Re: Effects of acute exposure to aluminum on blood-brain barrier and the protection of zinc

[Guest guest]

---Too bad the children are already zinc depleted by the folate in

the prenatals which of course also contain iron which competes with

zinc. In EOHarm , Aasa wrote:

>

> 1: Neurosci Lett. 2008 Sep 3. [Epub ahead of print] Links

> Effects of acute exposure to aluminum on blood-brain barrier and

the protection of zinc.Song Y, Xue Y, Liu X, Wang P, Liu L.

> Department of Experimental Center of the Functional Subjects,

College of Basic Medicine, China Medical University, Shenyang 110001,

China.

>

> http://www.ncbi.nlm.nih.gov/pubmed/18786610?

>

> Effects of acute exposure to aluminum on blood-brain barrier and

the protection of zinc.

>

> " Our present studies suggest that aluminum increases the

permeability of BBB by changing its ultrastructure and the expression

of occludin and F-actin. Zinc can protect the integrity of BBB in

juvenile rats that are exposed to aluminum and inhibit the decrease

of tight junction protein occludin and F-actin expression in BBB. "

>

>

> Aluminum and zinc are two important trace elements in an organism.

Although several studies have demonstrated their impacts on the

intelligence, very little was known about their effects on the

integrity of blood-brain barrier (BBB). To study the effects of

aluminum and zinc on the permeability of BBB, different doses of

aluminum and appropriate zinc were administered to rats. blue

was detected in brain to determine the permeability of BBB. The

ultrastructure of BBB was observed under the transmission electron

microscope. Immunohistochemistry and Western blot method were used to

detect the expression of skeleton protein F-actin and tight junction

protein occludin in brain capillary endothelium. The data indicated

that compared with the control group, blue in brains increased

(P<0.01), the ultrastructure of BBB changed and the expression of F-

actin and occludin decreased (P<0.01) in the aluminum-toxic group.

Compared with the aluminum-toxic

> groups, the permeability of BBB to blue decreased (P<0.01),

the damage of the BBB ultrastructure was attenuated and the

expression of F-actin and occludin increased (P<0.05) in the aluminum-

zinc group. Our present studies suggest that aluminum increases the

permeability of BBB by changing its ultrastructure and the expression

of occludin and F-actin. Zinc can protect the integrity of BBB in

juvenile rats that are exposed to aluminum and inhibit the decrease

of tight junction protein occludin and F-actin expression in BBB.

>