccine, saying that it was both safe and effective and also necessary to protect the military from a possible attack. They rejected the suggestion that active-duty military had been used for any kind of a secret experiment during the Gulf war.(Page 2 of 2)Ivins and his colleagues were clearly disturbed by all of the second- guessing of their work."It was a big concern for us," said Adamovicz, who then was one of Ivins's fellow researchers. "We wanted obviously to see this vaccine succeed."Ivins expressed his growing frustration with the problems in multiple e-mails he wrote in 2000 and 2001."I think the **** is about to hit the fan bigtime," he wrote in one July 2000 e-mail to a colleague."The final lot of AVA, lot 22, isn't passing the potency test, and now there's nothing to back it up. Plus the control vaccine isn't working. It's just a fine mess."W. Byrne, another former colleague of Ivins's, said that even though the situation was stressful, he doubted that it would have led Ivins to consider sending out anthrax-laced letters, as the Justice Department has alleged."If he was angry about it, I did not pick up on it at all," Byrne said.

[Guest guest]

The case against Dr. Bruce Ivins is circumstantial at best and extremely weak, leaving key elements unanswered. What was the process of elimination by which all other scientists in the lab were cast aside as suspects? The anthrax included in the envelopes was a powder, and Ivins had no access to the equipment that could produce a powder version of anthrax. Some of the envelopes were mailed from locations that would have required a 7 hour drive during the night at a time he was regularly showing up for work. Outside of the fact that Ivins worked at the lab, there is not a solid piece of evidence pointing to his potential guilt. Ah, but what about the therapist who claimed Ivins as a "sciopath" with "homicidal" tendencies? Is she credible? Or would she be a person who could be intimidated or bribed into cooperation with the FBI? What else is in her past, known only to the FBI, that could be used against her if she failed to cooperate? KP Stoller, MDPresident, International Hyperbaric Medical AssocMedical Director, Hyperbaric Medical Center of New Mexicowww.hbotnm.comPlease note: message attached

____________________________________________________________

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Matsomoto is the author of VACCINE A, an excellent book published in 2004 that examined the safey of the experimental anthrax vaccine used in the military, and the use of an adjuvant called squalene."Ivins, a microbiologist who had worked with anthrax since the early 1980s, had become a particular target of the criticism because of his many years of research on possible additives that would strengthen the anthrax vaccine.Matsumoto was investigating allegations that, based on Ivins's experiments, an oil-based substance known as squalene might have been secretly added to the vaccine that was given to soldiers during the first Gulf war - and was perhaps the cause of the condition widely known as Gulf war syndrome."http://www.iht.com/articles/2008/08/09/america/vaccine.phpAmericasU.S. says conflict over anthrax vaccine motivated suspectBy LiptonPublished: August 9, 2008WASHINGTON: Dozens of members of Congress were demanding an "immediate halt" to the Pentagon's mandatory anthrax vaccination effort. Military personnel, under the threat of court-martial, were refusing to submit to the inoculations. The vaccine's sole manufacturing plant was ordered to shut down. And researchers were turning up evidence possibly linking the vaccine to thousands of illnesses of soldiers during the first Gulf war.It was hardly the kind of thank-you that Bruce Ivins expected for the years of painstaking labor in his laboratory at the U.S. Army Medical Research Institute to refine a vaccine so it could reliably protect millions of active-duty military personnel from an anthrax attack by Saddam Hussein or some other possible adversary.And all of the criticism, which came to a head in 2000 and early 2001, was clearly starting to get on Ivins's nerves.He was profane in an e-mail sent in August 2001 to a colleague at the army research lab in which he denounced an investigative reporter, Matsumoto, who was pressing the army for answers about the anthrax vaccine, including copies of Ivins's laboratory notebooks."We have got better things to do than shine his shoes and pee on command," Ivins wrote.Today in AmericasThis conflict has now been cited by federal investigators as a key part of the reason they believe that Ivins decided to send out the anthrax-laced letters - as such an attack would in a single stroke eliminate all the skepticism and second-guessing."By launching these attacks, he creates a situation, a scenario, where people all of a sudden realize the need to have this vaccine," , the United States attorney helping lead the investigation, said at a news conference Wednesday in which he outlined the government's case.Ivins, during this period, was already struggling with psychological problems, as he was on medication and undergoing counseling after being overcome by what he himself described as paranoid, delusional thoughts, another possible explanation prosecutors offered for the attack.But Ivins's former colleagues reject this two-part theory, saying it is just one of many flaws in the evidence presented by the government in what they argue, over all, is an unconvincing case.There was a real threat that the anthrax vaccine Ivins had worked on during this period - known as Anthrax Vaccine Absorbed, or AVA - might be pulled from the market, the former colleagues acknowledged. But he and other researchers had already created an alternative vaccine - considered safer and more effective - so there was no reason for him to take such a rash act."There was a lot of consternation, a lot of pressure to rescue this thing," said Adamovicz, a colleague of Ivins's at the time. "But if AVA failed, he had his next vaccine candidate. It was well on its way to what looked to be a very bright future."The controversy had erupted in the late 1990s, after the Defense Department initiated a mandatory anthrax vaccination program to inoculate 2.4 million active-duty and reserve troops, starting with soldiers most likely to confront biological attacks in war zones overseas.By 2000, more than 570,000 military personnel had been vaccinated, and hundreds had filed an "adverse event report," citing some kind of a reaction after getting the shots, ranging from fatigue, dizziness and muscle pain, to more serious conditions like thyroid disorders or rhabdomyolysis, a muscle ailment.Congressional hearings were held, and dozens of members of the House of Representatives signed a letter to the Pentagon calling the mandatory vaccination program "a flawed policy that should be immediately stopped." Protests were also organized."What the government is doing is wrong, and it is time to wake up America from its comfortable stupor and say, 'No more,"' one Pennsylvania woman, Gloria Graham, said during a 2000 protest over the vaccine, which she said had made her son ill.The Food and Drug Administration was challenging a Michigan company, then known as BioPort, which had recently bought the sole anthrax vaccine plant in the United States, claiming serious flaws in the manufacturing process.Ivins, a microbiologist who had worked with anthrax since the early 1980s, had become a particular target of the criticism because of his many years of research on possible additives that would strengthen the anthrax vaccine.Matsumoto was investigating allegations that, based on Ivins's experiments, an oil-based substance known as squalene might have been secretly added to the vaccine that was given to soldiers during the first Gulf war - and was perhaps the cause of the condition widely known as Gulf war syndrome.The Defense Department, as well as officials at Ivins's lab, defended the vaccine, saying that it was both safe and effective and also necessary to protect the military from a possible attack. They rejected the suggestion that active-duty military had been used for any kind of a secret experiment during the Gulf war.(Page 2 of 2)Ivins and his colleagues were clearly disturbed by all of the second-guessing of their work."It was a big concern for us," said Adamovicz, who then was one of Ivins's fellow researchers. "We wanted obviously to see this vaccine succeed."Ivins expressed his growing frustration with the problems in multiple e-mails he wrote in 2000 and 2001."I think the **** is about to hit the fan bigtime," he wrote in one July 2000 e-mail to a colleague."The final lot of AVA, lot 22, isn't passing the potency test, and now there's nothing to back it up. Plus the control vaccine isn't working. It's just a fine mess."W. Byrne, another former colleague of Ivins's, said that even though the situation was stressful, he doubted that it would have led Ivins to consider sending out anthrax-laced letters, as the Justice Department has alleged."If he was angry about it, I did not pick up on it at all," Byrne said.