allergy,IgE,

[Guest guest]

this first one is from 2000, just a interesting read, things have hopefully

changed sence than.

Determinants of Clinical Allergic Disease

The Relevance of Indoor Allergens to the Increase in Asthma

The main characteristics of an allergen are that they are immunologically

foreign, freely soluble, and are inhaled repeatedly.

http://ajrccm.atsjournals.org/cgi/content/full/162/3/S1/S128

Specific IgE and IgG Responses in Atopic versus Nonatopic Subjects

http://ajrccm.atsjournals.org/cgi/content/full/162/3/S1/S124#SEC2

Relationship between helminthic infection and IgE response in atopic and

nonatopic children in a tropical environment/polyclonal IgE synthesis

However, these infections not only stimulate the production of antiparasite IgE

antibody but can nonspecifically induce polyclonal IgE synthesis that results in

highly elevated total serum IgE levels. Such polyclonal stimulation can diminish

specific IgE antibody responses and cause saturation of mast cell Fc & #8712;

receptors, thus inhibiting allergic reactivity. This may represent a mechanism

of immune evasion by the parasite. Objective: Because an atopic disposition is

generally recognized to be associated with elevated IgE synthesis against

environmental allergens, the aim of this study was to evaluate the influence of

atopy on the antiparasite response.

http://cat.inist.fr/?aModele=afficheN & cpsidt=2174833

parasitic helminth infections/nonspecific,specific IgE

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127741/?tool=pmcentrez

Infection and the IgE response

References and further reading may be available for this article. To view

references and further reading you must purchase this article.

G. and M. Humbert

Service de Pneumologie et Réanimation Respiratoire, Antenne d'Immunopathologie

Respiratoire, Institut Paris-Sud sur les Cytokines, Hôpital Antoine-Béclère,

157, rue de la Porte de Trivaux, 92140 CLAMART, France

Available online 16 May 2005.

Summary

Immunoglobulin E (IgE) production is regulated by several T cell subsets

characterized by specific cytokine production patterns. The cytokine composition

of the microenvironment determines which T helper (Th) subtype will develop from

Th0 cells, and therefore which type of response the B cells will exhibit. A

microenvironment dominated by interleukin-4 (IL-4) and IL-13 promotes the

development of Th2 cells (which produce IL-4, IL-3, IL-5, IL-9, and IL-13) and B

cell class commutation toward IgEs. IgE production in response to infections, in

the absence of hypersensitivity, is seen primarily in parasitic infections. Its

beneficial and/or harmful effects remain controversial. It has been suggested

that an IgE response to viral infections may play a role in the genesis of

allergic-type manifestations, in particular after respiratory syncytial virus

bronchiolitis in children.

http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6W8N-4G635VY-DN & _user=\

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