Vitamin D, innate immunity, and influenza : Compelling epidemiological evidence indicates vitamin D deficiency is the seasonal stimulus

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Vitamin D, innate immunity, and influenza"Hope-Simpson's model theorized that an unidentified "seasonal stimulus," inextricably bound to solar radiation, substantially controlled the seasonality of influenza. Recent evidence suggests the "seasonal stimulus" may be seasonal impairments of the antimicrobial peptide (AMPs) systems crucial to innate immunity [22], impairments caused by dramatic seasonal fluctuations in 25-hydroxy-vitamin D [25(OH)D] levels [23]. (Figure 1) The evidence that vitamin D has profound effects on innate immunity is rapidly growing [24] ...ConclusionKilbourne once wrote the "student of influenza is constantly looking back over his shoulder and asking 'what happened?' in the hope that understanding of past events will alert him to the catastrophes of the future" [89]. That is all we are attempting ...Compelling epidemiological evidence indicates vitamin D deficiency is the "seasonal stimulus" [22]."http://www.virologyj.com/content/5/1/29

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I saw this earlier in the week: http://articles.mercola.com/sites/articles/archive/2008/10/21/avoid-flu-shots-vitamin-d-is-a-better-way.aspx

>> Vitamin D, innate immunity, and influenza> > "Hope-Simpson's model theorized that an unidentified "seasonal > stimulus," inextricably bound to solar radiation, substantially > controlled the seasonality of influenza. Recent evidence suggests the > "seasonal stimulus" may be seasonal impairments of the antimicrobial > peptide (AMPs) systems crucial to innate immunity [22], impairments > caused by dramatic seasonal fluctuations in 25-hydroxy-vitamin D > [25(OH)D] levels [23]. (Figure 1) The evidence that vitamin D has > profound effects on innate immunity is rapidly growing [24] ...> > Conclusion> > Kilbourne once wrote the "student of influenza is constantly looking > back over his shoulder and asking 'what happened?' in the hope that > understanding of past events will alert him to the catastrophes of the > future" [89]. That is all we are attempting ...> > Compelling epidemiological evidence indicates vitamin D deficiency is > the "seasonal stimulus" [22]."> > http://www.virologyj.com/content/5/1/29>